{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T10:13:07Z","timestamp":1769249587005,"version":"3.49.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA078609"],"award-info":[{"award-number":["R01 CA078609"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R35 CA197292"],"award-info":[{"award-number":["R35 CA197292"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytomegalovirus (CMV) is a highly prevalent human herpes virus that exerts a strong influence on immune repertoire which may influence cancer risk. We have tested whether CMV immunoglobulin G (IgG) serostatus is associated with immune cell proportions (n = 132 population controls), human papillomavirus (HPV) co-infection and head and neck cancer risk (n = 184 cancer cases and 188 controls) and patient survival. CMV status was not associated with the proportion of Natural Killer cells, B cells or the neutrophil-to-lymphocyte ratio. However, CD8+ T cells increased with increasing categories of IgG titers (P =1.7\u00a0\u00d7\u00a010\u221210), and titers were inversely associated with the CD4:CD8 ratio (P = 5.6\u00a0\u00d7\u00a010\u22125). Despite these differences in T cell proportions, CMV was not associated with HPV16 co-infection. CMV seropositivity was similar in cases (52%) and controls (47%) and was not associated with patient survival (hazard ratio [HR] 1.14, 95% confidence interval [CI]: 0.70 to 1.86). However, those patients with the highest titers had the worst survival (HR 1.91, 95% CI: 1.13 to 3.23). Tumor-based data from The Cancer Genome Atlas demonstrated that the presence of CMV transcripts was associated with worse patient survival (HR 1.79, 95% CI: 0.96 to 2.78). These findings confirm that a history of CMV infection alters T cell proportions, but this does not translate to HPV16 co-infection or head and neck cancer risk. Our data suggest that high titers and active CMV virus in the tumor environment may confer worse survival.<\/jats:p>","DOI":"10.1093\/carcin\/bgac021","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T04:12:01Z","timestamp":1646712721000},"page":"430-436","source":"Crossref","is-referenced-by-count":5,"title":["Human cytomegalovirus alters immune cell profile with potential implications for patient survival in head and neck cancer"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1901-9513","authenticated-orcid":false,"given":"Heather H","family":"Nelson","sequence":"first","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota , Minneapolis, MN , USA"},{"name":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota , Minneapolis, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Contestabile","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota , Minneapolis, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2986-9602","authenticated-orcid":false,"given":"DeVon","family":"Hunter-Schlichting","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota , Minneapolis, MN , USA"},{"name":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota , Minneapolis, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0598-0146","authenticated-orcid":false,"given":"Devin","family":"Koestler","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Kansas Medical Center , Kansas City, KS , USA"},{"name":"University of Kansas Cancer Center , Kansas City, KS , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4720-8306","authenticated-orcid":false,"given":"Michael","family":"Pawlita","sequence":"additional","affiliation":[{"name":"Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0616-6963","authenticated-orcid":false,"given":"Tim","family":"Waterboer","sequence":"additional","affiliation":[{"name":"Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-426X","authenticated-orcid":false,"given":"Brock C","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Geisel School of Medicine at Dartmouth , Lebanon, NH , USA"},{"name":"Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth , Lebanon, NH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-447X","authenticated-orcid":false,"given":"Curtis L","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Geisel School of Medicine at Dartmouth , Lebanon, NH , USA"},{"name":"Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth , Lebanon, NH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0339-4944","authenticated-orcid":false,"given":"Jeffrey S","family":"Miller","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota , Minneapolis, MN , USA"},{"name":"Division of Hematology, Oncology and Transplantation, School of Medicine, University of Minnesota , Minneapolis, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-1600","authenticated-orcid":false,"given":"Karl T","family":"Kelsey","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Brown University , Providence, RI , USA"},{"name":"Department of Pathology and Laboratory Medicine, Brown University , Providence, RI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"2022060416434727200_CIT0001","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/rmv.655","article-title":"Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection.","volume":"20","author":"Cannon","year":"2010","journal-title":"Rev. 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