{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:27:12Z","timestamp":1786724832831,"version":"build-2736575974"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":215,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Androgen receptor splice variant 7 (AR-V7) is associated with resistance to androgen receptor-targeting therapies in prostate cancer, but its prevalence and clinical relevance in non-prostatic cancers remain incompletely characterized. A systematic review was conducted in accordance with PRISMA guidelines. Thirty-four studies, including 4855 clinical cases and 60 cell lines, were included. Overall, AR-V7 positivity was reported in 948\/4855 clinical cases (19.5%); however, this represents a descriptive estimate across heterogeneous tumor types, study designs, and detection methods. Breast cancer accounted for 4057 of 4855 clinical cases (83.6%) and 815 of 948 AR-V7-positive cases (86.0%), with a within-cancer prevalence of 20.1%. However, after excluding the TCGA cohort in which AR-V7 was inferred through splice-junction analysis, the prevalence of AR-V7-positive breast cancer decreased to 9%. Higher tumor-specific proportions were observed in salivary duct carcinoma (55.2%), hepatocellular carcinoma (57.1%), and non-muscle-invasive bladder cancer (82.6%), but these estimates were based on smaller cohorts and should be interpreted cautiously. AR-V7 was present in several treatment-naive non-prostatic cancers, suggesting that it may represent a preexisting molecular feature in selected contexts. Current evidence suggests that AR-V7 warrants further investigation as a candidate biomarker. Standardized detection methods and prospective studies are needed before its clinical utility can be established.<\/jats:p>","DOI":"10.1093\/carcin\/bgag052","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:41:58Z","timestamp":1785498118000},"source":"Crossref","is-referenced-by-count":0,"title":["The prevalence of the\n                    <i>AR-V7<\/i>\n                    variant and its association with clinicopathologic characteristics in non-prostatic cancers\u2014a systematic review"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5660-8494","authenticated-orcid":false,"given":"Zaineh","family":"Alnoubani","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University , PO Box 2713, 2713 Doha ,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9161-5527","authenticated-orcid":false,"given":"Youssuf","family":"Khanafer","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University , PO Box 2713, 2713 Doha ,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2210-003X","authenticated-orcid":false,"given":"Adnan","family":"Fojnica","sequence":"additional","affiliation":[{"name":"Institute of Virology, TUM School of Medicine, Technical University of Munich , Trogerstra\u00dfe 30, 81675 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-8911","authenticated-orcid":false,"given":"Emir","family":"Begagic","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Cantonal Hospital Zenica , Crkvice 67, 72000 Zenica ,","place":["Bosnia and Herzegovina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7447-8007","authenticated-orcid":false,"given":"Inga","family":"Rose","sequence":"additional","affiliation":[{"name":"Reference Medicine , 4050 E Cotton Center Blvd Bldg 3 Suite 38, 85040 Phoenix, AZ ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0747-4431","authenticated-orcid":false,"given":"Zoran","family":"Gatalica","sequence":"additional","affiliation":[{"name":"Reference Medicine , 4050 E Cotton Center Blvd Bldg 3 Suite 38, 85040 Phoenix, AZ ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9743-7265","authenticated-orcid":false,"given":"Semir","family":"Vranic","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University , PO Box 2713, 2713 Doha ,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"2026081411020694600_bgag052-B1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1095\/biolreprod.113.109132","article-title":"Androgen receptor (AR) physiological roles in male and female reproductive systems: lessons learned from AR-knockout mice lacking AR in selective cells","volume":"89","author":"Chang","year":"2013","journal-title":"Biol Reprod"},{"key":"2026081411020694600_bgag052-B2","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1093\/humupd\/dmq003","article-title":"Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models","volume":"16","author":"Walters","year":"2010","journal-title":"Hum Reprod Update"},{"key":"2026081411020694600_bgag052-B3","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122653","article-title":"Androgen receptor signaling pathway in prostate cancer: from genetics to clinical applications","volume":"9","author":"Aurilio","year":"2020","journal-title":"Cells"},{"key":"2026081411020694600_bgag052-B4","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1111\/j.1742-1241.2011.02799.x","article-title":"Characterising the castration-resistant prostate cancer population: a systematic review","volume":"65","author":"Kirby","year":"2011","journal-title":"Int J Clin Pract"},{"key":"2026081411020694600_bgag052-B5","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11010257","article-title":"Biomarkers of castrate resistance in prostate cancer: androgen receptor amplification and T877A mutation detection by Multiplex droplet digital PCR","volume":"11","author":"Young","year":"2022","journal-title":"J Clin Med"},{"key":"2026081411020694600_bgag052-B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019059","article-title":"Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival","volume":"6","author":"H\u00f6rnberg","year":"2011","journal-title":"PLoS One"},{"key":"2026081411020694600_bgag052-B7","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1056\/NEJMoa1315815","article-title":"AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer","volume":"371","author":"Antonarakis","year":"2014","journal-title":"N Engl J Med"},{"key":"2026081411020694600_bgag052-B8","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1001\/jamaoncol.2015.1341","article-title":"Androgen receptor splice variant 7 and efficacy of taxane chemotherapy in patients with metastatic castration-resistant prostate cancer","volume":"1","author":"Antonarakis","year":"2015","journal-title":"JAMA Oncol"},{"key":"2026081411020694600_bgag052-B9","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/bju.14869","article-title":"Androgen receptor splice variant 7 (AR-V7) and AR full-length (AR-FL) as predictive biomarkers of therapeutic resistance: partners in crime?","volume":"124","author":"Barbier","year":"2019","journal-title":"BJU Int"},{"key":"2026081411020694600_bgag052-B10","doi-asserted-by":"publisher","first-page":"5469","DOI":"10.1158\/0008-5472.Can-08-0594","article-title":"Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance","volume":"68","author":"Dehm","year":"2008","journal-title":"Cancer Res"},{"key":"2026081411020694600_bgag052-B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2025.116050","article-title":"International expert consensus on the clinical integration of circulating tumor cells in solid tumors","volume":"231","author":"Nicol\u00f2","year":"2025","journal-title":"Eur J Cancer"},{"key":"2026081411020694600_bgag052-B12","doi-asserted-by":"publisher","first-page":"44728","DOI":"10.18632\/oncotarget.6296","article-title":"Expression of androgen receptor splice variants in clinical breast cancers","volume":"6","author":"Hickey","year":"2015","journal-title":"Oncotarget"},{"key":"2026081411020694600_bgag052-B13","doi-asserted-by":"publisher","first-page":"7322","DOI":"10.1002\/cam4.2602","article-title":"Novel therapeutic targets in salivary duct carcinoma uncovered by comprehensive molecular profiling","volume":"8","author":"Gargano","year":"2019","journal-title":"Cancer Med"},{"key":"2026081411020694600_bgag052-B14","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.11124\/jbisrir-d-19-00099","article-title":"Methodological quality of case series studies: an introduction to the JBI critical appraisal tool","volume":"18","author":"Munn","year":"2020","journal-title":"JBI Evid Synth"},{"key":"2026081411020694600_bgag052-B15","doi-asserted-by":"publisher","first-page":"401","DOI":"10.11124\/jbies-24-00523","article-title":"The revised JBI critical appraisal tool for the assessment of risk of bias for analytical cross-sectional studies","volume":"24","author":"Barker","year":"2026","journal-title":"JBI Evid Synth"},{"key":"2026081411020694600_bgag052-B16","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"Rob 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"Br Med J"},{"key":"2026081411020694600_bgag052-B17","doi-asserted-by":"publisher","first-page":"30","DOI":"10.14573\/altex.2111011","article-title":"Guidance document on good cell and tissue culture practice 2.0 (GCCP 2.0)","volume":"39","author":"Pamies","year":"2022","journal-title":"Altex"},{"key":"2026081411020694600_bgag052-B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002476","article-title":"Standards for cell line authentication and beyond","volume":"14","author":"Almeida","year":"2016","journal-title":"PLoS Biol"},{"key":"2026081411020694600_bgag052-B19","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s12672-014-0171-4","article-title":"Identification of androgen receptor splice variant transcripts in breast cancer cell lines and human tissues","volume":"5","author":"Hu","year":"2014","journal-title":"Horm Cancer"},{"key":"2026081411020694600_bgag052-B20","doi-asserted-by":"publisher","first-page":"6570","DOI":"10.1158\/1078-0432.Ccr-14-1746","article-title":"Alterations associated with androgen receptor gene activation in salivary duct carcinoma of both sexes: potential therapeutic ramifications","volume":"20","author":"Mitani","year":"2014","journal-title":"Clin Cancer Res"},{"key":"2026081411020694600_bgag052-B21","doi-asserted-by":"publisher","first-page":"3939","DOI":"10.1158\/1538-7445.Am2016-3939","article-title":"Abstract 3939: clinical significance of expression of androgen-receptor splice variant-7 (AR-V7) in neoadjuvant chemotherapy for breast cancer","volume":"76","author":"Asano","year":"2016","journal-title":"Cancer Res"},{"key":"2026081411020694600_bgag052-B22","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.1158\/1078-0432.Ccr-16-0637","article-title":"Comprehensive molecular characterization of salivary duct carcinoma reveals actionable targets and similarity to apocrine breast cancer","volume":"22","author":"Dalin","year":"2016","journal-title":"Clin Cancer Res"},{"key":"2026081411020694600_bgag052-B23","doi-asserted-by":"publisher","first-page":"P3-05-08","DOI":"10.1158\/1538-7445.Sabcs15-p3-05-08","article-title":"Abstract P3-05-08: high prevalence of splicing variant AR-V7 in triple negative breast carcinoma","volume":"76","author":"Singh","year":"2016","journal-title":"Cancer Res"},{"key":"2026081411020694600_bgag052-B24","doi-asserted-by":"publisher","first-page":"16962","DOI":"10.18632\/oncotarget.7655","article-title":"High throughput microscopy identifies bisphenol AP, a bisphenol A analog, as a novel AR down-regulator","volume":"7","author":"Stossi","year":"2016","journal-title":"Oncotarget"},{"key":"2026081411020694600_bgag052-B25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.oraloncology.2017.04.007","article-title":"Establishment and genomic characterization of primary salivary duct carcinoma cell line","volume":"69","author":"Li","year":"2017","journal-title":"Oral Oncol"},{"key":"2026081411020694600_bgag052-B26","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1158\/1541-7786.Mcr-17-0480","article-title":"AR expression in breast cancer CTCs associates with bone metastases","volume":"16","author":"Aceto","year":"2018","journal-title":"Mol Cancer Res"},{"key":"2026081411020694600_bgag052-B27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19071879","article-title":"Ethanolic extracts from Azadirachta indica leaves modulate transcriptional levels of hormone receptor variant in breast cancer cell lines","volume":"19","author":"Braga","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2026081411020694600_bgag052-B28","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1093\/annonc\/mdy141","article-title":"Tailoring treatment of salivary duct carcinoma (SDC) by liquid biopsy: ARv7 expression in circulating tumor cells","volume":"29","author":"Cappelletti","year":"2018","journal-title":"Ann Oncol"},{"key":"2026081411020694600_bgag052-B29","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.oraloncology.2018.06.026","article-title":"Detection of AR-V7 transcript with RNA in situ hybridization in human salivary duct cancer","volume":"84","author":"Kang","year":"2018","journal-title":"Oral Oncol"},{"key":"2026081411020694600_bgag052-B30","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.humpath.2018.09.009","article-title":"Expression pattern of androgen receptor and AR-V7 in androgen-deprivation therapy-na\u00efve salivary duct carcinomas","volume":"84","author":"Yang","year":"2019","journal-title":"Hum Pathol"},{"key":"2026081411020694600_bgag052-B31","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1158\/0008-5472.Can-19-1117","article-title":"Transcriptionally active androgen receptor splice variants promote hepatocellular carcinoma progression","volume":"80","author":"Dauki","year":"2020","journal-title":"Cancer Res"},{"key":"2026081411020694600_bgag052-B32","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1002\/cam4.2820","article-title":"Comparison of the biomarkers for targeted therapies in primary extra-mammary and mammary Paget's disease","volume":"9","author":"Gatalica","year":"2020","journal-title":"Cancer Med"},{"key":"2026081411020694600_bgag052-B33","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01658","article-title":"Circulating tumor cells expressing the prostate specific membrane antigen (PSMA) indicate worse outcome in primary, non-metastatic triple-negative breast cancer","volume":"10","author":"Kasimir-Bauer","year":"2020","journal-title":"Front Oncol"},{"key":"2026081411020694600_bgag052-B34","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1158\/1078-0432.Ccr-19-2170","article-title":"TBCRC 032 IB\/II multicenter study: molecular insights to AR antagonist and PI3K inhibitor efficacy in patients with AR(+) metastatic triple-negative breast cancer","volume":"26","author":"Lehmann","year":"2020","journal-title":"Clin Cancer Res"},{"key":"2026081411020694600_bgag052-B35","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.1111\/cas.14595","article-title":"Splicing factor PRPF6 upregulates oncogenic androgen receptor signaling pathway in hepatocellular carcinoma","volume":"111","author":"Song","year":"2020","journal-title":"Cancer Sci"},{"key":"2026081411020694600_bgag052-B36","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1002\/ijc.32795","article-title":"Prediction of clinical benefit from androgen deprivation therapy in salivary duct carcinoma patients","volume":"146","author":"van Boxtel","year":"2020","journal-title":"Int J Cancer"},{"key":"2026081411020694600_bgag052-B37","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.clgc.2021.02.002","article-title":"TERT gene fusions characterize a subset of metastatic Leydig cell tumors","volume":"19","author":"Kruslin","year":"2021","journal-title":"Clin Genitourin Cancer"},{"key":"2026081411020694600_bgag052-B38","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1002\/hed.26587","article-title":"The tumor immune contexture of salivary duct carcinoma","volume":"43","author":"Schvartsman","year":"2021","journal-title":"Head Neck"},{"key":"2026081411020694600_bgag052-B39","doi-asserted-by":"publisher","first-page":"S157","DOI":"10.1016\/S0090-8258(21)00941-0","article-title":"Expression of androgen receptor splice variant, AR-V7, in high-grade serous ovarian cancer","volume":"162","author":"Wilson","year":"2021","journal-title":"Gynecol Oncol"},{"key":"2026081411020694600_bgag052-B40","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41379-021-00924-5","article-title":"Androgen receptor splice variant-7 in breast cancer: clinical and pathologic correlations","volume":"35","author":"Ferguson","year":"2022","journal-title":"Mod Pathol"},{"key":"2026081411020694600_bgag052-B41","doi-asserted-by":"publisher","first-page":"617","DOI":"10.22146\/ijp.7416","article-title":"The enzalutamide and EPI-001 modulate cell proliferation and metastasis markers in T47D by targeting AR\/ARV7","volume":"34","author":"Ali","year":"2023","journal-title":"Indones J Pharm"},{"key":"2026081411020694600_bgag052-B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113461","article-title":"Identification of a targetable JAK-STAT enriched androgen receptor and androgen receptor splice variant positive triple-negative breast cancer subtype","volume":"42","author":"Asemota","year":"2023","journal-title":"Cell Rep"},{"key":"2026081411020694600_bgag052-B43","doi-asserted-by":"publisher","first-page":"S160","DOI":"10.1016\/j.labinv.2024.100428","article-title":"Androgen receptor splice variant-7 is an early pathogenic event in breast carcinomas with apocrine differentiation","volume":"104","author":"Gatalica","year":"2024","journal-title":"Lab Invest"},{"key":"2026081411020694600_bgag052-B44","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/gtc.13105","article-title":"Analysis of the responsiveness to antiandrogens in multiple breast cancer cell lines","volume":"29","author":"Kuroiwa","year":"2024","journal-title":"Genes Cells"},{"key":"2026081411020694600_bgag052-B45","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00345-024-05166-z","article-title":"Evaluation of androgen receptor and androgen receptor splice-variant 7 in bladder cancer; a novel approach into an ancient topic","volume":"42","author":"Sar\u0131kaya","year":"2024","journal-title":"World J Urol"},{"key":"2026081411020694600_bgag052-B46","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1186\/s12885-024-13165-x","article-title":"Prognostic role of androgen receptor splice variant 7 (AR-V7) in the pathogenesis of breast cancer","volume":"24","author":"Srivastava","year":"2024","journal-title":"BMC Cancer"},{"key":"2026081411020694600_bgag052-B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2024.106636","article-title":"A study of the role of androgen receptor and androgen receptor variant 7 in TNBC patients and the effect of their targeting by enzalutamide and EPI-001 in MDA-MB-231","volume":"245","author":"Ali","year":"2025","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2026081411020694600_bgag052-B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.patter.2025.101174","article-title":"SplitFusion enables ultrasensitive gene fusion detection and reveals fusion variant-associated tumor heterogeneity","volume":"6","author":"Bian","year":"2025","journal-title":"Patterns (N Y)"},{"key":"2026081411020694600_bgag052-B49","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1097\/pgp.0000000000001029","article-title":"Novel androgen receptor splice variant 7 in gynecologic tumors","volume":"44","author":"Wang","year":"2025","journal-title":"Int J Gynecol Pathol"},{"key":"2026081411020694600_bgag052-B50","first-page":"e238","article-title":"Uncovering AR-v7 as a common early event in apocrine breast tumors: rethinking antiandrogen therapy strategies","volume":"149","author":"Gatalica","year":"2025","journal-title":"Arch Pathol Lab Med"},{"key":"2026081411020694600_bgag052-B51","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1172\/jci122819","article-title":"Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer","volume":"129","author":"Sharp","year":"2019","journal-title":"J Clin Invest"},{"key":"2026081411020694600_bgag052-B52","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41698-025-01201-3","article-title":"Androgen receptor splice variant expression and prostate cancer recurrence after salvage therapy","volume":"10","author":"Konieczkowski","year":"2025","journal-title":"NPJ Precis Oncol"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/carcin\/advance-article-pdf\/doi\/10.1093\/carcin\/bgag052\/70475917\/bgag052.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/47\/3\/bgag052\/70475917\/bgag052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/47\/3\/bgag052\/70475917\/bgag052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:28:39Z","timestamp":1786721319000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article\/doi\/10.1093\/carcin\/bgag052\/8750766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7,7]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgag052","relation":{},"ISSN":["0143-3334","1460-2180"],"issn-type":[{"value":"0143-3334","type":"print"},{"value":"1460-2180","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"bgag052"}}