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Integrated analysis of Genotype-Tissue Expression and The Cancer Genome Atlas databases revealed tumor-specific NNMT mRNA upregulation in these malignancies. Subsequently, the relationship between NNMT mRNA expression levels and clinical parameters across multiple cancer types was examined, with particular emphasis on LUAD, BC, and CRC. Single-cell RNA sequencing data further revealed elevated NNMT expression specifically within stromal compartments, with fibroblasts exhibiting the highest NNMT expression levels among stromal cell populations. Protein-level validation using the Human Protein Atlas database, the National Cancer Institute's Proteomics Data Commons, and the quantitative immunohistochemistry of our independent clinical cohorts demonstrated elevated stromal NNMT protein expression, particularly in cancer-associated fibroblasts. Cox regression analysis and survival curve analysis established stromal NNMT expression as an independent prognostic factor for overall survival in LUAD and BC patients (P &amp;lt; .05). In conclusion, high stromal NNMT levels correlated with poor prognosis, establishing it as a promising biomarker for risk stratification in LUAD and BC.<\/jats:p>","DOI":"10.1093\/carcin\/bgag020","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:44:58Z","timestamp":1774442698000},"source":"Crossref","is-referenced-by-count":1,"title":["Stromal NNMT overexpression as an independent prognostic biomarker in lung adenocarcinoma and breast carcinoma"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-3762","authenticated-orcid":false,"given":"Yanzhong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang 310016 ,","place":["China"]},{"name":"Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Zhejiang Provincial Department of Science and Technology , Hangzhou, Zhejiang 310016 ,","place":["China"]},{"name":"Zhejiang Engineering Research Center for Intelligent Manufacturing of Clinical Diagnostic Equipment, Zhejiang Provincial Department of Science and Technology , Hangzhou, Zhejiang 310016 ,","place":["China"]},{"name":"School of Medicine, Shaoxing University , Shaoxing, Zhejiang 312000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Zhuji Second People\u2019s Hospital , Zhuji, Zhejiang 311811 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang 310016 ,","place":["China"]},{"name":"School of Medicine, Shaoxing University , Shaoxing, Zhejiang 312000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang 310016 ,","place":["China"]},{"name":"Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Zhejiang Provincial Department of Science and Technology , Hangzhou, Zhejiang 310016 ,","place":["China"]},{"name":"Zhejiang Engineering Research Center for Intelligent Manufacturing of Clinical Diagnostic Equipment, Zhejiang Provincial Department of Science and Technology , Hangzhou, Zhejiang 310016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingtong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang 310016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7485-5237","authenticated-orcid":false,"given":"Yuzhen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang 310016 ,","place":["China"]},{"name":"Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Zhejiang Provincial Department of Science and Technology , Hangzhou, Zhejiang 310016 ,","place":["China"]},{"name":"Zhejiang Engineering Research Center for Intelligent Manufacturing of Clinical Diagnostic Equipment, Zhejiang Provincial Department of Science and Technology , Hangzhou, Zhejiang 310016 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuduo","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang 310016 ,","place":["P.R. 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