{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T07:30:31Z","timestamp":1764660631423,"version":"3.46.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Science Fund for Excellent Young Scholars","doi-asserted-by":"publisher","award":["82422067"],"award-info":[{"award-number":["82422067"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2024ZD0520102"],"award-info":[{"award-number":["2024ZD0520102"]}]},{"DOI":"10.13039\/501100010035","name":"Outstanding Youth Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230005"],"award-info":[{"award-number":["BK20230005"]}],"id":[{"id":"10.13039\/501100010035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>No studies have examined the association between non-malignant hematologic diseases and the risk of various cancers. To examine the associations between non-malignant hematologic diseases and cancer risk, we performed a cohort study and Mendelian randomization analysis. The association between hematologic diseases and incident cancer risk was assessed using time-varying Cox proportional hazards regression with multivariable hazard ratios (HRs) and 95% confidence intervals (CIs). Over a total of 5 031 372 person-years of follow-up in the UK Biobank, 32 589 (6.8%) patients were diagnosed with hematologic diseases, with 2279 incident cancer cases. Multivariable time-varying Cox regression models revealed that any hematologic disease was positively associated with total cancer (HR = 1.19; 95% CI, 1.14\u20131.24), hematologic cancer (HR = 1.92; 95% CI, 1.69\u20132.17), and digestive system cancer risks (HR = 1.36; 95% CI, 1.25\u20131.48). Nine hematologic diseases were associated with higher hematologic cancer risk, and six of the hematologic diseases were also associated with higher risks of four types of digestive system cancer (liver, stomach, esophageal, and small intestine cancers). Mendelian randomization analysis supported the positive association of agranulocytosis with leukemia, coagulation defects and spleen diseases with lymphoma, and unspecified anemia with small intestine cancer. This study indicates that non-malignant hematologic diseases are associated with an increased risk of cancer, particularly cancers in the hematological and digestive systems.<\/jats:p>","DOI":"10.1093\/carcin\/bgaf085","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T12:54:55Z","timestamp":1763470495000},"source":"Crossref","is-referenced-by-count":0,"title":["Non-malignant hematologic conditions and subsequent cancer risk: a prospective cohort study and Mendelian randomization analysis"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5380-7075","authenticated-orcid":false,"given":"Weiwei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University , Nanjing 211166 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4799-4220","authenticated-orcid":false,"given":"Jiacong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University , Nanjing 211166 ,","place":["China"]},{"name":"Department of Infection Management, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Second People's Hospital , Changzhou 213003 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1739-4358","authenticated-orcid":false,"given":"Hengyu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University , Nanjing 211166 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6454-4414","authenticated-orcid":false,"given":"Lijuan","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University , Nanjing 211166 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2599-9561","authenticated-orcid":false,"given":"Yuefan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University , Nanjing 211166 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9577-2132","authenticated-orcid":false,"given":"Xueni","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University , Nanjing 211166 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-7857","authenticated-orcid":false,"given":"Lu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University , Nanjing 211166 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-8192","authenticated-orcid":false,"given":"Qingyuan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University , Nanjing 211166 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4706-6093","authenticated-orcid":false,"given":"Mingming","family":"He","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Guangzhou 510060 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-0316","authenticated-orcid":false,"given":"Mingyang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. 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