{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:30:20Z","timestamp":1793089820334,"version":"4.5.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clear cell renal cell carcinoma (ccRCC) has been considered a metabolic disease, with loss of von Hippel-Lindau (VHL) gene and consequent overexpression of hypoxia-inducible factor 1 alpha (HIF-1\u03b1), which is central for tumor development and progression. Among other effects, HIF-1\u03b1 is involved in the metabolic reprogramming of cancer cells towards the Warburg effect involved in tumor cell proliferation, migration and survival. In this context, several proteins are expressed by cancer cells, including glucose and lactate transporters as well as different pH regulators. Among them, monocarboxylate transporters (MCTs) can be highlighted. Our aim is to comprehensively analyze the immunoexpression of MCT1, MCT2, MCT4, CD147, CD44, HIF-1\u03b1, GLUT1 and CAIX in ccRCC surgical specimens correlating with classical prognostic factors and survival of patients with long follow-up. Surgical specimens from 207 patients with ccRCC who underwent radical or partial nephrectomy were used to build a tissue microarray. Immunostaining was categorized into absent\/weak or moderate\/strong and related to all classic ccRCC prognostic parameters. Kaplan\u2013Meier curves were generated to assess overall and cancer-specific survival, and multivariate analysis was performed to identify independent prognostic factors of survival. Multivariate analysis showed that MCT1 together with tumor size and TNM staging, were independently related to cancer-specific survival. MCT1, CD147, CD44 and GLUT1 expression were significantly associated with poor prognostic factors. We show that MCT1 is an independent prognostic factor for cancer-specific survival in ccRCC justifying the use of new target therapies already being tested in clinical trials.<\/jats:p>","DOI":"10.1093\/carcin\/bgab100","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T06:44:11Z","timestamp":1634625851000},"page":"1420-1427","source":"Crossref","is-referenced-by-count":12,"title":["MCT1 expression is independently related to shorter cancer-specific survival in clear cell renal cell carcinoma"],"prefix":"10.1093","volume":"42","author":[{"given":"Paulo Afonso","family":"de Carvalho","sequence":"first","affiliation":[{"name":"Faculdade de Medicina da Universidade de Sao Paulo, Laboratory of Medical Investigation (LIM55)\u2014Urology Department, Sao Paulo, Brazil"},{"name":"Instituto do C\u00e2ncer do Estado de Sao Paulo (ICESP), Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-5119","authenticated-orcid":false,"given":"Murilo","family":"Bonatelli","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio Dener","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Instituto do C\u00e2ncer do Estado de Sao Paulo (ICESP), Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Ferreira","family":"Coelho","sequence":"additional","affiliation":[{"name":"Instituto do C\u00e2ncer do Estado de Sao Paulo (ICESP), Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Reis","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de Sao Paulo, Laboratory of Medical Investigation (LIM55)\u2014Urology Department, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Srougi","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de Sao Paulo, Laboratory of Medical Investigation (LIM55)\u2014Urology Department, Sao Paulo, Brazil"},{"name":"Instituto do C\u00e2ncer do Estado de Sao Paulo (ICESP), Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willian Carlos","family":"Nahas","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de Sao Paulo, Laboratory of Medical Investigation (LIM55)\u2014Urology Department, Sao Paulo, Brazil"},{"name":"Instituto do C\u00e2ncer do Estado de Sao Paulo (ICESP), Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil"},{"name":"Barretos School of Health Sciences Dr. Paulo Prata\u2013FACISB, Barretos, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-7730","authenticated-orcid":false,"given":"Katia Ramos Moreira","family":"Leite","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de Sao Paulo, Laboratory of Medical Investigation (LIM55)\u2014Urology Department, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"2022010505440290000_CIT0001","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1158\/0008-5472.CAN-05-3074","article-title":"Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer","volume":"66","author":"Banks","year":"2006","journal-title":"Cancer Res.,"},{"key":"2022010505440290000_CIT0002","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1200\/JCO.2004.05.061","article-title":"Role of VHL gene mutation in human cancer","volume":"22","author":"Kim","year":"2004","journal-title":"J. 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Invest.,"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/carcin\/advance-article-pdf\/doi\/10.1093\/carcin\/bgab100\/41135054\/bgab100.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/42\/12\/1420\/42071445\/bgab100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/42\/12\/1420\/42071445\/bgab100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:44:42Z","timestamp":1641343482000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article\/42\/12\/1420\/6404659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,20]]},"references-count":52,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,10,20]]},"published-print":{"date-parts":[[2021,12,31]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgab100","relation":{},"ISSN":["0143-3334","1460-2180"],"issn-type":[{"value":"0143-3334","type":"print"},{"value":"1460-2180","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12,1]]},"published":{"date-parts":[[2021,10,20]]}}}