{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:47:12Z","timestamp":1792082832313,"version":"4.4.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"DOI":"10.1093\/carcin\/bgi088","type":"journal-article","created":{"date-parts":[[2005,4,8]],"date-time":"2005-04-08T00:23:57Z","timestamp":1112919837000},"page":"1422-1429","source":"Crossref","is-referenced-by-count":46,"title":["Associations between apoE genotype and colon and rectal cancer"],"prefix":"10.1093","volume":"26","author":[{"given":"Martha L.","family":"Slattery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Murtaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khe Ni","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore R.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade","family":"Samowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,4,7]]},"reference":[{"key":"key\n\t\t\t\t20171011210521_B1","doi-asserted-by":"crossref","unstructured":"Ganan,A., Corella,D., Guillen,M., Ordovas,J.M. and Pocovi,M. ( 2004 ) Frequencies of apolipoprotein A4 gene polymorphisms and association with serum lipid concentrations in two healthy Spanish populations. Hum. Biol. , 76 , 253 \u2013266.","DOI":"10.1353\/hub.2004.0031"},{"key":"key\n\t\t\t\t20171011210521_B2","doi-asserted-by":"crossref","unstructured":"Song,Y., Stampfer,M.J. and Liu,S. ( 2004 ) Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease. Ann. Intern. Med. , 141 , 137 \u2013147.","DOI":"10.7326\/0003-4819-141-2-200407200-00013"},{"key":"key\n\t\t\t\t20171011210521_B3","unstructured":"Sing,C.F. and Davignon,J. ( 1985 ) Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am. J. Hum. Genet. , 37 , 268 \u2013285."},{"key":"key\n\t\t\t\t20171011210521_B4","doi-asserted-by":"crossref","unstructured":"Stannard,A.K., Riddell,D.R., Sacre,S.M., Tagalakis,A.D., Langer,C., von Eckardstein,A., Cullen,P., Athanasopoulos,T., Dickson,G. and Owen,J.S. ( 2001 ) Cell-derived apolipoprotein E (apoE) particles inhibit vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells. J. Biol. Chem. , 276 , 46011 \u201346016.","DOI":"10.1074\/jbc.M104812200"},{"key":"key\n\t\t\t\t20171011210521_B5","doi-asserted-by":"crossref","unstructured":"Stannard,A.K., Riddell,D.R., Bradley,N.J., Hassall,D.G., Graham,A. and Owen,J.S. ( 1998 ) Apolipoprotein E and regulation of cytokine-induced cell adhesion molecule expression in endothelial cells. Atherosclerosis , 139 , 57 \u201364.","DOI":"10.1016\/S0021-9150(98)00052-5"},{"key":"key\n\t\t\t\t20171011210521_B6","doi-asserted-by":"crossref","unstructured":"Sacre,S.M., Stannard,A.K. and Owen,J.S. ( 2003 ) ApolipoproteinE (apoE) isoforms differentially induce nitric oxide production in endothelial cells. FEBS Lett. , 540 , 181 \u2013187.","DOI":"10.1016\/S0014-5793(03)00261-8"},{"key":"key\n\t\t\t\t20171011210521_B7","doi-asserted-by":"crossref","unstructured":"Vogel,T., Guo,N.H., Guy,R., Drezlich,N., Krutzsch,H.C., Blake,D.A., Panet,A. and Roberts,D.D. ( 1994 ) Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation. J. Cell. Biochem. , 54 , 299 \u2013308.","DOI":"10.1002\/jcb.240540306"},{"key":"key\n\t\t\t\t20171011210521_B8","doi-asserted-by":"crossref","unstructured":"Davignon,J., Gregg,R.E. and Sing,C.F. ( 1988 ) Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis , 8 , 1 \u201321.","DOI":"10.1161\/01.ATV.8.1.1"},{"key":"key\n\t\t\t\t20171011210521_B9","doi-asserted-by":"crossref","unstructured":"Xhignesse,M., Lussier-Cacan,S., Sing,C.F., Kessling,A.M. and Davignon,J. ( 1991 ) Influences of common variants of apolipoprotein E on measures of lipid metabolism in a sample selected for health. Arterioscler. Thromb. , 11 , 1100 \u20131110.","DOI":"10.1161\/01.ATV.11.4.1100"},{"key":"key\n\t\t\t\t20171011210521_B10","doi-asserted-by":"crossref","unstructured":"Niemi,M., Kervinen,K., Kiviniemi,H., Lukkarinen,O., Kyllonen,A.P., Apaja-Sarkkinen,M., Savolainen,M.J., Kairaluoma,M.I. and Kesaniemi,Y.A. ( 2000 ) Apolipoprotein E phenotype, cholesterol and breast and prostate cancer. J. Epidemiol. Community Health , 54 , 938 \u2013939.","DOI":"10.1136\/jech.54.12.938"},{"key":"key\n\t\t\t\t20171011210521_B11","doi-asserted-by":"crossref","unstructured":"Kervinen,K., Sodervik,H., Makela,J., Lehtola,J., Niemi,M., Kairaluoma,M.I. and Kesaniemi,Y.A. ( 1996 ) Is the development of adenoma and carcinoma in proximal colon related to apolipoprotein E phenotype? Gastroenterology , 110 , 1785 \u20131790.","DOI":"10.1053\/gast.1996.v110.pm8964404"},{"key":"key\n\t\t\t\t20171011210521_B12","doi-asserted-by":"crossref","unstructured":"Shinomiya,S., Sasaki,J., Kiyohara,C. et al . ( 2001 ) Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men. Cancer Lett. , 164 , 33 \u201340.","DOI":"10.1016\/S0304-3835(00)00724-2"},{"key":"key\n\t\t\t\t20171011210521_B13","doi-asserted-by":"crossref","unstructured":"Watson,M.A., Gay,L., Stebbings,W.S., Speakman,C.T., Bingham,S.A. and Loktionov,A. ( 2003 ) Apolipoprotein E gene polymorphism and colorectal cancer: gender-specific modulation of risk and prognosis. Clin. Sci. (Lond). , 104 , 537 \u2013545.","DOI":"10.1042\/CS20020329"},{"key":"key\n\t\t\t\t20171011210521_B14","doi-asserted-by":"crossref","unstructured":"Bertomeu,A., Ros,E., Zambon,D., Vela,M., Perez-Ayuso,R.M., Targarona,E., Trias,M., Sanllehy,C., Casals,E. and Ribo,J.M. ( 1996 ) Apolipoprotein E polymorphism and gallstones. Gastroenterology , 111 , 1603 \u20131610.","DOI":"10.1016\/S0016-5085(96)70023-9"},{"key":"key\n\t\t\t\t20171011210521_B15","doi-asserted-by":"crossref","unstructured":"Katan,M.B. ( 1986 ) Apolipoprotein E isoforms, serum cholesterol, and cancer. Lancet , 1 , 507 \u2013508.","DOI":"10.1016\/S0140-6736(86)92972-7"},{"key":"key\n\t\t\t\t20171011210521_B16","doi-asserted-by":"crossref","unstructured":"Juvonen,T., Kervinen,K., Kairaluoma,M.I., Lajunen,L.H. and Kesaniemi,Y.A. ( 1993 ) Gallstone cholesterol content is related to apolipoprotein E polymorphism. Gastroenterology , 104 , 1806 \u20131813.","DOI":"10.1016\/0016-5085(93)90662-V"},{"key":"key\n\t\t\t\t20171011210521_B17","doi-asserted-by":"crossref","unstructured":"Van Erpecum,K.J., Van Berge-henegouwen,G.P., Eckhardt,E.R., Portincasa,P., Van De Heijning,B.J., Dallinga-Thie,G.M. and Groen,A.K. ( 1998 ) Cholesterol crystallization in human gallbladder bile: relation to gallstone number, bile composition, and apolipoprotein E4 isoform. Hepatology , 27 , 1508 \u20131516.","DOI":"10.1002\/hep.510270607"},{"key":"key\n\t\t\t\t20171011210521_B18","doi-asserted-by":"crossref","unstructured":"Van Erpecum,K.J. and Carey,M.C. ( 1996 ) Apolipoprotein E4: another risk factor for cholesterol gallstone formation? Gastroenterology , 111 , 1764 \u20131767.","DOI":"10.1016\/S0016-5085(96)70044-6"},{"key":"key\n\t\t\t\t20171011210521_B19","unstructured":"Berkel,J., Hombergen,D.A., Hooymayers,I.E. and Faber,J.A. ( 1990 ) Cholecystectomy and colon cancer. Am. J. Gastroenterol. , 85 , 61 \u201364."},{"key":"key\n\t\t\t\t20171011210521_B20","doi-asserted-by":"crossref","unstructured":"Bach-Ngohou,K., Ouguerram,K., Nazih,H., Maugere,P., Ripolles-Piquer,B., Zair,Y., Frenais,R., Krempf,M. and Bard,J.M. ( 2002 ) Apolipoprotein E kinetics: influence of insulin resistance and type 2 diabetes. Int. J. Obes. Relat. Metab. Disord. , 26 , 1451 \u20131458.","DOI":"10.1038\/sj.ijo.0802149"},{"key":"key\n\t\t\t\t20171011210521_B21","doi-asserted-by":"crossref","unstructured":"Orchard,T.J., Eichner,J., Kuller,L.H., Becker,D.J., McCallum,L.M. and Grandits,G.A. ( 1994 ) Insulin as a predictor of coronary heart disease: interaction with apolipoprotein E phenotype. A report from the multiple risk factor intervention trial. Ann. Epidemiol. , 4 , 40 \u201345.","DOI":"10.1016\/1047-2797(94)90041-8"},{"key":"key\n\t\t\t\t20171011210521_B22","doi-asserted-by":"crossref","unstructured":"Giovannucci,E. ( 1995 ) Insulin and colon cancer. Cancer Causes Control , 6 , 164 \u2013179.","DOI":"10.1007\/BF00052777"},{"key":"key\n\t\t\t\t20171011210521_B23","unstructured":"Kaaks,R. ( 2002 ) Nutrition, energy balance and colon cancer risk: the role of insulin and insulin-like growth factor-I. IARC Sci. Publ. , 156 , 289 \u2013293."},{"key":"key\n\t\t\t\t20171011210521_B24","doi-asserted-by":"crossref","unstructured":"Peng,D.-Q., Zhao,S-P., Nie,S. and Li,J. ( 2003 ) Gene\u2013gene interaction of PPAR[gamma] and apoE affects coronary heart disease risk. Int. J. Cardiol. , 92 , 257 \u2013263.","DOI":"10.1016\/S0167-5273(03)00101-3"},{"key":"key\n\t\t\t\t20171011210521_B25","doi-asserted-by":"crossref","unstructured":"Judson,R., Brain,C., Dain,B., Windemuth,A., Ruano,G. and Reed,C. ( 2004 ) New and confirmatory evidence of an association between APOE genotype and baseline C-reactive protein in dyslipidemic individuals. Atherosclerosis , 177 , 345 \u2013351.","DOI":"10.1016\/j.atherosclerosis.2004.07.012"},{"key":"key\n\t\t\t\t20171011210521_B26","doi-asserted-by":"crossref","unstructured":"Erlinger,T.P., Platz,E.A., Rifai,N. and Helzlsouer,K.J. ( 2004 ) C-reactive protein and the risk of incident colorectal cancer. JAMA , 291 , 585 \u2013590.","DOI":"10.1001\/jama.291.5.585"},{"key":"key\n\t\t\t\t20171011210521_B27","doi-asserted-by":"crossref","unstructured":"Giovannucci,E. ( 2003 ) Diet, body weight, and colorectal cancer: a summary of the epidemiologic evidence. J. Women's Health (Larchmt) , 12 , 173 \u2013182.","DOI":"10.1089\/154099903321576574"},{"key":"key\n\t\t\t\t20171011210521_B28","unstructured":"Slattery,M.L., Potter,J., Caan,B., Edwards,S., Coates,A., Ma,K.N. and Berry,T.D. ( 1997 ) Energy balance and colon cancer\u2014beyond physical activity. Cancer Res. , 57 , 75 \u201380."},{"key":"key\n\t\t\t\t20171011210521_B29","doi-asserted-by":"crossref","unstructured":"Slattery,M.L. ( 2004 ) Physical activity and colorectal cancer. Sports Med. , 34 , 239 \u2013252.","DOI":"10.2165\/00007256-200434040-00004"},{"key":"key\n\t\t\t\t20171011210521_B30","doi-asserted-by":"crossref","unstructured":"Edwards,S., Slattery,M.L., Mori,M., Berry,T.D., Caan,B.J., Palmer,P. and Potter,J.D. ( 1994 ) Objective system for interviewer performance evaluation for use in epidemiologic studies. Am. J. Epidemiol. , 140 , 1020 \u20131028.","DOI":"10.1093\/oxfordjournals.aje.a117192"},{"key":"key\n\t\t\t\t20171011210521_B31","doi-asserted-by":"crossref","unstructured":"Slattery,M.L., Caan,B.J., Duncan,D., Berry,T.D., Coates,A. and Kerber,R. ( 1994 ) A computerized diet history questionnaire for epidemiologic studies. J. Am. Diet Assoc. , 94 , 761 \u2013766.","DOI":"10.1016\/0002-8223(94)91944-5"},{"key":"key\n\t\t\t\t20171011210521_B32","doi-asserted-by":"crossref","unstructured":"Slattery,M.L., David,R. and Jacobs,J. ( 1995 ) Assessment of ability to recall physical activity of several years ago. Ann. Epidemiol. , 5 , 292 \u2013296.","DOI":"10.1016\/1047-2797(94)00095-B"},{"key":"key\n\t\t\t\t20171011210521_B33","doi-asserted-by":"crossref","unstructured":"Slattery,M.L., Edwards,S.L., Ma,K.-N., Friedman,G.D. and Potter,J.D. ( 1997 ) Physical activity and colon cancer: a public health perspective. Ann. Epidemiol. , 7 , 137 \u2013145.","DOI":"10.1016\/S1047-2797(96)00129-9"},{"key":"key\n\t\t\t\t20171011210521_B34","unstructured":"Liu,K., Slattery,M., Jacobs,D.Jr et al . ( 1994 ) A study of the reliability and comparative validity of the cardia dietary history. Ethn. Dis. , 4 , 15 \u201327."},{"key":"key\n\t\t\t\t20171011210521_B35","doi-asserted-by":"crossref","unstructured":"Slattery,M.L., Boucher,K.M., Caan,B.J., Potter,J.D. and Ma,K.N. ( 1998 ) Eating patterns and risk of colon cancer. Am. J. Epidemiol. , 148 , 4 \u201316.","DOI":"10.1093\/aje\/148.1.4-a"},{"key":"key\n\t\t\t\t20171011210521_B36","doi-asserted-by":"crossref","unstructured":"Zivelin,A., Rosenberg,N., Peretz,H., Amit,Y., Kornbrot,N. and Seligsohn,U. ( 1997 ) Improved method for genotyping apolipoprotein E polymorphisms by a PCR-based assay simultaneously utilizing two distinct restriction enzymes. Clin. Chem. , 43 , 1657 \u20131659.","DOI":"10.1093\/clinchem\/43.9.1657"},{"key":"key\n\t\t\t\t20171011210521_B37","doi-asserted-by":"crossref","unstructured":"Slattery,M.L., Edwards,S.L., Palmer,L., Curtin,K., Morse,J., Anderson,K. and Samowitz,W. ( 2000 ) Use of archival tissue in epidemiologic studies: collection procedures and assessment of potential sources of bias. Mutat. Res. , 432 , 7 \u201314.","DOI":"10.1016\/S1383-5726(99)00010-2"},{"key":"key\n\t\t\t\t20171011210521_B38","unstructured":"Slattery,M.L., Curtin,K., Ma,K., Edwards,S., Schaffer,D., Anderson,K. and Samowitz,W. ( 2002 ) Diet activity, and lifestyle associations with p53 mutations in colon tumors. Cancer Epidemiol. Biomarkers Prev. , 11 , 541 \u2013548."},{"key":"key\n\t\t\t\t20171011210521_B39","doi-asserted-by":"crossref","unstructured":"Slattery,M.L., Anderson,K., Curtin,K., Ma,K., Schaffer,D., Edwards,S. and Samowitz,W. ( 2001 ) Lifestyle factors and Ki-ras mutations in colon cancer tumors. Mutat. Res. , 483 , 73 \u201381.","DOI":"10.1016\/S0027-5107(01)00228-7"},{"key":"key\n\t\t\t\t20171011210521_B40","doi-asserted-by":"crossref","unstructured":"Slattery,M.L., Curtin,K., Anderson,K., Ma,K.N., Ballard,L., Edwards,S., Schaffer,D., Potter,J., Leppert,M. and Samowitz,W.S. ( 2000 ) Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors. J. Natl Cancer Inst. , 92 , 1831 \u20131836.","DOI":"10.1093\/jnci\/92.22.1831"},{"key":"key\n\t\t\t\t20171011210521_B41","doi-asserted-by":"crossref","unstructured":"Hosmer,D.W. and Lemeshow,S. ( 1992 ) Confidence interval estimation of interaction. Epidemiology , 3 , 452 \u2013456.","DOI":"10.1097\/00001648-199209000-00012"},{"key":"key\n\t\t\t\t20171011210521_B42","doi-asserted-by":"crossref","unstructured":"Turunen,M.J. and Kivilaakso,E.O. ( 1981 ) Increased risk of colorectal cancer after cholecystectomy. Ann. Surg. , 194 , 639 \u2013641.","DOI":"10.1097\/00000658-198111000-00014"},{"key":"key\n\t\t\t\t20171011210521_B43","doi-asserted-by":"crossref","unstructured":"Grainger,D.J., Reckless,J. and McKilligin,E. ( 2004 ) Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo , resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice. J. Immunol. , 173 , 6366 \u20136375.","DOI":"10.4049\/jimmunol.173.10.6366"},{"key":"key\n\t\t\t\t20171011210521_B44","doi-asserted-by":"crossref","unstructured":"Moysich,K.B., Freudenheim,J.L., Baker,J.A., Ambrosone,C.B., Bowman,E.D., Schisterman,E.F., Vena,J.E. and Shields,P.G. ( 2000 ) Apolipoprotein E genetic polymorphism, serum lipoproteins, and breast cancer risk. Mol. Carcinog. , 27 , 2 \u20139.","DOI":"10.1002\/(SICI)1098-2744(200001)27:1<2::AID-MC2>3.0.CO;2-W"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/26\/8\/1422\/7089360\/bgi088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T18:26:29Z","timestamp":1586197589000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/carcin\/article\/26\/8\/1422\/2390901\/Associations-between-apoE-genotype-and-colon-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,7]]},"references-count":44,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2005,4,7]]},"published-print":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgi088","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,8]]},"published":{"date-parts":[[2005,4,7]]}}}