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Accumulating evidence demonstrates that CDC20 functions as an oncogenic factor, with its overexpression observed in various malignancies. Its dysregulation is closely associated with tumor initiation, progression, drug resistance, and poor clinical outcomes, underscoring its potential as a therapeutic target in anti-cancer strategies. In this review, we describe the biological functions of CDC20 in cancers, discuss its role and underlying mechanisms in solid tumors and hematological malignancies, and elucidate currently reported CDC20-targeted inhibitors along with their clinical benefits and challenges. By emphasizing the oncogenic significance of CDC20, we propose that the development of specific, safe, and potent CDC20 inhibitors could provide a promising therapeutic approach for cancer patients exhibiting CDC20 overexpression.<\/jats:p>","DOI":"10.1093\/carcin\/bgag021","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:47:20Z","timestamp":1774442840000},"source":"Crossref","is-referenced-by-count":1,"title":["Current progress of CDC20 in cancer development and targeting CDC20 for cancer therapy"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5708-9348","authenticated-orcid":false,"given":"Yingtong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology, Lymphoma Research Center, Peking University Third Hospital , 49 Huayuan North Road, Haidian District, Beijing 100191 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