{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:03:42Z","timestamp":1783703022151,"version":"3.55.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["PAPD, 2018-87"],"award-info":[{"award-number":["PAPD, 2018-87"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Provincial Medical Key Talent Project","award":["ZDRCA2016087"],"award-info":[{"award-number":["ZDRCA2016087"]}]},{"name":"Southeast University-Nanjing Medical University Cooperative Research Project","award":["2017DN03"],"award-info":[{"award-number":["2017DN03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MicroRNA (miR)-23b-3p is known to target various genes that are involved in cancer-related pathways. Exosomes are emerging intercellular communication agents. Exosomes secreted by cancer cells can deliver active molecules to the surrounding stromal cells, thereby influencing the recipient cells and promoting the development of cancers. However, the role of exosomal miR-23b-3p in salivary adenoid cystic carcinoma (SACC) is not yet clear. In this study, we set out to investigate the potential role of cancer-derived exosomal miR-23b-3p-related phosphatase and tensin homolog deleted on chromosome 10 in the alteration of angiogenesis and vascular permeability in SACC. We investigated the effect of exosomal miR-23b-3p on the progression of SACC. In vitro experiments indicated that exosomal miR-23b-3p led to an upregulation of vascular permeability, and reduced expression of tight junction proteins. In addition, exosomal miR-23b-3p also enhanced angiogenesis and migration. Next, the angiogenic effect of exosomal miR-23b-3p was validated in vivo, as it led to an increase in the tumor microvasculature. Furthermore, the growth rate of SACC was faster after injection of exosomes loaded with cholesterol-modified miR-23b-3p in mice. In conclusion, these results revealed that SACC cell-derived exosomes play an important role in promoting angiogenesis and local vascular microleakage of SACC by transporting miR-23b-3p, which suggests that miR-23b-3p in the exosomes may be a potential biomarker for distant metastasis of SACC. This suggests the potential of a novel therapeutic target by delivering anti-miR-23b-3p that focuses on exosomes.<\/jats:p>","DOI":"10.1093\/carcin\/bgac033","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T12:30:35Z","timestamp":1649161835000},"page":"682-692","source":"Crossref","is-referenced-by-count":28,"title":["Exosomal microRNA-23b-3p promotes tumor angiogenesis and metastasis by targeting PTEN in salivary adenoid cystic carcinoma"],"prefix":"10.1093","volume":"43","author":[{"given":"Chen-xing","family":"Hou","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Disease, & Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University , Nanjing 210029 , China"},{"name":"Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University , Nanjing 210029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-nan","family":"Sun","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Disease, & Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University , Nanjing 210029 , China"},{"name":"Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University , Nanjing 210029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Disease, & Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University , Nanjing 210029 , China"},{"name":"Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University , Nanjing 210029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Meng","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Disease, & Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University , Nanjing 210029 , China"},{"name":"Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University , Nanjing 210029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Disease, & Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University , Nanjing 210029 , China"},{"name":"Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University , Nanjing 210029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-hai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Disease, & Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University , Nanjing 210029 , China"},{"name":"Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University , Nanjing 210029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ting","family":"Tang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Disease, & Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University , Nanjing 210029 , China"},{"name":"Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University , Nanjing 210029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-551X","authenticated-orcid":false,"given":"Jin-hai","family":"Ye","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Disease, & Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University , Nanjing 210029 , China"},{"name":"Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University , Nanjing 210029 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"2022083013590277700_CIT0001","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.oraloncology.2015.10.002","article-title":"Salivary adenoid cystic carcinoma in Denmark 1990\u20132005: outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA).","volume":"51","author":"Bj\u00f8rndal","year":"2015","journal-title":"Oral Oncol."},{"key":"2022083013590277700_CIT0002","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1002\/cncr.27408","article-title":"Adenoid cystic carcinoma of the head and neck: incidence and survival trends based on 1973\u20132007 Surveillance, Epidemiology, and End Results data.","volume":"118","author":"Ellington","year":"2012","journal-title":"Cancer"},{"key":"2022083013590277700_CIT0003","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/hed.24740","article-title":"Defining the surgical margins of adenoid cystic carcinoma and their impact on outcome: an international collaborative study.","volume":"39","author":"Amit","year":"2017","journal-title":"Head Neck"},{"key":"2022083013590277700_CIT0004","doi-asserted-by":"crossref","first-page":"296","DOI":"10.14639\/0392-100X-N1729","article-title":"Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.","volume":"41","author":"Cantu","year":"2021","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"2022083013590277700_CIT0005","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejca.2020.01.023","article-title":"A prospective multicentre REFCOR study of 470 cases of head and neck adenoid cystic carcinoma: epidemiology and prognostic factors.","volume":"130","author":"Atallah","year":"2020","journal-title":"Eur. J. 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