{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:59:17Z","timestamp":1780351157531,"version":"3.54.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"High-level Talents Project of Jiangsu Province","award":["2022-3-3-046"],"award-info":[{"award-number":["2022-3-3-046"]}]},{"name":"\u201cTaihu lake\u201d Science and Technology Project of Wuxi","award":["Y20212018"],"award-info":[{"award-number":["Y20212018"]}]},{"name":"First Outstanding Young and Middle-aged Public Health Talents Project of Wuxi","award":["BJ2020025"],"award-info":[{"award-number":["BJ2020025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hepatocellular carcinoma (HCC) exhibits a high mortality rate due to its high invasion and metastatic nature, and the acidic microenvironment plays a pivotal role. Acid-sensing ion channel 1 (ASIC1) is upregulated in HCC tissues and facilitates tumor progression in a pH-dependent manner, while the specific mechanisms therein remain currently unclear. Herein, we aimed to investigate the underlying mechanisms by which ASIC1 contributes to the development of HCC. Using bioinformatics analysis, we found a significant association between ASIC1 expression and malignant transformation of HCC, such as poor prognosis, metastasis and recurrence. Specifically, ASIC1 enhanced the migration and invasion capabilities of Li-7 cells in the in vivo experiment using an HCC lung metastasis mouse model, as well as in the in vitro experiments such as wound healing assay and Transwell assay. Furthermore, our comprehensive gene chip and molecular biology experiments revealed that ASIC1 promoted HCC migration and invasion by activating the PRKACA\/AP-1 signaling pathway. Our findings indicate that targeting ASIC1 could have therapeutic potential for inhibiting HCC progression.<\/jats:p>","DOI":"10.1093\/carcin\/bgae008","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T22:56:06Z","timestamp":1706914566000},"page":"399-408","source":"Crossref","is-referenced-by-count":6,"title":["ASIC1 promotes migration and invasion of hepatocellular carcinoma via the PRKACA\/AP-1 signaling pathway"],"prefix":"10.1093","volume":"45","author":[{"given":"Youyi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"},{"name":"Wuxi School of Medicine, Jiangnan University , Wuxi, Jiangsu 214122 , China"},{"name":"Institute of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boshi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"},{"name":"Wuxi School of Medicine, Jiangnan University , Wuxi, Jiangsu 214122 , China"},{"name":"Institute of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Wuxi School of Medicine, Jiangnan University , Wuxi, Jiangsu 214122 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yipeng","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"},{"name":"Wuxi School of Medicine, Jiangnan University , Wuxi, Jiangsu 214122 , China"},{"name":"Institute of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjian","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"},{"name":"Wuxi School of Medicine, Jiangnan University , Wuxi, Jiangsu 214122 , China"},{"name":"Institute of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"},{"name":"Institute of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youzhao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"},{"name":"Institute of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2847-7157","authenticated-orcid":false,"given":"Cheng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"},{"name":"Wuxi School of Medicine, Jiangnan University , Wuxi, Jiangsu 214122 , China"},{"name":"Institute of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu 214041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"2024061016210757300_CIT0001","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA. 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