{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:32:35Z","timestamp":1790778755159,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82272411"],"award-info":[{"award-number":["82272411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82072363"],"award-info":[{"award-number":["82072363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82102480"],"award-info":[{"award-number":["82102480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangsu Provincial Medical Key Discipline","award":["ZDXK202240"],"award-info":[{"award-number":["ZDXK202240"]}]},{"DOI":"10.13039\/501100004610","name":"Science and Technology Project of Jiangsu Province","doi-asserted-by":"publisher","award":["BE2023741"],"award-info":[{"award-number":["BE2023741"]}],"id":[{"id":"10.13039\/501100004610","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation of Jiangsu Province Research Hospital","award":["YJXYY202204-XKB16"],"award-info":[{"award-number":["YJXYY202204-XKB16"]}]},{"name":"Postgraduate Research & Practice Innovation Program of Jiangsu Province","award":["KYCX24_3585"],"award-info":[{"award-number":["KYCX24_3585"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Since gastric cancer (GC) shows no apparent signs in its early stages, most patients are diagnosed later with a poor prognosis. We therefore seek more sensitive and specific GC biomarkers. Small RNAs formed from tRNAs represent a novel class of non-coding RNAs that are highly abundant in bodily fluids and essential to biological metabolism. This study explores the potential of i-tRF-AsnGTT in gastric cancer diagnostics. To begin with, we sequenced i-tRF-AsnGTT using high-throughput methods. i-tRF-AsnGTT expression levels in GC were determined using real-time fluorescence polymerase chain reaction. Agarose gel electrophoresis, Sanger sequencing, and repeated freezing and thawing were performed to verify molecular properties. A correlation was found between clinical and pathological parameters and i-tRF-AsnGTT expression levels through the \u03c72 test, and receiver operating characteristic was used to analyze its diagnostic value in GC. In serum, i-tRF-AsnGTT has a low and stable expression level. It can differentiate between patients with gastric cancer and gastritis and healthy donors with better diagnostic efficacy. In combination with clinicopathological parameters, i-tRF-AsnGTT correlates with tumor differentiation; infiltration depth of tumors; tumor, node, metastasis stage; lymph node metastases; and neural\/vascular invasion. Serum i-tRF-AsnGTT expression is low in GC patients. Serum from postoperative patients shows increased i-tRF-AsnGTT expression levels. Potentially, this could be used as a biomarker to help diagnose gastric cancer and monitor its prognosis.<\/jats:p>","DOI":"10.1093\/carcin\/bgae044","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T08:18:06Z","timestamp":1721290686000},"source":"Crossref","is-referenced-by-count":4,"title":["Systematic assessment of serum i-tRF-AsnGTT in gastric cancer: a potential clinical biomarker"],"prefix":"10.1093","volume":"46","author":[{"given":"Xiaodan","family":"Jiang","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Nantong University, Medical School of Nantong University Department of Laboratory Medicine, , Nantong 226001 ,","place":["China"]},{"name":"Research Center of Clinical Medicine, Affiliated Hospital of Nantong University , Nantong 226001, Jiangsu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nantong University, Medical School of Nantong University Department of Laboratory Medicine, , Nantong 226001 ,","place":["China"]},{"name":"Research Center of Clinical Medicine, Affiliated Hospital of Nantong University , Nantong 226001, Jiangsu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nantong University, Medical School of Nantong University Department of Laboratory Medicine, , Nantong 226001 ,","place":["China"]},{"name":"Research Center of Clinical Medicine, Affiliated Hospital of Nantong University , Nantong 226001, Jiangsu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nantong University, Medical School of Nantong University Department of Laboratory Medicine, , Nantong 226001 ,","place":["China"]},{"name":"Research Center of Clinical Medicine, Affiliated Hospital of Nantong University , Nantong 226001, Jiangsu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8118-5347","authenticated-orcid":false,"given":"Xinliang","family":"Gu","sequence":"additional","affiliation":[{"name":"General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University , Nanjing\u00a0210006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zong","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nantong University, Medical School of Nantong University Department of Laboratory Medicine, , Nantong 226001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nantong University, Medical School of Nantong University Department of Laboratory Medicine, , Nantong 226001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7448-2020","authenticated-orcid":false,"given":"Shaoqing","family":"Ju","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nantong University, Medical School of Nantong University Department of Laboratory Medicine, , Nantong 226001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"2025030711333083000_CIT0001","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J 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