{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:51:56Z","timestamp":1779306716193,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974007"],"award-info":[{"award-number":["81974007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CCL18 has recently been implicated in malignancies and is increasingly mentioned as a potential tumoral biomarker and furtherly a molecular target for therapeutic intervention, but its expression and clinical significance in multiple myeloma have not been explored. Serum CCL18 levels were measured by ELISA method in 254 newly diagnosed multiple myeloma (NDMM), 21 monoclonal gammopathy of undetermined significance (MGUS) and 22 healthy adults. The study suggests that the serum CCL18 level in NDMM patients was significantly higher than that in MGUS and healthy adults. High level of CCL18 were associated with advanced ISS and R-ISS stages in MM. Patients with high serum CCL18 displayed a significantly more frequent occurrence of renal impairment and hypercalcemia, while the proportion of achieving complete remission (CR) was lower. More importantly, Cox analysis identified CCL18 and LDH as independent predictors of PFS in MM patients, whereas CCL18, creatinine and LDH were independent predictors of OS. Finally, we show that CCL18 can promote migration and invasion of myeloma cell lines RPMI8226 and MM.1S. CCL18 may play a tumor-promoting role by increasing the migration and invasion abilities of myeloma cells.<\/jats:p>","DOI":"10.1093\/carcin\/bgac097","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T01:41:14Z","timestamp":1669945274000},"page":"38-45","source":"Crossref","is-referenced-by-count":8,"title":["CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5696-3357","authenticated-orcid":false,"given":"Bing","family":"Qiao","sequence":"first","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianwen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junying","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022 , China"},{"name":"Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology , Wuhan, 430022 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022 , China"},{"name":"Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology , Wuhan, 430022 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"2023051504234836000_CIT0001","doi-asserted-by":"crossref","first-page":"17046","DOI":"10.1038\/nrdp.2017.46","article-title":"Multiple myeloma","volume":"3","author":"Kumar","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2023051504234836000_CIT0002","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1182\/blood.2020008734","article-title":"How I treat relapsed multiple myeloma","volume":"139","author":"Kastritis","year":"2022","journal-title":"Blood"},{"key":"2023051504234836000_CIT0003","doi-asserted-by":"crossref","first-page":"e003975","DOI":"10.1136\/jitc-2021-003975","article-title":"Tumor-associated macrophages in multiple myeloma: advances in biology and therapy","volume":"10","author":"Sun","year":"2022","journal-title":"J. ImmunoTher. Cancer"},{"key":"2023051504234836000_CIT0004","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41392-021-00484-9","article-title":"Targeting tumor-associated macrophages to synergize tumor immunotherapy","volume":"6","author":"Xiang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"2023051504234836000_CIT0005","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1165\/rcmb.2015-0012OC","article-title":"Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages","volume":"53","author":"Tarique","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023051504234836000_CIT0006","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cytogfr.2021.03.005","article-title":"The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment","volume":"60","author":"Cardoso","year":"2021","journal-title":"Cytokine Growth Factor Rev."},{"key":"2023051504234836000_CIT0007","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.3390\/cells8121526","article-title":"Tumor-associated macrophages in hematologic malignancies: new insights and targeted therapies","volume":"8","author":"Petty","year":"2019","journal-title":"Cells"},{"key":"2023051504234836000_CIT0008","doi-asserted-by":"crossref","first-page":"7955","DOI":"10.3390\/ijms21217955","article-title":"CCL18 in the progression of cancer","volume":"21","author":"Korbecki","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2023051504234836000_CIT0009","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1182\/blood-2016-01-631200","article-title":"Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group","volume":"127","author":"Sonneveld","year":"2016","journal-title":"Blood"},{"key":"2023051504234836000_CIT0010"},{"key":"2023051504234836000_CIT0011","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/leu.2015.191","article-title":"Tumor-associated macrophages and extracellular matrix metalloproteinase inducer in prognosis of multiple myeloma","volume":"30","author":"Panchabhai","year":"2016","journal-title":"Leukemia"},{"key":"2023051504234836000_CIT0012","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1111\/j.1468-3083.2012.04495.x","article-title":"Increased CCL18 expression in patients with cutaneous T-cell lymphoma: association with disease severity and prognosis","volume":"27","author":"Miyagaki","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"2023051504234836000_CIT0013","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12943-016-0542-2","article-title":"CCL18 from ascites promotes ovarian cancer cell migration through proline-rich tyrosine kinase 2 signaling","volume":"15","author":"Lane","year":"2016","journal-title":"Mol. Cancer"},{"key":"2023051504234836000_CIT0014","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.7150\/jca.37515","article-title":"High serum CCL18 predicts a poor prognosis in patients with laryngeal squamous cell carcinoma","volume":"10","author":"Wang","year":"2019","journal-title":"J. Cancer"},{"key":"2023051504234836000_CIT0015","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3233\/CBM-171097","article-title":"The expression of CCL18 in diffuse large B cell lymphoma and its mechanism research","volume":"21","author":"Zhou","year":"2018","journal-title":"Cancer Biomark."},{"key":"2023051504234836000_CIT0016","doi-asserted-by":"crossref","first-page":"230183","DOI":"10.1155\/2014\/230183","article-title":"CC chemokine ligand 18 correlates with malignant progression of prostate cancer","volume":"2014","author":"Chen","year":"2014","journal-title":"Biomed Res. Int."},{"key":"2023051504234836000_CIT0017","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/1724600819829758","article-title":"The serum level of CC chemokine ligand 18 correlates with the prognosis of non-small cell lung cancer","volume":"34","author":"Huang","year":"2019","journal-title":"Int. J. Biol. Markers"},{"key":"2023051504234836000_CIT0018","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ccr.2011.02.006","article-title":"CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3","volume":"19","author":"Chen","year":"2011","journal-title":"Cancer Cell"},{"key":"2023051504234836000_CIT0019","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.canlet.2019.06.009","article-title":"CCL18-induced HOTAIR upregulation promotes malignant progression in esophageal squamous cell carcinoma through the miR-130a-5p-ZEB1 axis","volume":"460","author":"Wang","year":"2019","journal-title":"Cancer Lett."},{"key":"2023051504234836000_CIT0020","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/s41419-020-02978-w","article-title":"CCL18-induced LINC00319 promotes proliferation and metastasis in oral squamous cell carcinoma via the miR-199a-5p\/FZD4 axis","volume":"11","author":"Jiang","year":"2020","journal-title":"Cell Death Dis."},{"key":"2023051504234836000_CIT0021","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00109-018-1711-0","article-title":"Macrophage-derived CCL18 promotes osteosarcoma proliferation and migration by upregulating the expression of UCA1","volume":"97","author":"Su","year":"2019","journal-title":"J. Mol. Med. (Berl.)"},{"key":"2023051504234836000_CIT0022","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/mc.22419","article-title":"CCL18 from tumor-cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway","volume":"55","author":"Wang","year":"2016","journal-title":"Mol. Carcinog."},{"key":"2023051504234836000_CIT0023","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s13402-018-0410-8","article-title":"CCL18 secreted from M2 macrophages promotes migration and invasion via the PI3K\/Akt pathway in gallbladder cancer","volume":"42","author":"Zhou","year":"2019","journal-title":"Cell. Oncol. (Dordr)"},{"key":"2023051504234836000_CIT0024","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1002\/mc.22450","article-title":"CC chemokine ligand 18(CCL18) promotes migration and invasion of lung cancer cells by binding to Nir1 through Nir1-ELMO1\/DOC180 signaling pathway","volume":"55","author":"Shi","year":"2016","journal-title":"Mol. Carcinog."},{"key":"2023051504234836000_CIT0025","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1080\/15384101.2018.1526602","article-title":"The long non-coding RNA CRNDE competed endogenously with miR-205 to promote proliferation and metastasis of melanoma cells by targeting CCL18","volume":"17","author":"Xu","year":"2018","journal-title":"Cell Cycle"},{"key":"2023051504234836000_CIT0026","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1084\/jem.20130240","article-title":"Identification of human CCR8 as a CCL18 receptor","volume":"210","author":"Islam","year":"2013","journal-title":"J. Exp. Med."},{"key":"2023051504234836000_CIT0027","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/jcp.22284","article-title":"Attenuation of CXCR4 responses by CCL18 in acute lymphocytic leukemia B cells","volume":"225","author":"Catusse","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"2023051504234836000_CIT0028","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1016\/j.ejca.2013.07.146","article-title":"Nir1 promotes invasion of breast cancer cells by binding to chemokine (C-C motif) ligand 18 through the PI3K\/Akt\/GSK3beta\/Snail signalling pathway","volume":"49","author":"Zhang","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"2023051504234836000_CIT0029","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41419-018-0486-0","article-title":"Tumor-associated macrophages promote progression and the Warburg effect via CCL18\/NF-kB\/VCAM-1 pathway in pancreatic ductal adenocarcinoma","volume":"9","author":"Ye","year":"2018","journal-title":"Cell Death Dis."},{"key":"2023051504234836000_CIT0030","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/imcb.12245","article-title":"Macrophage ERalpha promoted invasion of endometrial cancer cell by mTOR\/KIF5B-mediated epithelial to mesenchymal transition","volume":"97","author":"Jing","year":"2019","journal-title":"Immunol. Cell Biol."},{"key":"2023051504234836000_CIT0031","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.blre.2018.11.003","article-title":"The impact of NF-kappaB signaling on pathogenesis and current treatment strategies in multiple myeloma","volume":"34","author":"Vrabel","year":"2019","journal-title":"Blood Rev."},{"key":"2023051504234836000_CIT0032","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s41375-019-0404-1","article-title":"Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options","volume":"33","author":"van Andel","year":"2019","journal-title":"Leukemia"},{"key":"2023051504234836000_CIT0033","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/bjh.14529","article-title":"m-TOR inhibitors and their potential role in haematological malignancies","volume":"177","author":"Calimeri","year":"2017","journal-title":"Br. J. Haematol."},{"key":"2023051504234836000_CIT0034","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13045-018-0615-3","article-title":"Wnt signaling in multiple myeloma: a central player in disease with therapeutic potential","volume":"11","author":"Spaan","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"2023051504234836000_CIT0035","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-pathol-011110-130249","article-title":"Pathogenesis of myeloma","volume":"6","author":"Anderson","year":"2011","journal-title":"Annu. Rev. Pathol."}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/carcin\/advance-article-pdf\/doi\/10.1093\/carcin\/bgac097\/48459648\/bgac097.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/44\/1\/38\/50314144\/bgac097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/44\/1\/38\/50314144\/bgac097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T04:24:15Z","timestamp":1684124655000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article\/44\/1\/38\/6862077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12,1]]},"published-print":{"date-parts":[[2023,5,15]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgac097","relation":{},"ISSN":["0143-3334","1460-2180"],"issn-type":[{"value":"0143-3334","type":"print"},{"value":"1460-2180","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,12,1]]}}}