{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T07:48:29Z","timestamp":1744444109629,"version":"3.37.3"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC-81874278","NSFC-81601839"],"award-info":[{"award-number":["NSFC-81874278","NSFC-81601839"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hubei Natural Science Foundation","award":["2019CFB682"],"award-info":[{"award-number":["2019CFB682"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Substantial evidence highlighted the critical role of long non-coding RNAs (lncRNA) in driving hepatocarcinogenesis. We hypothesized that functional variants in genome-wide association studies (GWASs) associated loci might alter the expression levels of lncRNAs and contribute to the development of hepatocellular carcinoma (HCC). Here, we prioritized potentially cis-expression quantitative trait loci-based single nucleotide polymorphism (SNP)-lncRNA association together with the physical interaction by the analyses from Hi-C data in GWAS loci of chronic hepatitis B and HCC. Subsequently, by leveraging two-stage case-control study (1738 hepatitis B [HBV]) related HCC cases and 1988 HBV persistent carriers) and biological assays, we identified that rs2647046 was significantly associated with HCC risk (odds ratio = 1.26, 95% CI = 1.11 to 1.43, P = 4.14 \u00d7 10\u22124). Luciferase reporter assays and electrophoretic mobility shift assays showed that rs2647046 A allele significantly increased transcriptional activity via influencing transcript factor binding affinity. Allele-specific chromosome conformation capture assays revealed that enhancer with rs2647046 interacted with the HLA-DQB1-AS1 promoter to allele-specifically influence its expression by CTCF-mediated long-range loop. Cell proliferation assays indicated that HLA-DQB1-AS1 is a potential oncogene in HCC. Our study showed HLA-DQB1-AS1 regulated by a causal SNP in a long-range interaction manner conferred the susceptibility to HCC, suggesting an important mechanism of modulating lncRNA expression for risk-associated SNPs in the etiology of HCC.<\/jats:p>","DOI":"10.1093\/carcin\/bgab095","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T10:44:11Z","timestamp":1634640251000},"page":"1347-1356","source":"Crossref","is-referenced-by-count":11,"title":["Hepatocellular carcinoma risk variant modulates lncRNA HLA-DQB1-AS1 expression via a long-range enhancer\u2013promoter interaction"],"prefix":"10.1093","volume":"42","author":[{"given":"Haoxue","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beifang","family":"Yang","sequence":"additional","affiliation":[{"name":"Hubei Institute for Infectious Disease Control and Prevention, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaoyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Virology, Wuhan Centers for Disease Prevention and Control, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingting","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zequn","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caibo","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Miao","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbo","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Wuhan University, Wuhan 430071, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5060-895X","authenticated-orcid":false,"given":"Rong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"2021111800101396600_CIT0001","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin.,"},{"key":"2021111800101396600_CIT0002","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jamaoncol.2017.3055","article-title":"The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the global burden of disease study 2015","volume":"3","author":"Global Burden of Disease Liver Cancer, C.","year":"2017","journal-title":"JAMA Oncol."},{"key":"2021111800101396600_CIT0003","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S1473-3099(15)00218-2","article-title":"Seroepidemiology of hepatitis B virus infection in 2 million men aged 21-49 years in rural China: a population-based, cross-sectional study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet. Infect. Dis.,"},{"key":"2021111800101396600_CIT0004","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jhep.2016.12.010","article-title":"Germline and somatic DICER1 mutations in familial and sporadic liver tumors","volume":"66","author":"Caruso","year":"2017","journal-title":"J. Hepatol."},{"key":"2021111800101396600_CIT0005","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jhep.2012.02.035","article-title":"Single nucleotide polymorphisms and risk of hepatocellular carcinoma in cirrhosis","volume":"57","author":"Nahon","year":"2012","journal-title":"J. Hepatol.,"},{"key":"2021111800101396600_CIT0006","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ng.809","article-title":"Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma","volume":"43","author":"Kumar","year":"2011","journal-title":"Nat. Genet.,"},{"key":"2021111800101396600_CIT0007","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/ng.2809","article-title":"New loci associated with chronic hepatitis B virus infection in Han Chinese","volume":"45","author":"Hu","year":"2013","journal-title":"Nat. Genet.,"},{"key":"2021111800101396600_CIT0008","doi-asserted-by":"crossref","first-page":"R102","DOI":"10.1093\/hmg\/ddv259","article-title":"Non-coding genetic variants in human disease","volume":"24","author":"Zhang","year":"2015","journal-title":"Hum. Mol. Genet.,"},{"key":"2021111800101396600_CIT0009","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrg.2015.17","article-title":"Role of non-coding sequence variants in cancer","volume":"17","author":"Khurana","year":"2016","journal-title":"Nat. Rev. Genet.,"},{"key":"2021111800101396600_CIT0010","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.cell.2011.03.014","article-title":"No-nonsense functions for long noncoding RNAs","volume":"145","author":"Nagano","year":"2011","journal-title":"Cell,"},{"key":"2021111800101396600_CIT0011","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08975","article-title":"Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis","volume":"464","author":"Gupta","year":"2010","journal-title":"Nature,"},{"key":"2021111800101396600_CIT0012","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41588-018-0120-1","article-title":"Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression","volume":"50","author":"Zhang","year":"2018","journal-title":"Nat. Genet.,"},{"key":"2021111800101396600_CIT0013","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nm.3981","article-title":"The emerging role of lncRNAs in cancer","volume":"21","author":"Huarte","year":"2015","journal-title":"Nat. Med.,"},{"key":"2021111800101396600_CIT0014","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13046-015-0136-7","article-title":"Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge","volume":"34","author":"Deng","year":"2015","journal-title":"J. Exp. Clin. Cancer Res.,"},{"key":"2021111800101396600_CIT0015","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1038\/s41467-018-04006-0","article-title":"The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun.,"},{"key":"2021111800101396600_CIT0016","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/hep.29405","article-title":"Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6\/STAT3 signaling pathway","volume":"67","author":"Zhang","year":"2018","journal-title":"Hepatology,"},{"key":"2021111800101396600_CIT0017","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1038\/onc.2014.456","article-title":"Junk DNA and the long non-coding RNA twist in cancer genetics","volume":"34","author":"Ling","year":"2015","journal-title":"Oncogene,"},{"key":"2021111800101396600_CIT0018","doi-asserted-by":"crossref","first-page":"D1001","DOI":"10.1093\/nar\/gkt1229","article-title":"The NHGRI GWAS Catalog, a curated resource of SNP-trait associations","volume":"42","author":"Welter","year":"2014","journal-title":"Nucleic Acids Res.,"},{"key":"2021111800101396600_CIT0019","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"Ward","year":"2012","journal-title":"Nucleic Acids Res.,"},{"key":"2021111800101396600_CIT0020","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1093\/nar\/gkv295","article-title":"An update on LNCipedia: a database for annotated human lncRNA sequences","volume":"43","author":"Volders","year":"2015","journal-title":"Nucleic Acids Res.,"},{"key":"2021111800101396600_CIT0021","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nature05874","article-title":"Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project","volume":"447","author":"Consortium, E.P.","year":"2007","journal-title":"Nature"},{"key":"2021111800101396600_CIT0022","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1038\/s41388-019-1117-7","article-title":"LINC01149 variant modulates MICA expression that facilitates hepatitis B virus spontaneous recovery but increases hepatocellular carcinoma risk","volume":"39","author":"Zhong","year":"2020","journal-title":"Oncogene,"},{"key":"2021111800101396600_CIT0023","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc.,"},{"key":"2021111800101396600_CIT0024","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/hep.29531","article-title":"Human leukocyte antigen variants and risk of hepatocellular carcinoma modified by hepatitis C virus genotypes: a genome-wide association study","volume":"67","author":"Lee","year":"2018","journal-title":"Hepatology,"},{"key":"2021111800101396600_CIT0025","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1158\/1078-0432.CCR-17-2537","article-title":"Genome-wide association study identifies a new locus at 7q21.13 associated with hepatitis B virus-related hepatocellular carcinoma","volume":"24","author":"Li","year":"2018","journal-title":"Clin. Cancer Res.,"},{"key":"2021111800101396600_CIT0026","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1038\/s41598-018-26217-7","article-title":"Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma","volume":"8","author":"Sawai","year":"2018","journal-title":"Sci. Rep.,"},{"key":"2021111800101396600_CIT0027","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1053\/j.gastro.2017.01.041","article-title":"Genome-wide association study identifies TLL1 variant associated with development of hepatocellular carcinoma after eradication of hepatitis C virus infection","volume":"152","author":"Matsuura","year":"2017","journal-title":"Gastroenterology,"},{"key":"2021111800101396600_CIT0028","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg.2015.10","article-title":"Unique features of long non-coding RNA biogenesis and function","volume":"17","author":"Quinn","year":"2016","journal-title":"Nat. Rev. Genet.,"},{"key":"2021111800101396600_CIT0029","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrg.2015.17","article-title":"Role of non-coding sequence variants in cancer","volume":"17","author":"Khurana","year":"2016","journal-title":"Nat. Rev. Genet.,"},{"key":"2021111800101396600_CIT0030","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nature08872","article-title":"Understanding mechanisms underlying human gene expression variation with RNA sequencing","volume":"464","author":"Pickrell","year":"2010","journal-title":"Nature,"},{"key":"2021111800101396600_CIT0031","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1126\/science.1174148","article-title":"Common regulatory variation impacts gene expression in a cell type-dependent manner","volume":"325","author":"Dimas","year":"2009","journal-title":"Science,"},{"key":"2021111800101396600_CIT0032","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature14248","article-title":"Integrative analysis of 111 reference human epigenomes","volume":"518","author":"Roadmap Epigenomics Consortium","year":"2015","journal-title":"Nature"},{"key":"2021111800101396600_CIT0033","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1053\/jhep.2002.33161","article-title":"Clinical significance of hepatitis B virus genotypes","volume":"35","author":"Chu","year":"2002","journal-title":"Hepatology,"},{"key":"2021111800101396600_CIT0034","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/hep.24799","article-title":"Genetic variants in human leukocyte antigen\/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development","volume":"55","author":"Hu","year":"2012","journal-title":"Hepatology,"},{"key":"2021111800101396600_CIT0035","doi-asserted-by":"crossref","first-page":"e1003220","DOI":"10.1371\/journal.pgen.1003220","article-title":"Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies","volume":"9","author":"Vijai","year":"2013","journal-title":"PLoS Genet.,"},{"key":"2021111800101396600_CIT0036","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/ng.857","article-title":"CTCF-mediated functional chromatin interactome in pluripotent cells","volume":"43","author":"Handoko","year":"2011","journal-title":"Nat. Genet.,"},{"key":"2021111800101396600_CIT0037","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.cell.2015.11.024","article-title":"CTCF-mediated human 3D genome architecture reveals chromatin topology for transcription","volume":"163","author":"Tang","year":"2015","journal-title":"Cell,"},{"key":"2021111800101396600_CIT0038","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1084\/jem.20071843","article-title":"The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions","volume":"205","author":"Majumder","year":"2008","journal-title":"J. Exp. Med.,"},{"key":"2021111800101396600_CIT0039","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-genom-091212-153455","article-title":"Major histocompatibility complex genomics and human disease","volume":"14","author":"Trowsdale","year":"2013","journal-title":"Annu. Rev. Genomics Hum. Genet.,"},{"key":"2021111800101396600_CIT0040","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nri.2017.143","article-title":"HLA variation and disease","volume":"18","author":"Dendrou","year":"2018","journal-title":"Nat. Rev. Immunol.,"},{"key":"2021111800101396600_CIT0041","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/hep.23943","article-title":"Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma","volume":"52","author":"Clifford","year":"2010","journal-title":"Hepatology,"},{"key":"2021111800101396600_CIT0042","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1111\/liv.14127","article-title":"Integrative analysis identifies genetic variant modulating MICA expression and altering susceptibility to persistent HBV infection","volume":"39","author":"Gong","year":"2019","journal-title":"Liver Int.,"},{"key":"2021111800101396600_CIT0043","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1158\/2159-8290.CD-11-0209","article-title":"The emergence of lncRNAs in cancer biology","volume":"1","author":"Prensner","year":"2011","journal-title":"Cancer Discov.,"},{"key":"2021111800101396600_CIT0044","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jhep.2017.04.009","article-title":"Non-coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets","volume":"67","author":"Klingenberg","year":"2017","journal-title":"J. Hepatol.,"},{"key":"2021111800101396600_CIT0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.canlet.2015.06.017","article-title":"Role of chemokine pathways in hepatobiliary cancer","volume":"379","author":"Ehling","year":"2016","journal-title":"Cancer Lett.,"},{"key":"2021111800101396600_CIT0046","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1055\/s-2006-960171","article-title":"Genomics and signaling pathways in hepatocellular carcinoma","volume":"27","author":"Villanueva","year":"2007","journal-title":"Semin. Liver Dis.,"},{"key":"2021111800101396600_CIT0047","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/cancers12020491","article-title":"Molecular signaling pathways and therapeutic targets in hepatocellular carcinoma","volume":"12","author":"Dimri","year":"2020","journal-title":"Cancers"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/advance-article-pdf\/doi\/10.1093\/carcin\/bgab095\/41043202\/bgab095.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/42\/11\/1347\/41138122\/bgab095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/42\/11\/1347\/41138122\/bgab095.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:16:57Z","timestamp":1637194617000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article\/42\/11\/1347\/6402652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":47,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,10,19]]},"published-print":{"date-parts":[[2021,11,12]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgab095","relation":{},"ISSN":["0143-3334","1460-2180"],"issn-type":[{"type":"print","value":"0143-3334"},{"type":"electronic","value":"1460-2180"}],"subject":[],"published-other":{"date-parts":[[2021,11,1]]},"published":{"date-parts":[[2021,10,19]]}}}