{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:35:46Z","timestamp":1772138146164,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Australian Government Research Training Program Scholarship; S.S.W. was supported by a Melbourne Research Scholarship; and T.M. was supported by a CASS Foundation Science","award":["065516"],"award-info":[{"award-number":["065516"]}]},{"DOI":"10.13039\/501100000942","name":"Brain Foundation","doi-asserted-by":"publisher","award":["065518"],"award-info":[{"award-number":["065518"]}],"id":[{"id":"10.13039\/501100000942","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Microbiology & Immunology, and the Department of Surgery (RMH), The University of Melbourne"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Testicular tumors are the most common malignancy of young men, and tumors affecting the testis are caused by somatic mutations in germ or germ-like cells. The PI3K pathway is constitutively activated in about one-third of testicular cancers. To investigate the role of the PI3K pathway in transforming stem-like cells in the testis, we investigated tumors derived from mice with post-natal, constitutive activation of PI3K signaling and homozygous deletion of tumor suppressor Pten, targeted to Nestin-expressing cells. Mice developed aggressive tumors, exhibiting heterogeneous histopathology and hemorrhaging. The tumors resemble the rare testis tumor type, testicular sex cord\u2013stromal Leydig cell tumors. Single-cell resolution spatial tissue analysis demonstrated that T-cells are the dominant tumor-infiltrating immune cell type, with very few infiltrating macrophages observed in the tumor tissue, with CD8+ T-cells predominating. Further analysis showed that immune cells preferentially localize to, or accumulate within stromal regions.<\/jats:p>","DOI":"10.1093\/carcin\/bgae077","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T23:40:11Z","timestamp":1733960411000},"source":"Crossref","is-referenced-by-count":0,"title":["Testicular sex cord\u2013stromal tumors in mice with constitutive activation of PI3K and loss of Pten"],"prefix":"10.1093","volume":"46","author":[{"given":"Marija","family":"Dinevska","sequence":"first","affiliation":[{"name":"Department of Surgery (RMH), The University of Melbourne , Parkville, VIC 3052 ,\u00a0","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lachlan","family":"McAloney","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, The University of Melbourne , Parkville, VIC 3052 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel S","family":"Widodo","sequence":"additional","affiliation":[{"name":"Department of Surgery (RMH), The University of Melbourne , Parkville, VIC 3052 ,\u00a0","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulay","family":"Filiz","sequence":"additional","affiliation":[{"name":"School of Biosciences, The University of Melbourne , Parkville, VIC 3052 ,\u00a0","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Anderson","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Royal Children\u2019s Hospital , Flemington Road , Parkville, VIC 3052 ,","place":["Australia"]},{"name":"Department of Paediatrics, The University of Melbourne , Parkville, VIC 3052 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Dworkin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy and Microbiology, La Trobe University , Bundoora, VIC 3086 ,\u00a0","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon P","family":"Windley","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology, The University of Melbourne , Parkville, VIC 3052 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7757-4075","authenticated-orcid":false,"given":"Dagmar","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology, The University of Melbourne , Parkville, VIC 3052 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-5380","authenticated-orcid":false,"given":"Theo","family":"Mantamadiotis","sequence":"additional","affiliation":[{"name":"Department of Surgery (RMH), The University of Melbourne , Parkville, VIC 3052 ,\u00a0","place":["Australia"]},{"name":"Department of Microbiology & Immunology, The University of Melbourne , Parkville, VIC 3052 ,","place":["Australia"]},{"name":"The Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, VIC 3000 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"2025030422450887400_CIT0001","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.eururo.2016.02.029","article-title":"The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs. 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