{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:52:10Z","timestamp":1761918730078},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"DOI":"10.1093\/carcin\/bgi195","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T00:14:35Z","timestamp":1122596075000},"page":"2157-2163","source":"Crossref","is-referenced-by-count":14,"title":["Glutathione S -transferase T1 polymorphisms are associated with outcome in colorectal cancer"],"prefix":"10.1093","volume":"26","author":[{"given":"R.","family":"Rajagopal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Deakin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.S.","family":"Fawole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.B.","family":"Elder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Elder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.C.","family":"Strange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,7,28]]},"reference":[{"key":"key\n\t\t\t\t20171011215700_B1","unstructured":"Mortality Statistics ( 2003 ) Review of the Registrar General on deaths by cause, sex and age, in England and Wales , 2002. Office for National Statistics."},{"key":"key\n\t\t\t\t20171011215700_B2","unstructured":"Cancer Facts and Figures 2003. American Cancer Society."},{"key":"key\n\t\t\t\t20171011215700_B3","doi-asserted-by":"crossref","unstructured":"Evans,D.G., Walsh,S., Jeacock,J., Robinson,C,. Hadfield,L., Davies,D.R. and Kingston,R. ( 1997 ) Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer. Br. J. Surg. , 84 , 1281 \u20131285.","DOI":"10.1002\/bjs.1800840924"},{"key":"key\n\t\t\t\t20171011215700_B4","doi-asserted-by":"crossref","unstructured":"Houlston,R.S. and Tomlinson,I.P. ( 2001 ) Polymorphisms and colorectal tumor risk. Gastroenterology , 121 , 282 \u2013301.","DOI":"10.1053\/gast.2001.26265"},{"key":"key\n\t\t\t\t20171011215700_B5","doi-asserted-by":"crossref","unstructured":"Butler, W.J., Ryan,P. and Roberts-Thomson,I.C. ( 2001 ) Metabolic genotypes and risk for colorectal cancer. J. Gastroenterol. Hepatol. , 16 , 631 \u2013635.","DOI":"10.1046\/j.1440-1746.2001.02501.x"},{"key":"key\n\t\t\t\t20171011215700_B6","unstructured":"Strange,R.C. and Fryer,A.A. ( 1999 ) The glutathione S -transferases: influence of polymorphism on susceptibility to non familial cancers. In Boffetta,P., Caporaso,N., Cuzick,J., Lang,M. and Vineis,P. (eds) Metabolic Polymorphisms and Cancer . IARC Scientific Publications, Lyon, pp. 303\u2013322."},{"key":"key\n\t\t\t\t20171011215700_B7","doi-asserted-by":"crossref","unstructured":"Strange,R.C. and Fryer,A.A. ( 2004 ) Glutathione S -transferase genotype\u2013Clinical implications. In Fuchs,J. and Podda,M. (eds) Encyclopedia of Medical Genomics and Proteomics . Marcel Dekker Inc., New York. pp. 536\u2013542.","DOI":"10.3109\/9780203997352.110"},{"key":"key\n\t\t\t\t20171011215700_B8","doi-asserted-by":"crossref","unstructured":"Webb,G., Vaska,V., Coggan,M. and Board P. ( 1996 ) Chromosomal localization of the gene for the human theta class glutathione transferase ( GSTT1 ). Genomics , 33 , 121 \u2013123.","DOI":"10.1006\/geno.1996.0167"},{"key":"key\n\t\t\t\t20171011215700_B9","doi-asserted-by":"crossref","unstructured":"Pemble,S., Schroeder,K.R., Spencer,S.R., Meyer,D.J., Hallier,E., Bolt,H.M., Ketterer,B. and Taylor,J.B. ( 1994 ) Human glutathione S -transferase theta ( GSTT1 ): cDNA cloning and the characterization of a genetic polymorphism. Biochem. J. , 300 , 271 \u2013276.","DOI":"10.1042\/bj3000271"},{"key":"key\n\t\t\t\t20171011215700_B10","doi-asserted-by":"crossref","unstructured":"Hayes,J.D. and Strange,R.C. ( 2000 ) Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology , 61 , 154 \u2013166.","DOI":"10.1159\/000028396"},{"key":"key\n\t\t\t\t20171011215700_B11","doi-asserted-by":"crossref","unstructured":"Hengstler,J.G., Arand,M., Herrero,M.E. and Oesch,F. ( 1998 ) Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. Recent Results Cancer Res. , 154 , 47 \u201385.","DOI":"10.1007\/978-3-642-46870-4_4"},{"key":"key\n\t\t\t\t20171011215700_B12","doi-asserted-by":"crossref","unstructured":"Xu,X., Wiencke,J.K., Niu,T., Wang,M., Watanabe,H., Kelsey,K.T. and Christiani,D.C. ( 1998 ) Benzene exposure, glutathione S -transferase theta homozygous deletion, and sister chromatid exchanges. Am. J. Ind. Med. , 33 , 157 \u2013163.","DOI":"10.1002\/(SICI)1097-0274(199802)33:2<157::AID-AJIM7>3.0.CO;2-V"},{"key":"key\n\t\t\t\t20171011215700_B13","doi-asserted-by":"crossref","unstructured":"Kerb,R., Brockmoller,J., Schlagenhaufer,R., Sprenger,R., Roots,I. and Brinkmann,U. ( 2002 ) Influence of GSTT1 and GSTM1 genotypes on sunburn sensitivity. Am. J. Pharmacogenomics , 2 , 147 \u2013154.","DOI":"10.2165\/00129785-200202020-00007"},{"key":"key\n\t\t\t\t20171011215700_B14","doi-asserted-by":"crossref","unstructured":"Ramsay,H.M., Harden,P.N., Hawley,C.M., Nicol,D.L., Lovatt,T.J., Smith,A.G., Strange,R.C. and Fryer,A.A. ( 2005 ) Polymorphisms in glutathione S -transferases and non-melanoma skin cancer risk in Australian renal transplant recipients. Carcinogenesis , 26 , 185 \u2013191.","DOI":"10.1093\/carcin\/bgh291"},{"key":"key\n\t\t\t\t20171011215700_B15","doi-asserted-by":"crossref","unstructured":"Hurst,R., Bao,Y., Jemth,P., Mannervik,B. and Williamson,G. ( 1998 ) Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases. Biochem. J. , 332 , 97 \u2013100.","DOI":"10.1042\/bj3320097"},{"key":"key\n\t\t\t\t20171011215700_B16","doi-asserted-by":"crossref","unstructured":"Jass,J.R. ( 1986 ) Lymphocytic infiltration and survival in rectal cancer. J. Clin. Path. , 39 , 585 \u2013589.","DOI":"10.1136\/jcp.39.6.585"},{"key":"key\n\t\t\t\t20171011215700_B17","doi-asserted-by":"crossref","unstructured":"Deakin,M., Elder,J., Hendrickse,C. et al . ( 1996 ) Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: Studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancer. Carcinogenesis , 17 , 881 \u2013884.","DOI":"10.1093\/carcin\/17.4.881"},{"key":"key\n\t\t\t\t20171011215700_B18","doi-asserted-by":"crossref","unstructured":"Zhang,H., Ahmadi,A., Arbman,G., Zdolsek,J., Carstensen,J., Nordenskjold,B., Soderkvist,P. and Sun,X.F. ( 1999 ) Glutathione S -transferase T1 and M1 genotypes in normal mucosa, transitional mucosa and colorectal adenocarcinoma. Int. J. Cancer , 84 , 135 \u2013138.","DOI":"10.1002\/(SICI)1097-0215(19990420)84:2<135::AID-IJC7>3.0.CO;2-C"},{"key":"key\n\t\t\t\t20171011215700_B19","unstructured":"Laso,N., Lafuente,M.J., Mas,S., Trias,M., Ascaso,C., Molina,R., Ballesta,A., Rodriguez,F. and Lafuente,A. ( 2002 ) Glutathione S -transferase ( GSTM1 and GSTT1 )-dependent risk for colorectal cancer. Anticancer Res. , 22 , 3399 \u20133403."},{"key":"key\n\t\t\t\t20171011215700_B20","doi-asserted-by":"crossref","unstructured":"Nascimento,H., Coy,C.S., Teori,M.T., Boin,I.F., Goes,J.R., Costa,F.F. and Lima,C.S. ( 2003 ) Possible influence of glutathione S -transferase GSTT1 null genotype on age of onset of sporadic colorectal adenocarcinoma. Dis. Colon Rectum , 46 , 510 \u2013515.","DOI":"10.1007\/s10350-004-6591-4"},{"key":"key\n\t\t\t\t20171011215700_B21","doi-asserted-by":"crossref","unstructured":"Chenevix-Trench,G., Young,J., Coggan,M. and Board,P. ( 1995 ) Glutathione S -transferase M1 and T1 polymorphisms: susceptibility to colon cancer and age of onset. Carcinogenesis , 16 , 1655 \u20131657.","DOI":"10.1093\/carcin\/16.7.1655"},{"key":"key\n\t\t\t\t20171011215700_B22","doi-asserted-by":"crossref","unstructured":"Katoh,T., Nagata,N., Kuroda,Y., Itoh,H Kawahara,A., Kuroki,N., Ookuma,R. and Bell,D.A. ( 1996 ) Glutathione S -transferase M1 ( GSTM1 ) and T1 ( GSTT1 ) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. Carcinogenesis17 , 1855 \u20131859.","DOI":"10.1093\/carcin\/17.9.1855"},{"key":"key\n\t\t\t\t20171011215700_B23","unstructured":"Welfare,M., Monesola Adeokun,A., Bassendine,M.F. and Daly,A.K. ( 1999 ) Polymorphisms in GSTP1 , GSTM1 and GSTT1 and susceptibility to colorectal cancer. Cancer Epidemiol. Biomarkers Prev. , 8 , 289 \u2013292."},{"key":"key\n\t\t\t\t20171011215700_B24","doi-asserted-by":"crossref","unstructured":"Ye,Z. and Parry,J.M. ( 2002 ) Genetic polymorphisms in the cytochrome P450 1A1, glutathione S -transferase M1 and T1, and susceptibility to colon cancer. Teratog. Carcinog. Mutagen. , 22 , 385 \u2013392.","DOI":"10.1002\/tcm.10035"},{"key":"key\n\t\t\t\t20171011215700_B25","doi-asserted-by":"crossref","unstructured":"Saadat,I. and Saadat,M. ( 2001 ) Glutathione S -transferase M1 and T1 null genotypes and the risk of gastric and colorectal cancers. Cancer Lett. , 169 , 21 \u201326.","DOI":"10.1016\/S0304-3835(01)00550-X"},{"key":"key\n\t\t\t\t20171011215700_B26","unstructured":"Sgambato,A., Campisi,B., Zupa,A., Bochicchio,A., Romano,G., Tartarone,A., Galasso,R., Traficante,A. and Cittadini,A. ( 2002 ) Glutathione S -transferase (GST) polymorphisms as risk factors for cancer in a highly homogeneous population from southern Italy. Anticancer Res. , 22 , 3647 \u20133652."},{"key":"key\n\t\t\t\t20171011215700_B27","doi-asserted-by":"crossref","unstructured":"Stoehlmacher,J., Park,D.J., Zhang,W., Groshen,S., Tsao-Wei,D.D., Yu,M.C. and Lenz,H.J. ( 2002 ) Association between glutathione S -transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer. J. Natl Cancer Inst. , 94 , 936 \u2013942.","DOI":"10.1093\/jnci\/94.12.936"},{"key":"key\n\t\t\t\t20171011215700_B28","doi-asserted-by":"crossref","unstructured":"Nelson,H.H., Wiencke,J.K., Christiani,D.C., Cheng,T.J., Zuo,Z.F., Schwartz,B.S., Lee,B.K., Spitz,M.R., Wang,M. and Xu,X. ( 1995 ) Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S -transferase theta. Carcinogenesis , 16 , 1243 \u20131245.","DOI":"10.1093\/carcin\/16.5.1243"},{"key":"key\n\t\t\t\t20171011215700_B29","doi-asserted-by":"crossref","unstructured":"Ramachandran,S., Fryer,A.A., Smith,A.G., Lear,J.T., Bowers,B., Griffiths,C.E.M., Jones,P.W. and Strange,R.C. ( 2000 ) Basal cell carcinoma: Tumor clustering is associated with increased accrual in high-risk subgroups. Cancer , 89 , 1012 \u20131018.","DOI":"10.1002\/1097-0142(20000901)89:5<1012::AID-CNCR10>3.0.CO;2-O"},{"key":"key\n\t\t\t\t20171011215700_B30","unstructured":"American Joint Committee on Cancer. ( 2003 ) Cancer Staging Manual . 6th edn. Springer-Verlag, New York."},{"key":"key\n\t\t\t\t20171011215700_B31","doi-asserted-by":"crossref","unstructured":"Barnett,Y.A. and Barnett,C.R. ( 1998 ) DNA damage and mutation: contributors to the age-related alterations in T cell-mediated immune responses? Mech. Ageing. Devel. , 102 , 165 \u2013175.","DOI":"10.1016\/S0047-6374(98)00018-9"},{"key":"key\n\t\t\t\t20171011215700_B32","doi-asserted-by":"crossref","unstructured":"Hubbard,A.K. ( 1999 ) Effects of xenobiotics on macrophage function: evaluation in vitro . Methods , 19 , 8 \u201316.","DOI":"10.1006\/meth.1999.0822"},{"key":"key\n\t\t\t\t20171011215700_B33","doi-asserted-by":"crossref","unstructured":"Barcellos-Hoff,M.H. ( 1998 ) How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues. Radiat. Res. , 150 , S109 \u2013S120.","DOI":"10.2307\/3579813"},{"key":"key\n\t\t\t\t20171011215700_B34","doi-asserted-by":"crossref","unstructured":"Licastro,F., Candore,G., Lio,D., Porcellini,E., Colonna-Romano,G., Franchesci,C. and Caruso,C. ( 2005 ) Innate immunity and inflammation of ageing: a key for understanding age-related diseases. Immunity Ageing , 2 , 8 .","DOI":"10.1186\/1742-4933-2-8"},{"key":"key\n\t\t\t\t20171011215700_B35","doi-asserted-by":"crossref","unstructured":"Ferraz,J.M., Zinzindohoue,F., Lecomte,T., Cugnenc,P.H., Loriot,M.A., Beaune,P., Stucker,I., Berger,A. and Laurent-Puig,P. ( 2004 ) Impact of GSTT1 , GSTM1 , GSTP1 and NAT2 genotypes on KRAS2 and TP53 gene mutations in colorectal cancer. Int. J. Cancer , 110 , 183 \u2013187.","DOI":"10.1002\/ijc.20124"},{"key":"key\n\t\t\t\t20171011215700_B36","doi-asserted-by":"crossref","unstructured":"Atkins,D., Breuckmann,A., Schmahl,G.E., Binner,P., Ferrone,S., Krummenauer,F., Storkel,S. and Seliger,B. ( 2004 ) MHC class I antigen processing pathway defects, ras mutations and disease stage in colorectal carcinoma. Int. J. Cancer , 109 , 265 \u2013273.","DOI":"10.1002\/ijc.11681"},{"key":"key\n\t\t\t\t20171011215700_B37","unstructured":"Howells,R.E.J., Redman,C.W.E., Dhar,K.K., Sarhanis,P., Musgrove,C., Jones,P.W., Alldersea,J., Fryer,A.A., Hoban,P.R. and Strange,R.C. ( 1998 ) Association of glutathione S-transferase GSTM1 and GSTT1 null genotypes with clinical outcome in epithelial ovarian cancer. Clin. Cancer Res. , 4 , 2439 \u20132445."},{"key":"key\n\t\t\t\t20171011215700_B38","doi-asserted-by":"crossref","unstructured":"Budarf,M., McDonald,T., Sellinger,B., Kozak,C., Graham,C. and Wistow,G. ( 1997 ) Localization of the human gene for macrophage migration inhibitory factor (MIF) to chromosome 22q11.2. Genomics , 39 , 235 \u2013236.","DOI":"10.1006\/geno.1996.4505"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/26\/12\/2157\/7088641\/bgi195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T11:53:39Z","timestamp":1586346819000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/carcin\/article\/26\/12\/2157\/2390797\/Glutathione-S-transferase-T1-polymorphisms-are"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,28]]},"references-count":38,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2005,7,28]]},"published-print":{"date-parts":[[2005,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgi195","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,12]]},"published":{"date-parts":[[2005,7,28]]}}}