{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:43:49Z","timestamp":1791917029287,"version":"4.3.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802705"],"award-info":[{"award-number":["81802705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Funding of Shenzhen","award":["JCYJ20190808155015181"],"award-info":[{"award-number":["JCYJ20190808155015181"]}]},{"name":"Natural Science Funding of Shenzhen","award":["JCYJ20230807142806014"],"award-info":[{"award-number":["JCYJ20230807142806014"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["A2023285"],"award-info":[{"award-number":["A2023285"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["86000000210"],"award-info":[{"award-number":["86000000210"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["71201-000001"],"award-info":[{"award-number":["71201-000001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cisplatin (DDP)-based combined chemotherapy or concurrent chemoradiotherapy is the mainstay treatment for advanced-stage nasopharyngeal carcinoma (NPC), but needs improvement due to its severe side effects. Capsaicin (CAP) can enhance the anti-tumor activity of cytotoxic drugs. The aim of this study was to investigate the anti-metastasis activity of CAP in combination with DDP in NPC. Herein, CAP and DDP showed synergistic cytotoxic effects on NPC cells. CAP alone and DDP alone inhibited NPC migration and invasion in vitro and in vivo, and the combination of CAP and DDP had the greatest effect. Moreover, CAP upregulated the mRNA and protein expressions of serpin family B member 2 (SERPINB2). Further results showed that both SERPINB2 mRNA and protein expressions were downregulated in NPC cell lines and tissues and SERPINB2 overexpression inhibited NPC migration and invasion in vitro and in vivo, while silencing SERPINB2 acted oppositely. In addition, SERPINB2 was abnormally expressed in head and neck squamous cell carcinoma and other multiple cancers, and downregulation of SERPINB2 predicted poor prognosis in head and neck squamous cell carcinoma according to the Cancer Genome Atlas database. We further found that SERPINB2 overexpression inhibited epithelial\u2013mesenchymal transition (EMT) and the phosphorylated extracellular signal-regulated kinase (p-ERK), and the inhibitory effect was enhanced by CAP and DDP. Altogether, our results suggest that the combined inhibition of CAP and DDP on NPC metastasis may be related to the inhibition of epithelial\u2013mesenchymal transition and ERK signals mediated by SERPINB2, and CAP may help to improve the efficacy of DDP in the treatment of NPC and develop new therapeutic approaches.<\/jats:p>","DOI":"10.1093\/carcin\/bgae032","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T07:38:07Z","timestamp":1715931487000},"page":"556-568","source":"Crossref","is-referenced-by-count":7,"title":["Capsaicin enhances cisplatin-induced anti-metastasis of nasopharyngeal carcinoma by inhibiting EMT and ERK signaling via serpin family B member 2"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0178-3102","authenticated-orcid":false,"given":"Yafei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Genetics, Shenzhen University Health Science Center , 1066 Xue Yuan Road, Xili, Nanshan District, Shenzhen, Guangdong 518060 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimiao","family":"Kong","sequence":"additional","affiliation":[{"name":"Shenzhen University Health Science Center Youth Innovation Team of Medical Bioinformatics, , 1066 Xue Yuan Road, Xili, Nanshan District, Shenzhen, Guangdong 518060 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shenzhen University Health Science Center Youth Innovation Team of Medical Bioinformatics, , 1066 Xue Yuan Road, Xili, Nanshan District, Shenzhen, Guangdong 518060 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Medical Laboratory of the Third Affiliated Hospital of Shenzhen University , 47 Youyi Road, Luohu District, Shenzhen, Guangdong 518005 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Genetics, Shenzhen University Health Science Center , 1066 Xue Yuan Road, Xili, Nanshan District, Shenzhen, Guangdong 518060 , China"},{"name":"Shenzhen University Health Science Center Youth Innovation Team of Medical Bioinformatics, , 1066 Xue Yuan Road, Xili, Nanshan District, Shenzhen, Guangdong 518060 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"2024081205510929000_CIT0001","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J 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