{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:57:36Z","timestamp":1787662656712,"version":"build-2736575974"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["NIH R01HD096259"],"award-info":[{"award-number":["NIH R01HD096259"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Loss of heterozygosity and promoter hypermethylation of APC is frequently observed in human endometrial cancer, which is the most common gynecological cancer in the USA, but its carcinogenic driver status in the endometrial epithelium has not been confirmed. We have identified a novel population of progenitor endometrial epithelial cells (EECs) in mice that express lysozyme M (LysM) and give rise to approximately 15% of all EECs in adult mice. LysM is a glycoside hydrolase that is encoded by Lyz2 and functions to protect cells from bacteria as part of the innate immune system. Its expression has been shown in a subset of hematopoietic stem cells and in specialized lung and small intestinal epithelial cells. Conditional deletion of Apc in LysM + EECs results in significantly more epithelial cells compared to wild-type mice. At 5 months of age, the ApccKO mice have enlarged uterine horns with pathology that is consistent with endometrial hyperplasia with cystic endometrial glands, non-villous luminal papillae and nuclear atypia. Nuclear accumulation of \u03b2-catenin and ER\u03b1, both of which are known to induce endometrial hyperplasia, was observed in the EECs of the ApccKO mice. These results confirm that loss of APC in EECs can result in a phenotype similar to endometrial hyperplasia.<\/jats:p>","DOI":"10.1093\/carcin\/bgac101","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T21:32:16Z","timestamp":1671744736000},"page":"54-64","source":"Crossref","is-referenced-by-count":1,"title":["Endometrial hyperplasia with loss of APC in a novel population of <i>Lyz2<\/i>-expressing mouse endometrial epithelial cells"],"prefix":"10.1093","volume":"44","author":[{"given":"Susan M","family":"Kitchen-Goosen","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Van Andel Institute , 333 Bostwick NE, Grand Rapids, MI 49503 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Van Andel Institute , 333 Bostwick NE, Grand Rapids, MI 49503 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Good","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Van Andel Institute , 333 Bostwick NE, Grand Rapids, MI 49503 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University , Grand Rapids, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4233-903X","authenticated-orcid":false,"given":"Elissa A","family":"Boguslawski","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Van Andel Institute , 333 Bostwick NE, Grand Rapids, MI 49503 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"West","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Van Andel Institute , 333 Bostwick NE, Grand Rapids, MI 49503 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5261-5301","authenticated-orcid":false,"given":"Bart O","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Van Andel Institute , 333 Bostwick NE, Grand Rapids, MI 49503 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galen","family":"Hostetter","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Van Andel Institute , 333 Bostwick NE, Grand Rapids, MI 49503 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalen W","family":"Agnew","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigation, Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University , East Lansing, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University , Grand Rapids, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur S","family":"Alberts","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Van Andel Institute , 333 Bostwick NE, Grand Rapids, MI 49503 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"2023051504240753300_CIT0001","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1242\/jcs.03485","article-title":"Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene","volume":"120","author":"Aoki","year":"2007","journal-title":"J. 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