{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:28:19Z","timestamp":1771550899733,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["19H04273"],"award-info":[{"award-number":["19H04273"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005738","name":"Central Research Institute of Fukuoka University","doi-asserted-by":"publisher","award":["197003"],"award-info":[{"award-number":["197003"]}],"id":[{"id":"10.13039\/501100005738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nucleotide excision repair (NER) is a repair mechanism that removes DNA lesions induced by UV radiation, environmental mutagens and carcinogens. There exists sufficient evidence against acetaldehyde suggesting it to cause a variety of DNA lesions and be carcinogenic to humans. Previously, we found that acetaldehyde induces reversible intra-strand GG crosslinks in DNA similar to those induced by cis-diammineplatinum(II) that is subsequently repaired by NER. In this study, we analysed the repairability by NER mechanism and the mutagenesis of acetaldehyde. In an in vitro reaction setup with NER-proficient and NER-deficient xeroderma pigmentosum group A (XPA) cell extracts, NER reactions were observed in the presence of XPA recombinant proteins in acetaldehyde-treated plasmids. Using an in vivo assay with living XPA cells and XPA-correcting XPA cells, the repair reactions were also observed. Additionally, it was observed that DNA polymerase eta inserted dATP opposite guanine in acetaldehyde-treated oligonucleotides, suggesting that acetaldehyde-induced GG-to-TT transversions. These findings show that acetaldehyde induces NER repairable mutagenic DNA lesions.<\/jats:p>","DOI":"10.1093\/carcin\/bgab087","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T11:34:00Z","timestamp":1631878440000},"page":"52-59","source":"Crossref","is-referenced-by-count":9,"title":["Acetaldehyde induces NER repairable mutagenic DNA lesions"],"prefix":"10.1093","volume":"43","author":[{"given":"Yuina","family":"Sonohara","sequence":"first","affiliation":[{"name":"Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reine","family":"Takatsuka","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikahide","family":"Masutani","sequence":"additional","affiliation":[{"name":"Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigenori","family":"Iwai","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-3411","authenticated-orcid":false,"given":"Isao","family":"Kuraoka","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, Japan"},{"name":"Department of Chemistry, Faculty of Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"2022021111033784400_CIT0001","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1126\/science.286.5446.1897","article-title":"Quality control by DNA repair","volume":"286","author":"Lindahl","year":"1999","journal-title":"Science"},{"key":"2022021111033784400_CIT0002","doi-asserted-by":"crossref","first-page":"190166","DOI":"10.1098\/rsob.190166","article-title":"Nucleotide excision repair genes shaping embryonic development","volume":"9","author":"Ara\u00fajo","year":"2019","journal-title":"Open Biol."},{"key":"2022021111033784400_CIT0003","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/carcin\/bgm282","article-title":"Xeroderma pigmentosum genes: functions inside and outside DNA repair","volume":"29","author":"Sugasawa","year":"2008","journal-title":"Carcinogenesis"},{"key":"2022021111033784400_CIT0004","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrc1652","article-title":"Cancer in xeroderma pigmentosum and related disorders of DNA repair","volume":"5","author":"Cleaver","year":"2005","journal-title":"Nat. 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