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With sublethal activation, a phenomenon known as an \u201cincomplete or minority MOMP (mMOMP)\u201d occurs in which the cell survives the damage, enabling retention and propagation of somatic mutations. We tested whether prolonged asbestos fiber exposure drives mMOMP in the mesothelial cells, MeT-5A. After culturing the cells for 6\u202fmonths with chrysotile asbestos fibers or crocidolite asbestos fibers, we observed an increase in clonogenicity, migration, and invasion, suggesting that transformation to a malignant-like phenotype was occurring. Next, we found increases in reactive oxygen species (ROS) production, cyt c release, and \u03b3H2AX phosphorylation without activation of caspase-3 and apoptotic induction. These cellular features are consistent with mMOMP. Additionally, an anti-apoptotic, mitochondrial protein, myeloid cell leukemia-1 was upregulated by asbestos and enabled mMOMP by preventing MOMP. Furthermore, we observed that asbestos-induced mMOMP was associated with features of drug-tolerant persister cells. mMOMP facilitates avoidance of apoptosis by mesothelial cells while acquiring malignant traits. Our study indicates that mMOMP is a mechanism that promotes carcinogenesis, mitochondrial changes, and metabolic reprogramming. These findings offer a foundation for future therapeutic investigations.<\/jats:p>","DOI":"10.1093\/carcin\/bgag030","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:09:03Z","timestamp":1778760543000},"source":"Crossref","is-referenced-by-count":1,"title":["Asbestos exposure induces malignant-like phenotypes via minority MOMP and displays characteristics of drug-tolerant persister cells"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0257-1223","authenticated-orcid":false,"given":"Jaylon","family":"Aggison","sequence":"first","affiliation":[{"name":"David J. 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