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However, the actual detection panels used in the clinic are variable. Current research on tumor microenvironment (TME) of MPLC and IM is insufficient. Therefore, additional investigation into the differential diagnosis and discrepancies in TME between two conditions is crucial. Two hundred and fourteen non-small cell lung cancer patients with multiple tumors were enrolled and 507 samples were subjected to DNA sequencing (NGS 10). Then, DNA and RNA sequencing (master panel) were performed on the specimens from 32 patients, the TME profiles between tumors within each patient and across patients and the differentially expressed genes were compared. Four patients were regrouped with NGS 10 results. Master panel resolved the classifications of six undetermined patients. The TME in MPLC exhibited a high degree of infiltration by natural killer (NK) cells, CD56dim NK cells, endothelial cells, etc., P\u2005&amp;lt;\u20050.05. Conversely, B cells, activated B cells, regulatory cells, immature dendritic cells, etc., P\u2005&amp;lt;\u20050.001, were heavily infiltrated in the IM. NECTIN4 and LILRB4 mRNA were downregulated in the MPLC (P\u2005&amp;lt;\u20050.0001). Additionally, NECTIN4 (P\u2005&amp;lt;\u20050.05) and LILRB4 were linked to improved disease-free survival in the MPLC. In conclusion, IM is screened from MPLC by pathology joint NGS 10 detections, followed by a large NGS panel for indistinguishable patients. A superior prognosis of MPLC may be associated with an immune-activating TME and the downregulation of NECTIN4 and LILRB4 considered as potential drug therapeutic targets.<\/jats:p>","DOI":"10.1093\/carcin\/bgae026","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T06:57:17Z","timestamp":1714633037000},"page":"387-398","source":"Crossref","is-referenced-by-count":5,"title":["Genomic and transcriptomic significance of multiple primary lung cancers detected by next-generation sequencing in clinical settings"],"prefix":"10.1093","volume":"45","author":[{"given":"Meihong","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongliang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guizhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoling","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengtao","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxin","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Economics, Xiamen University , No.422 Siming South Road, Siming District, Xiamen 361005 , Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6370-4150","authenticated-orcid":false,"given":"Yinghong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital , No.29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"2024061016210749500_CIT0001","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1038\/s41598-021-83609-y","article-title":"Mutational landscape of multiple primary lung cancers and its correlation with non-intrinsic risk factors","volume":"11","author":"Izumi","year":"2021","journal-title":"Sci. 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Cancer"},{"key":"2024061016210749500_CIT0051","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3390\/cancers12061429","article-title":"Baseline splenic volume as a prognostic biomarker of FOLFIRI efficacy and a surrogate marker of MDSC accumulation in metastatic colorectal carcinoma","volume":"12","author":"Niogret","year":"2020","journal-title":"Cancers (Basel)"},{"key":"2024061016210749500_CIT0052","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"2024061016210749500_CIT0053","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","article-title":"Tumor angiogenesis: causes, consequences, challenges and opportunities","volume":"77","author":"Lugano","year":"2020","journal-title":"Cell. Mol. 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