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Invest. , 108 , 649 \u2013654.","DOI":"10.1172\/JCI200113903"},{"key":"key\n\t\t\t\t20171011205858_B66","doi-asserted-by":"crossref","unstructured":"Xu,J., Zheng,S.L., Komiya,A. et al . ( 2002 ) Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Nature Genet. , 32 , 321 \u2013325.","DOI":"10.1038\/ng994"},{"key":"key\n\t\t\t\t20171011205858_B67","doi-asserted-by":"crossref","unstructured":"Ishiguro,T., Naito,M., Yamamoto,T., Hasegawa,G., Gejyo,F., Mitsuyama,M., Suzuki,H. and Kodama,T. ( 2001 ) Role of macrophage scavenger receptors in response to Listeria monocytogenes infection in mice. Am. J. Pathol. , 158 , 179 \u2013188.","DOI":"10.1016\/S0002-9440(10)63956-9"},{"key":"key\n\t\t\t\t20171011205858_B68","doi-asserted-by":"crossref","unstructured":"Wang,L., McDonnell,S.K., Cunningham,J.M., Hebbring,S., Jacobsen,S.J., Cerhan,J.R., Slager,S.L., Blute,M.L., Schaid,D.J. and Thibodeau,S.N. ( 2003 ) No association of germline alteration of MSR1 with prostate cancer risk. Nature Genet. , 35 , 128 \u2013129.","DOI":"10.1038\/ng1239"},{"key":"key\n\t\t\t\t20171011205858_B69","doi-asserted-by":"crossref","unstructured":"Xu,J., Zheng,S.L., Komiya,A. et al . ( 2003 ) Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Am. J. Hum. Genet. , 72 , 208 \u2013212.","DOI":"10.1086\/345802"},{"key":"key\n\t\t\t\t20171011205858_B70","doi-asserted-by":"crossref","unstructured":"Lindmark,F., Jonsson,B.A., Bergh,A., Stattin,P., Zheng,S.L., Meyers,D.A., Xu,J. and Gronberg,H. ( 2004 ) Analysis of the macrophage scavenger receptor 1 gene in Swedish hereditary and sporadic prostate cancer. Prostate , 59 , 132 \u2013140.","DOI":"10.1002\/pros.10367"},{"key":"key\n\t\t\t\t20171011205858_B71","doi-asserted-by":"crossref","unstructured":"Sorensen,M., Autrup,H., Tjonneland,A., Overvad,K. and Raaschou-Nielsen,O. 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Natl Acad. Sci. USA , 95 , 5275 \u20135280.","DOI":"10.1073\/pnas.95.9.5275"},{"key":"key\n\t\t\t\t20171011205858_B75","unstructured":"Brooks,J.D., Weinstein,M., Lin,X., Sun,Y., Pin,S.S., Bova,G.S., Epstein,J.I., Isaacs,W.B. and Nelson,W.G. ( 1998 ) CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia. Cancer Epidemiol. Biomarkers Prev. , 7 , 531 \u2013536."},{"key":"key\n\t\t\t\t20171011205858_B76","doi-asserted-by":"crossref","unstructured":"De Marzo,A.M., Marchi,V.L., Epstein,J.I. and Nelson,W.G. ( 1999 ) Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. Am. J. Pathol. , 155 , 1985 \u20131992.","DOI":"10.1016\/S0002-9440(10)65517-4"},{"key":"key\n\t\t\t\t20171011205858_B77","doi-asserted-by":"crossref","unstructured":"DeMarzo,A.M., Nelson,W.G., Isaacs,W.B. and Epstein,J.I. ( 2003 ) Pathological and molecular aspects of prostate cancer. Lancet , 361 , 955 \u2013964.","DOI":"10.1016\/S0140-6736(03)12779-1"},{"key":"key\n\t\t\t\t20171011205858_B78","unstructured":"Nelson,C.P., Kidd,L.C., Sauvageot,J., Isaacs,W.B., De Marzo,A.M., Groopman,J.D., Nelson,W.G. and Kensler,T.W. ( 2001 ) Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5- b ]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1. Cancer Res. , 61 , 103 \u2013109."},{"key":"key\n\t\t\t\t20171011205858_B79","unstructured":"Shirai,T., Sano,M., Tamano,S. et al . ( 1997 ) The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine (PhIP) derived from cooked foods. Cancer Res. , 57 , 195 \u2013198."},{"key":"key\n\t\t\t\t20171011205858_B80","unstructured":"Jeronimo,C., Varzim,G., Henrique,R., Oliveira,J., Bento,M.J., Silva,C., Lopes,C. and Sidransky,D. ( 2002 ) I105V polymorphism and promoter methylation of the GSTP1 gene in prostate adenocarcinoma. Cancer Epidemiol. Biomarkers Prev. , 11 , 445 \u2013450."},{"key":"key\n\t\t\t\t20171011205858_B81","doi-asserted-by":"crossref","unstructured":"Bieberich,C.J., Fujita,K., He,W.W. and Jay,G. ( 1996 ) Prostate-specific and androgen-dependent expression of a novel homeobox gene. J. Biol. Chem. , 271 , 31779 \u201331782.","DOI":"10.1074\/jbc.271.50.31779"},{"key":"key\n\t\t\t\t20171011205858_B82","doi-asserted-by":"crossref","unstructured":"Sciavolino,P.J., Abrams,E.W., Yang,L., Austenberg,L.P., Shen,M.M. and Abate-Shen,C. ( 1997 ) Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev. Dyn. , 209 , 127 \u2013138.","DOI":"10.1002\/(SICI)1097-0177(199705)209:1<127::AID-AJA12>3.0.CO;2-Z"},{"key":"key\n\t\t\t\t20171011205858_B83","unstructured":"Chen,H., Nandi,A.K., Li,X. and Bieberich,C.J. ( 2002 ) NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. Cancer Res. , 62 , 338 \u2013340."},{"key":"key\n\t\t\t\t20171011205858_B84","doi-asserted-by":"crossref","unstructured":"Kim,M.J., Cardiff,R.D., Desai,N., Banach-Petrosky,W.A., Parsons,R., Shen,M.M. and Abate-Shen,C. ( 2002 ) Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Proc. Natl Acad. Sci. USA , 99 , 2884 \u20132889.","DOI":"10.1073\/pnas.042688999"},{"key":"key\n\t\t\t\t20171011205858_B85","unstructured":"Emmert-Buck,M.R., Vocke,C.D., Pozzatti,R.O. et al . ( 1995 ) Allelic loss on chromosome 8p12\u201321 in microdissected prostatic intraepithelial neoplasia. Cancer Res. , 55 , 2959 \u20132962."},{"key":"key\n\t\t\t\t20171011205858_B86","doi-asserted-by":"crossref","unstructured":"Ornstein,D.K., Cinquanta,M., Weiler,S., Duray,P.H., Emmert-Buck,M.R., Vocke,C.D., Linehan,W.M. and Ferretti,J.A. ( 2001 ) Expression studies and mutational analysis of the androgen regulated homeobox gene NKX3.1 in benign and malignant prostate epithelium. J. Urol. , 165 , 1329 \u20131334.","DOI":"10.1016\/S0022-5347(01)69894-X"},{"key":"key\n\t\t\t\t20171011205858_B87","unstructured":"Voeller,H.J., Augustus,M., Madike,V., Bova,G.S., Carter,K.C. and Gelmann,E.P. ( 1997 ) Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers. Cancer Res. , 57 , 4455 \u20134459."},{"key":"key\n\t\t\t\t20171011205858_B88","unstructured":"Bowen,C., Bubendorf,L., Voeller,H.J. et al . ( 2000 ) Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression. Cancer Res. , 60 , 6111 \u20136115."},{"key":"key\n\t\t\t\t20171011205858_B89","doi-asserted-by":"crossref","unstructured":"Franks,L.M. ( 1954 ) Atrophy and hyperplasia in the prostate proper. J. Pathol. Bacteriol. , 68 , 617 \u2013621.","DOI":"10.1002\/path.1700680234"},{"key":"key\n\t\t\t\t20171011205858_B90","doi-asserted-by":"crossref","unstructured":"Rich,A.R. ( 1979 ) Classics in oncology. On the frequency of occurrence of occult carcinoma of the prostate: Arnold Rice Rich, M.D., Journal of Urology 33:3, 1935. CA Cancer J. Clin. , 29 , 115 \u2013119.","DOI":"10.3322\/canjclin.29.2.115"},{"key":"key\n\t\t\t\t20171011205858_B91","doi-asserted-by":"crossref","unstructured":"Ruska,K.M., Sauvageot,J. and Epstein,J.I. ( 1998 ) Histology and cellular kinetics of prostatic atrophy. Am. J. Surg. Pathol. , 22 , 1073 \u20131077.","DOI":"10.1097\/00000478-199809000-00005"},{"key":"key\n\t\t\t\t20171011205858_B92","doi-asserted-by":"crossref","unstructured":"Shah,R., Mucci,N.R., Amin,A., Macoska,J.A. and Rubin,M.A. ( 2001 ) Postatrophic hyperplasia of the prostate gland: neoplastic precursor or innocent bystander? Am. J. Pathol. , 158 , 1767 \u20131773.","DOI":"10.1016\/S0002-9440(10)64132-6"},{"key":"key\n\t\t\t\t20171011205858_B93","doi-asserted-by":"crossref","unstructured":"Putzi,M.J. and De Marzo,A.M. ( 2000 ) Morphologic transitions between proliferative inflammatory atrophy and high-grade prostatic intraepithelial neoplasia. Urology , 56 , 828 \u2013832.","DOI":"10.1016\/S0090-4295(00)00776-7"},{"key":"key\n\t\t\t\t20171011205858_B94","doi-asserted-by":"crossref","unstructured":"Nakayama,M., Bennett,C.J., Hicks,J.L., Epstein,J.I., Platz,E.A., Nelson,W.G. and De Marzo,A.M. ( 2003 ) Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection. Am. J. Pathol. , 163 , 923 \u2013933.","DOI":"10.1016\/S0002-9440(10)63452-9"},{"key":"key\n\t\t\t\t20171011205858_B95","doi-asserted-by":"crossref","unstructured":"Reznik,G., Hamlin,M.H.,II, Ward,J.M. and Stinson,S.F. ( 1981 ) Prostatic hyperplasia and neoplasia in aging F344 rats. 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Pathol. , 23 , 932 \u2013936.","DOI":"10.1097\/00000478-199908000-00011"},{"key":"key\n\t\t\t\t20171011205858_B102","doi-asserted-by":"crossref","unstructured":"Billis,A. and Magna,L.A. ( 2003 ) Inflammatory atrophy of the prostate. Prevalence and significance. Arch. Pathol. Lab. Med. , 127 , 840 \u2013844.","DOI":"10.5858\/2003-127-840-IAOTP"},{"key":"key\n\t\t\t\t20171011205858_B103","doi-asserted-by":"crossref","unstructured":"Montironi,R., Mazzucchelli,R. and Scarpelli,M. ( 2002 ) Precancerous lesions and conditions of the prostate: from morphological and biological characterization to chemoprevention. Ann. N. Y. Acad. Sci. , 963 , 169 \u2013184.","DOI":"10.1111\/j.1749-6632.2002.tb04108.x"},{"key":"key\n\t\t\t\t20171011205858_B104","unstructured":"Cheng,L., Shan,A., Cheville,J.C., Qian,J. and Bostwick,D.G. ( 1998 ) Atypical adenomatous hyperplasia of the prostate: a premalignant lesion? Cancer Res. , 58 , 389 \u2013391."},{"key":"key\n\t\t\t\t20171011205858_B105","doi-asserted-by":"crossref","unstructured":"Grignon,D.J. and Sakr,W.A. ( 1996 ) Atypical adenomatous hyperplasia of the prostate: a critical review. Eur. Urol. , 30 , 206 \u2013211.","DOI":"10.1159\/000474171"},{"key":"key\n\t\t\t\t20171011205858_B106","doi-asserted-by":"crossref","unstructured":"Beckman,J.S. and Koppenol,W.H. ( 1996 ) Nitric oxide, superoxide and peroxynitrite: the good, the bad and the ugly. Am. J. Physiol. , 271 , C1424 \u2013C1437.","DOI":"10.1152\/ajpcell.1996.271.5.C1424"},{"key":"key\n\t\t\t\t20171011205858_B107","doi-asserted-by":"crossref","unstructured":"Espey,M.G., Miranda,K.M., Thomas,D.D., Xavier,S., Citrin,D., Vitek,M.P. and Wink,D.A. ( 2002 ) A chemical perspective on the interplay between NO, reactive oxygen species and reactive nitrogen oxide species. Ann. N. Y. Acad. Sci. , 962 , 195 \u2013206.","DOI":"10.1111\/j.1749-6632.2002.tb04068.x"},{"key":"key\n\t\t\t\t20171011205858_B108","doi-asserted-by":"crossref","unstructured":"Ernst,P.B. and Gold,B.D. ( 2000 ) The disease spectrum of Helicobacter pylori : the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu. Rev. Microbiol. , 54 , 615 \u2013640.","DOI":"10.1146\/annurev.micro.54.1.615"},{"key":"key\n\t\t\t\t20171011205858_B109","doi-asserted-by":"crossref","unstructured":"Pervin,S., Singh,R. and Chaudhuri,G. ( 2001 ) Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1. Proc. Natl Acad. Sci. USA , 98 , 3583 \u20133588.","DOI":"10.1073\/pnas.041603998"},{"key":"key\n\t\t\t\t20171011205858_B110","doi-asserted-by":"crossref","unstructured":"Melino,G., Bernassola,F., Knight,R.A., Corasaniti,M.T., Nistico,G. and Finazzi-Agro,A. ( 1997 ) S-nitrosylation regulates apoptosis. 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Health Perspect. , 106 (suppl. 5), 1229 \u20131234.","DOI":"10.1289\/ehp.98106s51229"},{"key":"key\n\t\t\t\t20171011205858_B114","doi-asserted-by":"crossref","unstructured":"Hussain,T., Gupta,S. and Mukhtar,H. ( 2003 ) Cyclooxygenase-2 and prostate carcinogenesis. Cancer Lett. , 191 , 125 \u2013135.","DOI":"10.1016\/S0304-3835(02)00524-4"},{"key":"key\n\t\t\t\t20171011205858_B115","doi-asserted-by":"crossref","unstructured":"Yegnasubramanian,S., Kowalski,J., Gonzalgo,M.L. et al . ( 2004 ) Hypermethylation of CpG islands in primary and metastatic human prostate cancer. Cancer Res. , 64 , 1975 \u20131986.","DOI":"10.1158\/0008-5472.CAN-03-3972"},{"key":"key\n\t\t\t\t20171011205858_B116","doi-asserted-by":"crossref","unstructured":"Phillips,L.L. ( 1956 ) Effect of free radicals on chromosomes of barley. Science , 124 , 375 \u2013381.","DOI":"10.1126\/science.124.3227.889"},{"key":"key\n\t\t\t\t20171011205858_B117","doi-asserted-by":"crossref","unstructured":"Olinski,R., Gackowski,D., Foksinski,M., Rozalski,R., Roszkowski,K. and Jaruga,P. ( 2002 ) Oxidative DNA damage: assessment of the role in carcinogenesis, atherosclerosis and acquired immunodeficiency syndrome. Free Radic. Biol. Med. , 33 , 192 \u2013200.","DOI":"10.1016\/S0891-5849(02)00878-X"},{"key":"key\n\t\t\t\t20171011205858_B118","unstructured":"Goode,E.L., Ulrich,C.M. and Potter,J.D. ( 2002 ) Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol. Biomarkers Prev. , 11 , 1513 \u20131530."},{"key":"key\n\t\t\t\t20171011205858_B119","doi-asserted-by":"crossref","unstructured":"Lee,W.H., Morton,R.A., Epstein,J.I., Brooks,J.D., Campbell,P.A., Bova,G.S., Hsieh,W.S., Isaacs,W.B. and Nelson,W.G. ( 1994 ) Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis. Proc. Natl Acad. Sci. USA , 91 , 11733 \u201311737.","DOI":"10.1073\/pnas.91.24.11733"},{"key":"key\n\t\t\t\t20171011205858_B120","doi-asserted-by":"crossref","unstructured":"Heller,R., Polack,T., Grabner,R. and Till,U. ( 1999 ) Nitric oxide inhibits proliferation of human endothelial cells via a mechanism independent of cGMP. Atherosclerosis , 144 , 49 \u201357.","DOI":"10.1016\/S0021-9150(99)00041-6"},{"key":"key\n\t\t\t\t20171011205858_B121","doi-asserted-by":"crossref","unstructured":"Weller,R., Billiar,T. and Vodovotz,Y. ( 2002 ) Pro- and anti-apoptotic effects of nitric oxide in irradiated keratinocytes: the role of superoxide. Skin Pharmacol. Appl. Skin Physiol. , 15 , 348 \u2013352.","DOI":"10.1159\/000064540"},{"key":"key\n\t\t\t\t20171011205858_B122","doi-asserted-by":"crossref","unstructured":"Ohshima,H. and Bartsch,H. ( 1994 ) Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat. Res. , 305 , 253 \u2013264.","DOI":"10.1016\/0027-5107(94)90245-3"},{"key":"key\n\t\t\t\t20171011205858_B123","doi-asserted-by":"crossref","unstructured":"Roy-Burman,P., Wu,H., Powell,W.C., Hagenkord,J. and Cohen,M.B. ( 2004 ) Genetically defined mouse models that mimic natural aspects of human prostate cancer development. Endocr. Relat. Cancer , 11 , 225 \u2013254.","DOI":"10.1677\/erc.0.0110225"},{"key":"key\n\t\t\t\t20171011205858_B124","doi-asserted-by":"crossref","unstructured":"Shirai,T., Takahashi,S., Cui,L., Futakuchi,M., Kato,K., Tamano,S. and Imaida,K. ( 2000 ) Experimental prostate carcinogenesis\u2014rodent models. Mutat. Res. , 462 , 219 \u2013226.","DOI":"10.1016\/S1383-5742(00)00039-9"},{"key":"key\n\t\t\t\t20171011205858_B125","doi-asserted-by":"crossref","unstructured":"Muntzing,J., Sufrin,G. and Murphy,G.P. ( 1979 ) Prostatitis in the rat. Scand. J. Urol. Nephrol. , 13 , 17 \u201322.","DOI":"10.3109\/00365597909179995"},{"key":"key\n\t\t\t\t20171011205858_B126","doi-asserted-by":"crossref","unstructured":"Lundgren,R., Holmquist,B., Hesselvik,M. and Muntzing,J. ( 1984 ) Treatment of prostatitis in the rat. Prostate , 5 , 277 \u2013284.","DOI":"10.1002\/pros.2990050305"},{"key":"key\n\t\t\t\t20171011205858_B127","doi-asserted-by":"crossref","unstructured":"Keith,I.M., Jin,J., Neal,D.,Jr, Teunissen,B.D. and Moon,T.D. ( 2001 ) Cell relationship in a Wistar rat model of spontaneous prostatitis. J. Urol. , 166 , 323 \u2013328.","DOI":"10.1016\/S0022-5347(05)66153-8"},{"key":"key\n\t\t\t\t20171011205858_B128","doi-asserted-by":"crossref","unstructured":"Naslund,M.J., Strandberg,J.D. and Coffey,D.S. ( 1988 ) The role of androgens and estrogens in the pathogenesis of experimental nonbacterial prostatitis. J. 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( 1999 ) Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring. Toxicol. Sci. , 52 , 68 \u201379.","DOI":"10.1093\/toxsci\/52.1.68"},{"key":"key\n\t\t\t\t20171011205858_B134","unstructured":"Taguchi,O., Kojima,A. and Nishizuka,Y. ( 1985 ) Experimental autoimmune prostatitis after neonatal thymectomy in the mouse. Clin. Exp. Immunol. , 60 , 123 \u2013129."},{"key":"key\n\t\t\t\t20171011205858_B135","doi-asserted-by":"crossref","unstructured":"Bagavant,H., Thompson,C., Ohno,K., Setiady,Y. and Tung,K.S. ( 2002 ) Differential effect of neonatal thymectomy on systemic and organ-specific autoimmune disease. Int. Immunol. , 14 , 1397 \u20131406.","DOI":"10.1093\/intimm\/dxf105"},{"key":"key\n\t\t\t\t20171011205858_B136","doi-asserted-by":"crossref","unstructured":"Galmarini,M., Ferro,M.E. and Riera,C.M. ( 1988 ) Delayed hypersensitivity and lesions following isoimmunization with modified rat male accessory glands: kinetics of induction. J. Reprod. Immunol. , 13 , 147 \u2013157.","DOI":"10.1016\/0165-0378(88)90058-7"},{"key":"key\n\t\t\t\t20171011205858_B137","doi-asserted-by":"crossref","unstructured":"Keetch,D.W., Humphrey,P. and Ratliff,T.L. ( 1994 ) Development of a mouse model for nonbacterial prostatitis. J. Urol. , 152 , 247 \u2013250.","DOI":"10.1016\/S0022-5347(17)32871-9"},{"key":"key\n\t\t\t\t20171011205858_B138","doi-asserted-by":"crossref","unstructured":"Casas-Ingaramo,A., Depiante-Depaoli,M. and Pacheco-Rupil,B. ( 1991 ) Activation of cytotoxic cells by syngeneic prostate antigens in experimental autoimmune vesiculo-prostatitis. Autoimmunity , 9 , 151 \u2013157.","DOI":"10.3109\/08916939109006751"},{"key":"key\n\t\t\t\t20171011205858_B139","doi-asserted-by":"crossref","unstructured":"Orsilles,M.A. and Depiante-Depaoli,M. ( 1998 ) Oxidative stress-related parameters in prostate of rats with experimental autoimmune prostatitis. Prostate , 34 , 270 \u2013274.","DOI":"10.1002\/(SICI)1097-0045(19980301)34:4<270::AID-PROS4>3.0.CO;2-L"},{"key":"key\n\t\t\t\t20171011205858_B140","doi-asserted-by":"crossref","unstructured":"Damotte,D., Colomb,E., Cailleau,C., Brousse,N., Charreire,J. and Carnaud,C. ( 1997 ) Analysis of susceptibility of NOD mice to spontaneous and experimentally induced thyroiditis. Eur. J. Immunol. , 27 , 2854 \u20132862.","DOI":"10.1002\/eji.1830271117"},{"key":"key\n\t\t\t\t20171011205858_B141","doi-asserted-by":"crossref","unstructured":"Rivero,V.E., Cailleau,C., Depiante-Depaoli,M., Riera,C.M. and Carnaud,C. ( 1998 ) Non-obese diabetic (NOD) mice are genetically susceptible to experimental autoimmune prostatitis (EAP). J. Autoimmun. , 11 , 603 \u2013610.","DOI":"10.1006\/jaut.1998.0248"},{"key":"key\n\t\t\t\t20171011205858_B142","doi-asserted-by":"crossref","unstructured":"Rivero,V., Carnaud,C. and Riera,C.M. ( 2002 ) Prostatein or steroid binding protein (PSBP) induces experimental autoimmune prostatitis (EAP) in NOD mice. Clin. Immunol. , 105 , 176 \u2013184.","DOI":"10.1006\/clim.2002.5281"},{"key":"key\n\t\t\t\t20171011205858_B143","doi-asserted-by":"crossref","unstructured":"Nickel,J.C., Olson,M.E., Barabas,A., Benediktsson,H., Dasgupta,M.K. and Costerton,J.W. ( 1990 ) Pathogenesis of chronic bacterial prostatitis in an animal model. Br. J. Urol. , 66 , 47 \u201354.","DOI":"10.1111\/j.1464-410X.1990.tb14864.x"},{"key":"key\n\t\t\t\t20171011205858_B144","doi-asserted-by":"crossref","unstructured":"Rippere-Lampe,K.E., Lang,M., Ceri,H., Olson,M., Lockman,H.A. and O'Brien,A.D. ( 2001 ) Cytotoxic necrotizing factor type 1-positive Escherichia coli causes increased inflammation and tissue damage to the prostate in a rat prostatitis model. Infect. Immun. , 69 , 6515 \u20136519.","DOI":"10.1128\/IAI.69.10.6515-6519.2001"},{"key":"key\n\t\t\t\t20171011205858_B145","doi-asserted-by":"crossref","unstructured":"Jantos,C.A., Augustin,J., Durchfeld-Meyer,B., Baumgartner,W. and Schiefer,H.G. ( 1998 ) Experimental genital tract infection with Chlamydia psittaci (GPIC agent) in male rats. Infection , 26 , 126 \u2013130.","DOI":"10.1007\/BF02767776"},{"key":"key\n\t\t\t\t20171011205858_B146","doi-asserted-by":"crossref","unstructured":"Seo,S.I., Lee,S.J., Kim,J.C., Choi,Y.J., Sw,S.W., Hwang,T.K. and Cho,Y.H. ( 2003 ) Effects of androgen deprivation on chronic bacterial prostatitis in a rat model. Int. J. Urol. , 10 , 485 \u2013491.","DOI":"10.1046\/j.1442-2042.2003.00666.x"},{"key":"key\n\t\t\t\t20171011205858_B147","doi-asserted-by":"crossref","unstructured":"Lang,M.D., Nickel,J.C., Olson,M.E., Howard,S.R. and Ceri,H. ( 2000 ) Rat model of experimentally induced abacterial prostatitis. Prostate , 45 , 201 \u2013206.","DOI":"10.1002\/1097-0045(20001101)45:3<201::AID-PROS1>3.0.CO;2-Q"},{"key":"key\n\t\t\t\t20171011205858_B148","doi-asserted-by":"crossref","unstructured":"Kwon,S.M., Kim,S.I., Chun,D.C., Cho,N.H., Chung,B.C., Park,B.W. and Hong,S.J. ( 2001 ) Development of rat prostatitis model by oral administration of isoflavone and its characteristics. Yonsei Med. J. , 42 , 395 \u2013404.","DOI":"10.3349\/ymj.2001.42.4.395"},{"key":"key\n\t\t\t\t20171011205858_B149","unstructured":"Song,Z., Wu,X., Powell,W.C., Cardiff,R.D., Cohen,M.B., Tin,R.T., Matusik,R.J., Miller,G.J. and Roy-Burman,P. ( 2002 ) Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: a new mouse model for prostatic intraepithelial neoplasia. Cancer Res. , 62 , 5096 \u20135105."},{"key":"key\n\t\t\t\t20171011205858_B150","unstructured":"Hurwitz,A.A., Foster,B.A., Kwon,E.D., Truong,T., Choi,E.M., Greenberg,N.M., Burg,M.B. and Allison,J.P. ( 2000 ) Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res. , 60 , 2444 \u20132448."},{"key":"key\n\t\t\t\t20171011205858_B151","doi-asserted-by":"crossref","unstructured":"Thompson,C.B. and Allison,J.P. ( 1997 ) The emerging role of CTLA-4 as an immune attenuator. Immunity , 7 , 445 \u2013450.","DOI":"10.1016\/S1074-7613(00)80366-0"},{"key":"key\n\t\t\t\t20171011205858_B152","doi-asserted-by":"crossref","unstructured":"Leach,D.R., Krummel,M.F. and Allison,J.P. ( 1996 ) Enhancement of antitumor immunity by CTLA-4 blockade. 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