{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:24:22Z","timestamp":1786112662518,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273028"],"award-info":[{"award-number":["82273028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372984"],"award-info":[{"award-number":["82372984"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573033"],"award-info":[{"award-number":["82573033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Oriental Talents","award":["National Administration of Traditional Chinese Medicine"],"award-info":[{"award-number":["National Administration of Traditional Chinese Medicine"]}]},{"name":"Shanghai Oriental Talents","award":["ZYYZDXK-2023063"],"award-info":[{"award-number":["ZYYZDXK-2023063"]}]},{"name":"National Program for the Construction of Advantageous Traditional Chinese Medicine Specialty","award":["XH40202-20250904"],"award-info":[{"award-number":["XH40202-20250904"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21ZR1482200"],"award-info":[{"award-number":["21ZR1482200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["21QA1408900"],"award-info":[{"award-number":["21QA1408900"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>SCF (Skp1-Cullin1-Fbox protein) is a multi-subunit RING-type E3 ligase and plays critical roles in various pivotal physiological and pathological processes by mediating the ubiquitination and degradation of key proteins. F-box proteins directly bind substrates, thereby determining their specificity, stability, and function. However, the regulatory mechanisms of FBXO21 degradation in human cancers remain largely elusive. In this study, we demonstrated that Neddylation-ROC1 E3 ligase regulates the protein level of FBXO21. Mechanistic studies revealed that Neddylation-ROC1 targeted FBXO21 for ubiquitination and degradation. Moreover, we found that FBXO21 depletion increased p53 protein stability by delaying its degradation, followed by increasing the transcriptional level of p21. Taken together, our \ufb01ndings reveal a previously unrecognized mechanism by which FBXO21 is regulated by Neddylation modification and regulates the p53-p21 signaling pathway.<\/jats:p>","DOI":"10.1093\/carcin\/bgag039","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:21:41Z","timestamp":1781612501000},"source":"Crossref","is-referenced-by-count":0,"title":["Neddylation pathway promotes the ubiquitinated degradation of FBXO21 in lung cancer cells"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7402-3742","authenticated-orcid":false,"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2771-523X","authenticated-orcid":false,"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2910-6764","authenticated-orcid":false,"given":"Tiangeng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Zhongshan Hospital, Fudan University , Shanghai 200071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7146-7771","authenticated-orcid":false,"given":"Yunyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5912-1307","authenticated-orcid":false,"given":"Wenjuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center, Fudan University , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9826-562X","authenticated-orcid":false,"given":"Gaili","family":"Chang","sequence":"additional","affiliation":[{"name":"Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine , Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6067-3923","authenticated-orcid":false,"given":"Mingsong","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University , Shanghai 200023 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9902-8246","authenticated-orcid":false,"given":"Lijun","family":"Jia","sequence":"additional","affiliation":[{"name":"Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine , Shanghai 200032 ,","place":["China"]},{"name":"School of Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6927-1448","authenticated-orcid":false,"given":"Lihui","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine , Shanghai 200032 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