{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:53:42Z","timestamp":1792223622557,"version":"4.4.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100021778","name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FONCYT-PICT-2021-GRFTI-00543"],"award-info":[{"award-number":["FONCYT-PICT-2021-GRFTI-00543"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas - Argentina","award":["#22920180100043CO"],"award-info":[{"award-number":["#22920180100043CO"]}]},{"name":"Secretar\u00eda de Ciencia y Tecnolog\u00eda de la Universidad Nacional de C\u00f3rdoba","award":["2018-2020: 411\/18, 455\/18 472\/18"],"award-info":[{"award-number":["2018-2020: 411\/18, 455\/18 472\/18"]}]},{"name":"Secretar\u00eda de Ciencia y Tecnolog\u00eda de la Universidad Nacional de C\u00f3rdoba","award":["2018-2020: 411\/18, 455\/18 472\/18"],"award-info":[{"award-number":["2018-2020: 411\/18, 455\/18 472\/18"]}]},{"name":"Secretar\u00eda de Ciencia y Tecnolog\u00eda de la Universidad Nacional de C\u00f3rdoba","award":["2018-2020: 411\/18, 455\/18 472\/18"],"award-info":[{"award-number":["2018-2020: 411\/18, 455\/18 472\/18"]}]},{"name":"Secretar\u00eda de Ciencia y Tecnolog\u00eda de la Universidad Nacional de C\u00f3rdoba","award":["2023-258-E-UNC-SECYT#ACTIP"],"award-info":[{"award-number":["2023-258-E-UNC-SECYT#ACTIP"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pancreatic cancer is a devastating malignancy in great need of new and more effective treatment approaches. In recent years, studies have indicated that nutritional interventions, particularly nutraceuticals, may provide novel avenues to modulate cancer progression. Here, our study characterizes the impact of \u03c9-3 polyunsaturated fatty acids, eicosapentaenoic acid, and docosahexaenoic acid, as a nutraceutical intervention in pancreatic cancer using a genetically engineered mouse model driven by KrasG12D and Trp53R172H. This model closely resembles human pancreatic carcinogenesis, offering a disease relevant platform for translational research. Our findings showed that \u03c9-3 polyunsaturated fatty acids intervention (using a diet supplemented with 6% cod liver oil) significantly reduced tumor volume as well as lung and liver metastasis and a trend toward improved survival rate compared with control treated mice. This antitumoral effect was accompanied by distinct changes in tumor membrane fatty acid profile and eicosanoids release. Furthermore, the eicosapentaenoic acid and docosahexaenoic acid intervention also reduced malignant histological parameters and induced apoptosis without affecting cell proliferation. Of note is the significant reduction in tumor fibrosis that was associated with decreased levels of Sonic Hedgehog, a major ligand controlling this cellular compartment in pancreatic cancer. All together our results demonstrate the impact of eicosapentaenoic acid and docosahexaenoic acid as antitumor regulators in pancreatic cancer, suggesting potential for \u03c9-3 polyunsaturated fatty acids as a possible antitumoral dietary intervention. This research opens new avenues for integrating nutraceutical strategies in pancreatic cancer management.<\/jats:p>","DOI":"10.1093\/carcin\/bgae081","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T11:55:47Z","timestamp":1735732547000},"source":"Crossref","is-referenced-by-count":9,"title":["Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression"],"prefix":"10.1093","volume":"46","author":[{"given":"Mar\u00eda I","family":"Garay","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud, INICSA (CONICET - FCM UNC) , 5016 C\u00f3rdoba,","place":["Argentina"]},{"name":"Instituto de Biolog\u00eda Celular y C\u00e1tedra de Biolog\u00eda Celular, Histolog\u00eda y Embriolog\u00eda, FCM-UNC , 5016 C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Mazo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud, INICSA (CONICET - FCM UNC) , 5016 C\u00f3rdoba,","place":["Argentina"]},{"name":"Instituto de Biolog\u00eda Celular y C\u00e1tedra de Biolog\u00eda Celular, Histolog\u00eda y Embriolog\u00eda, FCM-UNC , 5016 C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud, INICSA (CONICET - FCM UNC) , 5016 C\u00f3rdoba,","place":["Argentina"]},{"name":"Instituto de Biolog\u00eda Celular y C\u00e1tedra de Biolog\u00eda Celular, Histolog\u00eda y Embriolog\u00eda, FCM-UNC , 5016 C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelso N","family":"Barotto","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Celular y C\u00e1tedra de Biolog\u00eda Celular, Histolog\u00eda y Embriolog\u00eda, FCM-UNC , 5016 C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisa","family":"Lagares","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud, INICSA (CONICET - FCM UNC) , 5016 C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda F","family":"Granton","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Celular y C\u00e1tedra de Biolog\u00eda Celular, Histolog\u00eda y Embriolog\u00eda, FCM-UNC , 5016 C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J","family":"Moreira-Espinoza","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Celular y C\u00e1tedra de Biolog\u00eda Celular, Histolog\u00eda y Embriolog\u00eda, FCM-UNC , 5016 C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C","family":"Cremonezzi","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Hospital Nacional de Cl\u00ednicas, FCM-UNC , 5000 C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Comba","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division Neuropathology, Heersink School of Medicine, University of Alabama at Birmingham , Birmingham, AL, 35294,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabel N","family":"Brunotto","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud, INICSA (CONICET - FCM UNC) , 5016 C\u00f3rdoba,","place":["Argentina"]},{"name":"Departamento de Biolog\u00eda Bucal, Facultad de Odontolog\u00eda, UNC , 5016 C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel J","family":"Tolosa","sequence":"additional","affiliation":[{"name":"Schulze Center for Novel Therapeutics, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8089-3907","authenticated-orcid":false,"given":"Mart\u00edn E","family":"Fernandez-Zapico","sequence":"additional","affiliation":[{"name":"Schulze Center for Novel Therapeutics, Mayo Clinic , Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-5415","authenticated-orcid":false,"given":"Mar\u00eda E","family":"Pasqualini","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud, INICSA (CONICET - FCM UNC) , 5016 C\u00f3rdoba,","place":["Argentina"]},{"name":"Instituto de Biolog\u00eda Celular y C\u00e1tedra de Biolog\u00eda Celular, Histolog\u00eda y Embriolog\u00eda, FCM-UNC , 5016 C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,1]]},"reference":[{"key":"2025052300073939500_CIT0001","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2025052300073939500_CIT0002","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1038\/s41598-024-55050-4","article-title":"Polyunsaturated fatty acids-induced ferroptosis suppresses pancreatic cancer growth","volume":"14","author":"Suda","year":"2024","journal-title":"Sci Rep"},{"key":"2025052300073939500_CIT0003","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nutres.2020.12.018","article-title":"Impact of dietary fat composition and quantity in pancreatic carcinogenesis: recent advances and controversies","volume":"88","author":"Wirkus","year":"2021","journal-title":"Nutr Res"},{"key":"2025052300073939500_CIT0004","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ccr.2005.04.023","article-title":"Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice","volume":"7","author":"Hingorani","year":"2005","journal-title":"Cancer Cell"},{"key":"2025052300073939500_CIT0005","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1158\/1940-6207.CAPR-13-0065","article-title":"High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model","volume":"6","author":"Dawson","year":"2013","journal-title":"Cancer Prev Res (Phila)"},{"key":"2025052300073939500_CIT0006","doi-asserted-by":"publisher","first-page":"109690","DOI":"10.1016\/j.jnutbio.2024.109690","article-title":"A high-fat diet induces changes in mesenteric adipose tissue accelerating early-stage pancreatic carcinogenesis in mice","volume":"131","author":"Ead","year":"2024","journal-title":"J Nutr Biochem"},{"key":"2025052300073939500_CIT0007","doi-asserted-by":"publisher","first-page":"11691","DOI":"10.3390\/ijms241411691","article-title":"The involvement of polyunsaturated fatty acids in apoptosis mechanisms and their implications in cancer","volume":"24","author":"Montecillo-Aguado","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025052300073939500_CIT0008","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/261247","article-title":"The multifaceted effects of omega-3 polyunsaturated fatty acids on the hallmarks of cancer","volume":"2013","author":"Stephenson","year":"2013","journal-title":"JLipids"},{"key":"2025052300073939500_CIT0009","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1002\/jcb.24354","article-title":"EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction","volume":"114","author":"Fukui","year":"2013","journal-title":"J Cell Biochem"},{"key":"2025052300073939500_CIT0010","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3390\/md21010039","article-title":"N-3 PUFA deficiency aggravates streptozotocin-induced pancreatic injury in mice but dietary supplementation with DHA\/EPA protects the pancreas via suppressing inflammation, oxidative stress and apoptosis","volume":"21","author":"Zou","year":"2023","journal-title":"Mar Drugs"},{"key":"2025052300073939500_CIT0011","doi-asserted-by":"publisher","first-page":"14.39.1","DOI":"10.1002\/cpph.2","article-title":"Genetically engineered mouse models of pancreatic cancer: the KPC model (LSL-Kras G12D\/+;LSL-Trp53R172H\/+;Pdx-1-Cre), its variants, and their application in immuno-oncology drug discovery","volume":"73","author":"Lee","year":"2016","journal-title":"Curr Protoc Pharmacol"},{"key":"2025052300073939500_CIT0012","doi-asserted-by":"publisher","first-page":"106564","DOI":"10.1016\/j.prostaglandins.2021.106564","article-title":"Tumorigenic effect mediated by ROS\/eicosanoids and their regulation on TP53 expression in a murine mammary gland adenocarcinoma","volume":"155","author":"Garay","year":"2021","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"2025052300073939500_CIT0013","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1074\/jbc.M115.691972","article-title":"Nuclear factor of activated T cells-dependent downregulation of the transcription factor glioma-associated protein 1 (GLI1) underlies the growth inhibitory properties of arachidonic acid","volume":"291","author":"Comba","year":"2016","journal-title":"J Biol Chem"},{"key":"2025052300073939500_CIT0014","article-title":"Saturated, cis-monounsaturated, and cis-polyunsaturated fatty acids in marine and other oils containing long chain polyunsaturated fatty acids (PUFAs) by capillary GLC","volume-title":"Official Methods and Recommended Practices of the American Oil Chemists\u2019 Society","author":"American Oil Chemists\u2019 Society","year":"1998","edition":"5th edn"},{"key":"2025052300073939500_CIT0015","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3892\/or.2023.8498","article-title":"Use of time\u2011density curves of dynamic contrast\u2011enhanced computed tomography for determination of the histological therapeutic effects of neoadjuvant chemotherapy for pancreatic ductal adenocarcinoma","volume":"49","author":"Goto","year":"2023","journal-title":"Oncol Rep"},{"key":"2025052300073939500_CIT0016","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.nut.2014.06.001","article-title":"Synergistic anti-tumor effects of melatonin and PUFAs from walnuts in a murine mammary adenocarcinoma model","volume":"31","author":"Garc\u00eda","year":"2015","journal-title":"Nutrition"},{"key":"2025052300073939500_CIT0017","volume-title":"ImageJ","author":"Rasband","year":"1997-2018"},{"key":"2025052300073939500_CIT0018","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-1-61779-860-3_5","article-title":"Detection of apoptosis by TUNEL assay","volume-title":"Odontogenesis. Methods in Molecular Biology","author":"Kyrylkova","year":"2012"},{"key":"2025052300073939500_CIT0019","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.plefa.2017.08.004","article-title":"The effects of \u03c9\u22126 and \u03c9\u22123 fatty-acids on early stages of mice DMBA submandibular glands tumorigenesis","volume":"125","author":"Scherma","year":"2017","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"2025052300073939500_CIT0020","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s00394-015-1096-6","article-title":"Increased dietary levels of \u03b1-linoleic acid inhibit mammary tumor growth and metastasis","volume":"56","author":"Vara-Messler","year":"2017","journal-title":"Eur J Nutr"},{"key":"2025052300073939500_CIT0021","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"2025052300073939500_CIT0022","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1593\/neo.09334","article-title":"Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes","volume":"11","author":"Kelavkar","year":"2009","journal-title":"Neoplasia"},{"key":"2025052300073939500_CIT0023","doi-asserted-by":"publisher","first-page":"25325","DOI":"10.1074\/jbc.M112.370809","article-title":"Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells","volume":"287","author":"Lo R\u00e9","year":"2012","journal-title":"J Biol Chem"},{"key":"2025052300073939500_CIT0024","article-title":"R: a language and environment for statistical computing","volume-title":".","author":"R Core Team","year":"2024"},{"key":"2025052300073939500_CIT0025","volume-title":"InfoStat versi\u00f3n 2012","author":"Di Rienzo","year":"2012"},{"key":"2025052300073939500_CIT0026","doi-asserted-by":"publisher","first-page":"109648","DOI":"10.1016\/j.jnutbio.2024.109648","article-title":"EPA and DHA differentially improve insulin resistance by reducing adipose tissue inflammation\u2014targeting GPR120\/PPAR\u03b3 pathway","volume":"130","author":"Yang","year":"2024","journal-title":"J Nutr Biochem"},{"key":"2025052300073939500_CIT0027","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","article-title":"Pancreatic cancer","volume":"395","author":"Mizrahi","year":"2020","journal-title":"Lancet"},{"key":"2025052300073939500_CIT0028","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/978-3-031-61238-1_6","article-title":"Gastrointestinal malignancies: pancreatic cancer clinical trials in neoadjuvant chemotherapy","volume-title":"Gastrointestinal Malignancies. Cancer Treatment and Research","author":"Barrios","year":"2024"},{"key":"2025052300073939500_CIT0029","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-3-031-61238-1_4","article-title":"Modern treatment strategies for borderline resectable pancreatic cancer","volume-title":"Gastrointestinal Malignancies. Cancer Treatment and Research","author":"Vitello","year":"2024"},{"key":"2025052300073939500_CIT0030","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.3390\/nu13113801","article-title":"Natural products for pancreatic cancer treatment: from traditional medicine to modern drug discovery","volume":"13","author":"Kim","year":"2021","journal-title":"Nutrients"},{"key":"2025052300073939500_CIT0031","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.21873\/anticanres.12485","article-title":"Effects of \u03c9-3 fatty acid supplementation in patients with bile duct or pancreatic cancer undergoing chemotherapy","volume":"38","author":"Abe","year":"2018","journal-title":"Anticancer Res"},{"key":"2025052300073939500_CIT0032","doi-asserted-by":"publisher","first-page":"172","DOI":"10.21037\/atm.2020.02.02","article-title":"Myeloid derived suppressor cells are reduced and T regulatory cells stabilised in patients with advanced pancreatic cancer treated with gemcitabine and intravenous omega 3","volume":"8","author":"Isherwood","year":"2020","journal-title":"Ann Transl Med"},{"key":"2025052300073939500_CIT0033","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.3390\/nu10091289","article-title":"Omega-3 fatty acids prevent early pancreatic carcinogenesis via repression of the AKT pathway","volume":"10","author":"Ding","year":"2018","journal-title":"Nutrients"},{"key":"2025052300073939500_CIT0034","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1101\/gad.351863.124","article-title":"Genetics and biology of pancreatic ductal adenocarcinoma","volume":"38","author":"Ying","year":"2024","journal-title":"Genes Dev"},{"key":"2025052300073939500_CIT0035","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/bs.acr.2023.02.002","article-title":"In vivo models of pancreatic ductal adenocarcinoma","volume-title":"Advances in Cancer Research","author":"Vudatha","year":"2023"},{"key":"2025052300073939500_CIT0036","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1093\/jnci\/81.11.858","article-title":"Effect of dietary omega-3 and omega-6 fatty acids on development of azaserine-induced preneoplastic lesions in rat pancreas","volume":"81","author":"O\u2019Connor","year":"1989","journal-title":"J Natl Cancer Inst"},{"key":"2025052300073939500_CIT0037","doi-asserted-by":"publisher","first-page":"100142","DOI":"10.1016\/j.meafoo.2024.100142","article-title":"Advances in therapeutic applications of fish oil: a review","volume":"13","author":"Das","year":"2024","journal-title":"MeasFood"},{"key":"2025052300073939500_CIT0038","doi-asserted-by":"publisher","first-page":"10208","DOI":"10.1038\/s41598-019-46634-6","article-title":"Integrated targeted metabolomic and lipidomic analysis: a novel approach to classifying early cystic precursors to invasive pancreatic cancer","volume":"9","author":"Gaiser","year":"2019","journal-title":"Sci Rep"},{"key":"2025052300073939500_CIT0039","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1042\/CS20190587","article-title":"Fatty acid oxidation inhibitor etomoxir suppresses tumor progression and induces cell cycle arrest via PPAR\u03b3-mediated pathway in bladder cancer","volume":"133","author":"Cheng","year":"2019","journal-title":"Clin Sci"},{"key":"2025052300073939500_CIT0040","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1093\/abbs\/gmy045","article-title":"Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway","volume":"50","author":"Song","year":"2018","journal-title":"Acta Biochim Biophys Sin"},{"key":"2025052300073939500_CIT0041","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3892\/mmr.2024.13233","article-title":"Pancreatic stellate cells: key players in pancreatic health and diseases (Review)","volume":"30","author":"Wang","year":"2024","journal-title":"Mol Med Rep"},{"key":"2025052300073939500_CIT0042","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.3892\/etm.2019.8324","article-title":"Saikosaponin a attenuates hyperlipidemic pancreatitis in rats via the PPAR\u2011\u03b3\/NF\u2011\u03baB signaling pathway","volume":"19","author":"Feng","year":"2020","journal-title":"Exp Ther Med"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/carcin\/advance-article-pdf\/doi\/10.1093\/carcin\/bgae081\/61307204\/bgae081.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/46\/1\/bgae081\/61307204\/bgae081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/46\/1\/bgae081\/61307204\/bgae081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T04:07:50Z","timestamp":1747973270000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article\/doi\/10.1093\/carcin\/bgae081\/7937160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,20]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgae081","relation":{},"ISSN":["0143-3334","1460-2180"],"issn-type":[{"value":"0143-3334","type":"print"},{"value":"1460-2180","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2025,1,1]]},"article-number":"bgae081"}}