{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:47:07Z","timestamp":1787662027995,"version":"build-2736575974"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270214"],"award-info":[{"award-number":["82270214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470205"],"award-info":[{"award-number":["82470205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Macrophage migration inhibitory factor (MIF) emerged in recent years as an important cytokine with a pleiotropic spectrum of biological functions implicated in the pathogenesis of inflammatory diseases and malignancies. A growing body of research indicates that the overexpression of MIF is prevalent across a variety of solid tumors. Howbeit, there are fewer studies regarding the expression and clinical significance of serum MIF in multiple myeloma (MM) patients. In this study, we investigated the clinical significance of serum MIF in newly diagnosed MM (NDMM) patients and explored the effect of exogenous MIF on the proliferation, migration, and invasion of MM cells in vitro. Herein, our study revealed that NDMM patients exhibited markedly elevated serum MIF levels compared to healthy adults. High levels of MIF were associated with advanced International Staging System (ISS) stage and the Second Revision of the International Staging System (R2-ISS) stage. Besides, NDMM patients with high levels of MIF were prone to have a higher incidence of hypercalcemia, renal insufficiency, high tumor burden, and extramedullary lesions. Moreover, we found that serum MIF, creatinine, and lactate dehydrogenase levels were independent risk factors for predicting poor progression-free survival and overall survival in NDMM patients. Meanwhile, in vitro experiments revealed that MIF can promote the proliferation of MM cells and enhance their migration and invasion. Our study confirmed that NDMM patients with high serum MIF levels showed poor clinical characteristics and inferior prognosis. Therefore, MIF may serve as a promising biomarker in the clinical practice of MM.<\/jats:p>","DOI":"10.1093\/carcin\/bgaf033","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T07:39:58Z","timestamp":1751355598000},"source":"Crossref","is-referenced-by-count":4,"title":["Macrophage migration inhibitory factor as a prognostic biomarker in multiple myeloma: clinical significance and <i>in vitro<\/i> effects"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7096-0102","authenticated-orcid":false,"given":"Dehu","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5696-3357","authenticated-orcid":false,"given":"Bing","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Zhengzhou University , \u00a0 Zhengzhou 450052 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3825-0094","authenticated-orcid":false,"given":"Qianwen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7110-892X","authenticated-orcid":false,"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2279-2024","authenticated-orcid":false,"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-8790","authenticated-orcid":false,"given":"Liping","family":"Zuo","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1009-7066","authenticated-orcid":false,"given":"Qun","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-025X","authenticated-orcid":false,"given":"Chunyan","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"2025071701413285700_CIT0001","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41572-024-00529-7","article-title":"Multiple myeloma","volume":"10","author":"Malard","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"2025071701413285700_CIT0002","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1002\/ajh.27422","article-title":"Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management","volume":"99","author":"Rajkumar","year":"2024","journal-title":"Am J Hematol"},{"key":"2025071701413285700_CIT0003","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.1038\/s41375-020-01051-x","article-title":"Changing paradigms in diagnosis and treatment of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM)","volume":"34","author":"Ho","year":"2020","journal-title":"Leukemia"},{"key":"2025071701413285700_CIT0004","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.ccell.2023.05.007","article-title":"Single cell clonotypic and transcriptional evolution of multiple myeloma precursor disease","volume":"41","author":"Dang","year":"2023","journal-title":"Cancer Cell"},{"key":"2025071701413285700_CIT0005","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1200\/JCO.18.02096","article-title":"Treatment of multiple myeloma: ASCO and CCO Joint Clinical Practice Guideline","volume":"37","author":"Mikhael","year":"2019","journal-title":"J Clin Oncol"},{"key":"2025071701413285700_CIT0006","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1146\/annurev-med-050522-033815","article-title":"New biological therapies for multiple myeloma","volume":"75","author":"Garfall","year":"2024","journal-title":"Annu Rev Med"},{"key":"2025071701413285700_CIT0007","doi-asserted-by":"publisher","first-page":"m3176","DOI":"10.1136\/bmj.m3176","article-title":"Emerging immunotherapies in multiple myeloma","volume":"370","author":"Shah","year":"2020","journal-title":"BMJ (Clin Res Ed)"},{"key":"2025071701413285700_CIT0008","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.trecan.2024.06.002","article-title":"Targeting cancer stem cells in multiple myeloma","volume":"10","author":"Gunes","year":"2024","journal-title":"Trends Cancer"},{"key":"2025071701413285700_CIT0009","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/s41571-018-0018-y","article-title":"The multiple myelomas\u2014current concepts in cytogenetic classification and therapy","volume":"15","author":"Kumar","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"2025071701413285700_CIT0010","doi-asserted-by":"publisher","first-page":"108024","DOI":"10.1016\/j.pharmthera.2021.108024","article-title":"Macrophage migration inhibitory factor (MIF): a multifaceted cytokine regulated by genetic and physiological strategies","volume":"233","author":"Sumaiya","year":"2022","journal-title":"Pharmacol Ther"},{"key":"2025071701413285700_CIT0011","doi-asserted-by":"publisher","first-page":"4497","DOI":"10.1096\/fj.15-273904","article-title":"MIF interacts with CXCR7 to promote receptor internalization, ERK1\/2 and ZAP-70 signaling, and lymphocyte chemotaxis","volume":"29","author":"Alampour-Rajabi","year":"2015","journal-title":"FASEB J"},{"key":"2025071701413285700_CIT0012","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1016\/j.febslet.2009.07.058","article-title":"A functional heteromeric MIF receptor formed by CD74 and CXCR4","volume":"583","author":"Schwartz","year":"2009","journal-title":"FEBS Lett"},{"key":"2025071701413285700_CIT0013","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1126\/science.153.3731.80","article-title":"Mechanism of a reaction in vitro associated with delayed-type hypersensitivity","volume":"153","author":"Bloom","year":"1966","journal-title":"Science"},{"key":"2025071701413285700_CIT0014","doi-asserted-by":"publisher","first-page":"e005475","DOI":"10.1136\/jitc-2022-005475","article-title":"OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases","volume":"10","author":"Thiele","year":"2022","journal-title":"J ImmunoTher Cancer"},{"key":"2025071701413285700_CIT0015","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s10020-024-01005-4","article-title":"MIF promotes Th17 cell differentiation in rheumatoid arthritis through ATF6 signal pathway","volume":"30","author":"Yan","year":"2024","journal-title":"Mol Med"},{"key":"2025071701413285700_CIT0016","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1158\/0008-5472.CAN-23-2390","article-title":"Breast cancer stem cells secrete MIF to mediate tumor metabolic reprogramming that drives immune evasion","volume":"84","author":"Yan","year":"2024","journal-title":"Cancer Res"},{"key":"2025071701413285700_CIT0017","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s13046-024-03024-9","article-title":"Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain metastasis in NSCLC via synergistically promoting microglia M1 polarization","volume":"43","author":"Liu","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"2025071701413285700_CIT0018","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41419-022-04552-y","article-title":"Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma","volume":"13","author":"Fukuda","year":"2022","journal-title":"Cell Death Dis"},{"key":"2025071701413285700_CIT0019","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41421-023-00529-z","article-title":"CD36(+) cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor","volume":"9","author":"Zhu","year":"2023","journal-title":"Cell Discov"},{"key":"2025071701413285700_CIT0020","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41420-024-01924-5","article-title":"Macrophage migration inhibitory factor blockade reprograms macrophages and disrupts prosurvival signaling in acute myeloid leukemia","volume":"10","author":"Spertini","year":"2024","journal-title":"Cell Death Discov"},{"key":"2025071701413285700_CIT0021","doi-asserted-by":"publisher","first-page":"djw131","DOI":"10.1093\/jnci\/djw131","article-title":"Role of myeloma-derived MIF in myeloma cell adhesion to bone marrow and chemotherapy response","volume":"108","author":"Zheng","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"2025071701413285700_CIT0022","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1182\/blood.2020005795","article-title":"MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma","volume":"136","author":"Wang","year":"2020","journal-title":"Blood"},{"key":"2025071701413285700_CIT0023","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.canlet.2017.06.011","article-title":"Macrophage migration inhibitory factor promotes osteosarcoma growth and lung metastasis through activating the RAS\/MAPK pathway","volume":"403","author":"Wang","year":"2017","journal-title":"Cancer Lett"},{"key":"2025071701413285700_CIT0024","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/s41419-020-02992-y","article-title":"Macrophage migration inhibitory factor inhibition as a novel therapeutic approach against triple-negative breast cancer","volume":"11","author":"Charan","year":"2020","journal-title":"Cell Death Dis"},{"key":"2025071701413285700_CIT0025","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1002\/mc.23067","article-title":"Macrophage migration inhibitory factor promotes the invasion and metastasis of oral squamous cell carcinoma through matrix metalloprotein-2\/9","volume":"58","author":"Wang","year":"2019","journal-title":"Mol Carcinog"},{"key":"2025071701413285700_CIT0026","doi-asserted-by":"publisher","first-page":"694331","DOI":"10.3389\/fonc.2021.694331","article-title":"Intratumor heterogeneity of MIF expression correlates with extramedullary involvement of multiple myeloma","volume":"11","author":"Xu","year":"2021","journal-title":"Front Oncol"},{"key":"2025071701413285700_CIT0027","doi-asserted-by":"publisher","first-page":"4669","DOI":"10.1182\/blood-2023-180085","article-title":"The role of macrophage migration inhibitory factor (MIF) in regulation of T-cell activity in multiple myeloma","volume":"142","author":"Gunes","year":"2023","journal-title":"Blood"},{"key":"2025071701413285700_CIT0028","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1182\/blood.v126.23.2988.2988","article-title":"Macrophage migration inhibitory factor drives multiple myeloma IL-6\/8 pro-survival signals in the tumor microenvironment","volume":"126","author":"Piddock","year":"2015","journal-title":"Blood"},{"key":"2025071701413285700_CIT0029","doi-asserted-by":"publisher","first-page":"e206","DOI":"10.1016\/S1470-2045(17)30189-4","article-title":"Role of (18)F-FDG PET\/CT in the diagnosis and management of multiple myeloma and other plasma cell disorders: a consensus statement by the International Myeloma Working Group","volume":"18","author":"Cavo","year":"2017","journal-title":"Lancet Oncol"},{"key":"2025071701413285700_CIT0030","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1097\/RLU.0b013e31825b2071","article-title":"FDG PET or PET\/CT for detecting intramedullary and extramedullary lesions in multiple myeloma: a systematic review and meta-analysis","volume":"37","author":"Lu","year":"2012","journal-title":"Clin Nucl Med"},{"key":"2025071701413285700_CIT0031","doi-asserted-by":"publisher","first-page":"639528","DOI":"10.3389\/fonc.2021.639528","article-title":"Circulating plasma cells as a biomarker to predict newly diagnosed multiple myeloma prognosis: developing nomogram prognostic models","volume":"11","author":"Cheng","year":"2021","journal-title":"Front Oncol"},{"key":"2025071701413285700_CIT0032","doi-asserted-by":"publisher","first-page":"102054","DOI":"10.1016\/j.omtn.2023.102054","article-title":"MicroRNA-451a inhibits gemcitabine-refractory biliary tract cancer progression by suppressing the MIF-mediated PI3K\/AKT pathway","volume":"34","author":"Obata","year":"2023","journal-title":"Mol Ther Nucleic Acids"},{"key":"2025071701413285700_CIT0033","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1038\/jid.2015.204","article-title":"Cell surface CD74-MIF interactions drive melanoma survival in response to interferon-\u03b3","volume":"135","author":"Tanese","year":"2015","journal-title":"J Invest Dermatol"},{"key":"2025071701413285700_CIT0034","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41419-021-03426-z","article-title":"Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer","volume":"12","author":"Klemke","year":"2021","journal-title":"Cell Death Dis"},{"key":"2025071701413285700_CIT0035","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41375-019-0486-9","article-title":"The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation","volume":"34","author":"Frenquelli","year":"2020","journal-title":"Leukemia"},{"key":"2025071701413285700_CIT0036","doi-asserted-by":"publisher","first-page":"117503","DOI":"10.1016\/j.lfs.2020.117503","article-title":"IGF-1 promotes multiple myeloma progression through PI3K\/Akt-mediated epithelial-mesenchymal transition","volume":"249","author":"Peng","year":"2020","journal-title":"Life Sci"},{"key":"2025071701413285700_CIT0037","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1038\/s41388-022-02191-3","article-title":"YTHDF2 promotes multiple myeloma cell proliferation via STAT5A\/MAP2K2\/p-ERK axis","volume":"41","author":"Hua","year":"2022","journal-title":"Oncogene"},{"key":"2025071701413285700_CIT0038","doi-asserted-by":"publisher","first-page":"eabg2697","DOI":"10.1126\/sciadv.abg2697","article-title":"ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment","volume":"7","author":"Liu","year":"2021","journal-title":"Sci Adv"},{"key":"2025071701413285700_CIT0039","doi-asserted-by":"publisher","first-page":"167345","DOI":"10.1016\/j.bbadis.2024.167345","article-title":"Host derived macrophage migration inhibitory factor expression attenuates anti-tumoral immune cell accumulation and promotes immunosuppression in the tumor microenvironment of head and neck squamous cell carcinoma","volume":"1870","author":"Ryan","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2025071701413285700_CIT0040","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1093\/carcin\/bgae025","article-title":"MIF\/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK-ERK and AP-1 pathways","volume":"45","author":"Yang","year":"2024","journal-title":"Carcinogenesis"},{"key":"2025071701413285700_CIT0041","doi-asserted-by":"publisher","first-page":"e22449","DOI":"10.1096\/fj.202101953R","article-title":"MIF confers survival advantage to pancreatic CAFs by suppressing interferon pathway-induced p53-dependent apoptosis","volume":"36","author":"Suresh","year":"2022","journal-title":"FASEB J"},{"key":"2025071701413285700_CIT0042","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.3389\/fimmu.2018.01132","article-title":"Blockade of MIF-CD74 signalling on macrophages and dendritic cells restores the antitumour immune response against metastatic melanoma","volume":"9","author":"Figueiredo","year":"2018","journal-title":"Front Immunol"},{"key":"2025071701413285700_CIT0043","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13045-018-0614-4","article-title":"Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC","volume":"11","author":"Piddock","year":"2018","journal-title":"J Hematol Oncol"},{"key":"2025071701413285700_CIT0044","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1200\/JCO.2005.04.242","article-title":"International Staging System for multiple myeloma","volume":"23","author":"Greipp","year":"2005","journal-title":"J Clin Oncol"},{"key":"2025071701413285700_CIT0045","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1200\/JCO.21.02614","article-title":"Second Revision of the International Staging System (R2-ISS) for overall survival in multiple myeloma: a European Myeloma Network (EMN) report within the HARMONY Project","volume":"40","author":"D\u2019Agostino","year":"2022","journal-title":"J Clin Oncol"},{"key":"2025071701413285700_CIT0046","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1186\/ar2168","article-title":"Multiple myeloma\/hypercalcemia","volume":"9","author":"Oyajobi","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"2025071701413285700_CIT0047","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/mc.23272","article-title":"Association of RANK and RANKL gene polymorphism with survival and calcium levels in multiple myeloma","volume":"60","author":"\u0141acina","year":"2021","journal-title":"Mol Carcinog"},{"key":"2025071701413285700_CIT0048","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.metabol.2017.11.012","article-title":"Biology and treatment of myeloma related bone disease","volume":"80","author":"Terpos","year":"2018","journal-title":"Metab Clin Exp"},{"key":"2025071701413285700_CIT0049","doi-asserted-by":"publisher","first-page":"R43","DOI":"10.1186\/ar3279","article-title":"Macrophage migration inhibitory factor enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis","volume":"13","author":"Kim","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"2025071701413285700_CIT0050","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1002\/jbmr.2854","article-title":"Macrophage migration inhibitory factor (MIF) supports homing of osteoclast precursors to peripheral osteolytic lesions","volume":"31","author":"Movila","year":"2016","journal-title":"J Bone Miner Res"},{"key":"2025071701413285700_CIT0051","doi-asserted-by":"publisher","first-page":"e415","DOI":"10.1016\/j.clml.2019.05.010","article-title":"Renal impairment at diagnosis in myeloma: patient characteristics, treatment, and impact on outcomes. Results from the Australia and New Zealand Myeloma and Related Diseases Registry","volume":"19","author":"Ho","year":"2019","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"2025071701413285700_CIT0052","doi-asserted-by":"publisher","first-page":"e293","DOI":"10.1016\/S1470-2045(23)00223-1","article-title":"Management of multiple myeloma-related renal impairment: recommendations from the International Myeloma Working Group","volume":"24","author":"Dimopoulos","year":"2023","journal-title":"Lancet Oncol"},{"key":"2025071701413285700_CIT0053","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41419-024-06826-z","article-title":"Macrophage migration inhibitory factor (MIF) suppresses mitophagy through disturbing the protein interaction of PINK1-Parkin in sepsis-associated acute kidney injury","volume":"15","author":"Li","year":"2024","journal-title":"Cell Death Dis"},{"key":"2025071701413285700_CIT0054","doi-asserted-by":"publisher","first-page":"1361343","DOI":"10.3389\/fimmu.2024.1361343","article-title":"Macrophage-derived macrophage migration inhibitory factor mediates renal injury in anti-glomerular basement membrane glomerulonephritis","volume":"15","author":"Yang","year":"2024","journal-title":"Front Immunol"},{"key":"2025071701413285700_CIT0055","doi-asserted-by":"publisher","first-page":"107555","DOI":"10.1016\/j.intimp.2021.107555","article-title":"MIF inhibitor ISO-1 alleviates severe acute pancreatitis-associated acute kidney injury by suppressing the NLRP3 inflammasome signaling pathway","volume":"96","author":"Liu","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"2025071701413285700_CIT0056","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1200\/JCO.2015.65.0044","article-title":"International Myeloma Working Group Recommendations for the diagnosis and management of myeloma-related renal impairment","volume":"34","author":"Dimopoulos","year":"2016","journal-title":"J Clin Oncol"},{"key":"2025071701413285700_CIT0057","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10120-022-01338-1","article-title":"Soluble factors in malignant ascites promote the metastatic adhesion of gastric adenocarcinoma cells","volume":"26","author":"Al-Marzouki","year":"2023","journal-title":"Gastric Cancer"},{"key":"2025071701413285700_CIT0058","doi-asserted-by":"publisher","first-page":"106","DOI":"10.7150\/ijms.7264","article-title":"Increased expression of macrophage migration inhibitory factor and DJ-1 contribute to cell invasion and metastasis of nasopharyngeal carcinoma","volume":"11","author":"Pei","year":"2014","journal-title":"Int J Med Sci"},{"key":"2025071701413285700_CIT0059","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1530\/ERC-12-0286","article-title":"Release of macrophage migration inhibitory factor by neuroendocrine-differentiated LNCaP cells sustains the proliferation and survival of prostate cancer cells","volume":"20","author":"Tawadros","year":"2013","journal-title":"Endocr Relat Cancer"},{"key":"2025071701413285700_CIT0060","doi-asserted-by":"publisher","first-page":"5541","DOI":"10.3748\/wjg.15.5541","article-title":"Macrophage migration inhibitory factor regulates proliferation of gastric cancer cells via the PI3K\/Akt pathway","volume":"15","author":"Li","year":"2009","journal-title":"World J Gastroenterol"},{"key":"2025071701413285700_CIT0061","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/ijc.27736","article-title":"Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma","volume":"132","author":"Funamizu","year":"2013","journal-title":"Int J Cancer"},{"key":"2025071701413285700_CIT0062","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.3892\/or.2018.6703","article-title":"Upregulation of macrophage migration inhibitory factor promotes tumor metastasis and correlates with poor prognosis of pancreatic ductal adenocarcinoma","volume":"40","author":"Wang","year":"2018","journal-title":"Oncol Rep"},{"key":"2025071701413285700_CIT0063","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1124\/pharmrev.121.000349","article-title":"Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology","volume":"74","author":"de Almeida","year":"2022","journal-title":"Pharmacol Rev"},{"key":"2025071701413285700_CIT0064","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.celrep.2015.06.059","article-title":"CXCR4 regulates extra-medullary myeloma through epithelial-mesenchymal-transition-like transcriptional activation","volume":"12","author":"Roccaro","year":"2015","journal-title":"Cell Rep"},{"key":"2025071701413285700_CIT0065","doi-asserted-by":"publisher","first-page":"109672","DOI":"10.1016\/j.cellsig.2020.109672","article-title":"CXCR4\/MIF axis amplifies tumor growth and epithelial-mesenchymal interaction in non-small cell lung cancer","volume":"73","author":"J\u00e4ger","year":"2020","journal-title":"Cell Signal"},{"key":"2025071701413285700_CIT0066","doi-asserted-by":"publisher","first-page":"80358","DOI":"10.18632\/oncotarget.18673","article-title":"Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4\/AKT\/EMT pathway in human glioblastoma cells","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"key":"2025071701413285700_CIT0067","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/bjh.16881","article-title":"Lenalidomide and pomalidomide potently interfere with induction of myeloid-derived suppressor cells in multiple myeloma","volume":"191","author":"Kuwahara-Ota","year":"2020","journal-title":"Br J Haematol"},{"key":"2025071701413285700_CIT0068","doi-asserted-by":"publisher","first-page":"4255","DOI":"10.1182\/blood-2022-166274","article-title":"Single-cell analyses of immune microenvironment informs potential benefits of dual macrophage-targeted therapy in multiple myeloma","volume":"140","author":"Li","year":"2022","journal-title":"Blood"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/carcin\/advance-article-pdf\/doi\/10.1093\/carcin\/bgaf033\/63705617\/bgaf033.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/46\/2\/bgaf033\/63705617\/bgaf033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/46\/2\/bgaf033\/63705617\/bgaf033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:41:39Z","timestamp":1752730899000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article\/doi\/10.1093\/carcin\/bgaf033\/8193990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4,3]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgaf033","relation":{},"ISSN":["0143-3334","1460-2180"],"issn-type":[{"value":"0143-3334","type":"print"},{"value":"1460-2180","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2025,2]]},"article-number":"bgaf033"}}