{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:09:45Z","timestamp":1783634985675,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,1]]},"DOI":"10.1093\/carcin\/bgi338","type":"journal-article","created":{"date-parts":[[2006,1,8]],"date-time":"2006-01-08T01:12:55Z","timestamp":1136682775000},"page":"1404-1409","source":"Crossref","is-referenced-by-count":27,"title":["Lack of stimulatory activity of a Phytoestrogen-containing soy extract on the growth of breast cancer tumors in mice"],"prefix":"10.1093","volume":"27","author":[{"given":"Daniela","family":"Gallo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Ferlini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Fabrizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Prislei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,1,7]]},"reference":[{"key":"key\n\t\t\t\t20171011193334_B1","unstructured":"Ferlay,J., Bray,F., Pisani,P. and Parkin,D.M. ( 2004 ) GLOBOCAN 2002: Cancer Incidence, Mortality and Prevalence Worldwide. IARC Cancer Base No. 5. version 2.0, IARC, Lyon"},{"key":"key\n\t\t\t\t20171011193334_B2","doi-asserted-by":"crossref","unstructured":"Messina,M. and Barnes,S. ( 1991 ) The role of soy products in reducing risk of cancer. J. Natl Cancer Inst. , 83 , 541 \u2013546","DOI":"10.1093\/jnci\/83.8.541"},{"key":"key\n\t\t\t\t20171011193334_B3","doi-asserted-by":"crossref","unstructured":"Lee,M.M., Lin,S.S., Wrensch,M.R., Adler,S.R. and Eisenberg,D. ( 2000 ) Alternative therapies used by women with breast cancer in four ethnic populations. J. Natl Cancer Inst. , 92 , 42 \u201347","DOI":"10.1093\/jnci\/92.1.42"},{"key":"key\n\t\t\t\t20171011193334_B4","doi-asserted-by":"crossref","unstructured":"Morris,K.T., Johnson,N., Homer,L. and Walts,D. ( 2000 ) A comparison of complementary therapy use between breast cancer patients and patients with other primary tumor sites. Am. J. Surg. , 179 , 407 \u2013411","DOI":"10.1016\/S0002-9610(00)00358-5"},{"key":"key\n\t\t\t\t20171011193334_B5","doi-asserted-by":"crossref","unstructured":"Newton,K.M., Buist,D.S., Keenan,N.L., Anderson,L.A. and LaCroix,A.Z. ( 2002 ) Use of alternative therapies for menopause symptoms: results of a population-based survey. Obstet. Gynecol. , 100 , 18 \u201325","DOI":"10.1097\/00006250-200207000-00004"},{"key":"key\n\t\t\t\t20171011193334_B6","doi-asserted-by":"crossref","unstructured":"Messina,M.J. and Loprinzi,C.L. ( 2001 ) Soy for breast cancer survivors: a critical review of the literature. J. Nutr. , 131 (Suppl 11) 3095S \u2013108S Review.","DOI":"10.1093\/jn\/131.11.3095S"},{"key":"key\n\t\t\t\t20171011193334_B7","doi-asserted-by":"crossref","unstructured":"Gallo,D., Zannoni,G.F., Apollonio,P., Martinelli,E., Ferlini,C., Passetti,G., Riva,A., Morazzoni,P., Bombardelli,E. and Scambia,G. ( 2005 ) Characterization of the pharmacological profile of a standardized soy extract in the ovariectomized rat model of menopause: effects on bone, uterus, and lipid profile. Menopause , 12 , 589 \u2013600","DOI":"10.1097\/01.GME.0000156348.61767.D5"},{"key":"key\n\t\t\t\t20171011193334_B8","doi-asserted-by":"crossref","unstructured":"Gallo,D., Zannoni,G.F., Martinelli,E., Ferlini,C., Fabrizi,M., Riva,A., Morazzoni,P., Bombardelli,E. and Scambia,G. ( 2006 ) Estradiol and phytoestrogens differently influence the rodent postmenopausal mammary gland. Menopause , 13 , 72 \u201379","DOI":"10.1097\/01.gme.0000191208.05491.94"},{"key":"key\n\t\t\t\t20171011193334_B9","doi-asserted-by":"crossref","unstructured":"Morton,M.S., Arisaka,O., Miyake,N., Morgan,L.D. and Evans,B.A. ( 2002 ) Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. J. Nutr. , 132 , 3168 \u20133171","DOI":"10.1093\/jn\/131.10.3168"},{"key":"key\n\t\t\t\t20171011193334_B10","doi-asserted-by":"crossref","unstructured":"Scambia,G., Mango,D., Signorile,P.G., Anselmi Angeli,R.A., Palena,C., Gallo,D., Bombardelli,E., Morazzoni,P., Riva,A. and Mancuso,S. ( 2000 ) Clinical effects of a standardized soy extract in postmenopausal women: a pilot study. Menopause , 7 , 105 \u2013111","DOI":"10.1097\/00042192-200007020-00006"},{"key":"key\n\t\t\t\t20171011193334_B11","doi-asserted-by":"crossref","unstructured":"Corbett,T., Valeriote,F., LoRusso,P., Polin,L., Panchapor,C., Pugh,S., White,K., Knight,J., Demchik,L., Jones,J., Jones,L. and Lisow,L. ( 1997 ) In vivo methods for screening and preclinical testing. In Teicher,BA. (ed) Anticancer Drug Development Guide , Humana Press, Totowa, NJ, pp. 75\u201399","DOI":"10.1007\/978-1-4615-8152-9_5"},{"key":"key\n\t\t\t\t20171011193334_B12","unstructured":"Passaniti,A., Taylor,R.M., Pili,R., Guo,Y., Long,P.V., Haney,J.A., Pauly,R.R., Grant,D.S. and Martin,G.R. ( 1992 ) A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab. Invest. , 67 , 519 \u2013528"},{"key":"key\n\t\t\t\t20171011193334_B13","doi-asserted-by":"crossref","unstructured":"Wang,T.T., Sathyamoorthy,N. and Phang,J.M. ( 1996 ) Molecular effects of genistein on estrogen receptor mediated pathways. Carcinogenesis , 17 , 271 \u2013275","DOI":"10.1093\/carcin\/17.2.271"},{"key":"key\n\t\t\t\t20171011193334_B14","unstructured":"Hsieh,C.Y., Santell,R.C., Haslam,S.Z. and Helferich,W.G. ( 1998 ) Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo . Cancer Res. , 58 , 3833 \u20133838"},{"key":"key\n\t\t\t\t20171011193334_B15","doi-asserted-by":"crossref","unstructured":"Miodini,P., Fioravanti,L., Di Fronzo,G. and Cappelletti,V. ( 1999 ) The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function. Br J Cancer. , 80 , 1150 \u20131155","DOI":"10.1038\/sj.bjc.6690479"},{"key":"key\n\t\t\t\t20171011193334_B16","doi-asserted-by":"crossref","unstructured":"Maggiolini,M., Bonofiglio,D., Marsico,S., Panno,M.L., Cenni,B., Picard,D. and Ando,S. ( 2001 ) Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol. Pharmacol , 60 , 595 \u2013602","DOI":"10.1016\/S0026-895X(24)12623-5"},{"key":"key\n\t\t\t\t20171011193334_B17","doi-asserted-by":"crossref","unstructured":"Ju,Y.H., Allred,C.D., Allred,K.F., Karko,K.L., Doerge,D.R. and Helferich,W.G. ( 2001 ) Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J. Nutr. , 131 , 2957 \u20132962","DOI":"10.1093\/jn\/131.11.2957"},{"key":"key\n\t\t\t\t20171011193334_B18","unstructured":"Allred,C.D., Allred,K.F., Ju,Y.H., Virant,S.M. and Helferich,W.G. ( 2001 ) Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner. Cancer Res. , 61 , 5045 \u20135050"},{"key":"key\n\t\t\t\t20171011193334_B19","doi-asserted-by":"crossref","unstructured":"Allred,C.D., Ju,Y.H., Allred,K.F., Chang,J. and Helferich,W.G. ( 2001 ) Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis , 22 , 1667 \u20131673","DOI":"10.1093\/carcin\/22.10.1667"},{"key":"key\n\t\t\t\t20171011193334_B20","doi-asserted-by":"crossref","unstructured":"Allred,C.D., Allred,K.F., Ju,Y.H., Goeppinger,T.S., Doerge,D.R. and Helferich,W.G. ( 2004 ) Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis , 25 , 1649 \u20131657","DOI":"10.1093\/carcin\/bgh178"},{"key":"key\n\t\t\t\t20171011193334_B21","unstructured":"Shao,Z.M., Wu,J., Shen,Z.Z. and Barsky,S.H. ( 1998 ) Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res. , 58 , 4851 \u20134857"},{"key":"key\n\t\t\t\t20171011193334_B22","doi-asserted-by":"crossref","unstructured":"Jeffery,E. ( 2005 ) Component interactions for efficacy of functional foods. J. Nutr. , 135 , 1223 \u20131225","DOI":"10.1093\/jn\/135.5.1223"},{"key":"key\n\t\t\t\t20171011193334_B23","doi-asserted-by":"crossref","unstructured":"Brown,A.M., Jeltsch,J.M., Roberts,M. and Chambon,P. ( 1984 ) Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7. Proc. Natl Acad. Sci. USA , 81 , 6344 \u20136348","DOI":"10.1073\/pnas.81.20.6344"},{"key":"key\n\t\t\t\t20171011193334_B24","doi-asserted-by":"crossref","unstructured":"Cho,H., Aronica,S.M. and Katzenellenbogen,B.S. ( 1994 ) Regulation of progesterone receptor gene expression in MCF-7 breast cancer cells: a comparison of the effects of cyclic adenosine 3\u2032,5\u2032-monophosphate, estradiol, insulin-like growth factor-I, and serum factors. Endocrinology , 134 , 658 \u2013664","DOI":"10.1210\/endo.134.2.7507831"},{"key":"key\n\t\t\t\t20171011193334_B25","unstructured":"Altucci,L., Addeo,R., Cicatiello,L., Dauvois,S., Parker,M.G., Truss,M., Beato,M., Sica,V., Bresciani,F. and Weisz,A. ( 1996 ) 17\u03b2-estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells. Oncogene , 12 , 2315 \u20132324"},{"key":"key\n\t\t\t\t20171011193334_B26","doi-asserted-by":"crossref","unstructured":"Li,Y. and Sarkar,F.H. ( 2002 ) Gene expression profiles of genistein-treated PC3 prostate cancer cells. J. Nutr. , 132 , 3623 \u20133631","DOI":"10.1093\/jn\/132.12.3623"},{"key":"key\n\t\t\t\t20171011193334_B27","unstructured":"Ghosh,M.G., Thompson,D.A. and Weigel,R.J. ( 2000 ) PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. Cancer Res. , 60 , 6367 \u20136375"},{"key":"key\n\t\t\t\t20171011193334_B28","doi-asserted-by":"crossref","unstructured":"Borgono,C.A. and Diamandis,E.P. ( 2004 ) The emerging roles of human tissue kallikreins in cancer. Nat. Rev. Cancer , 4 , 876 \u2013890. Review","DOI":"10.1038\/nrc1474"},{"key":"key\n\t\t\t\t20171011193334_B29","doi-asserted-by":"crossref","unstructured":"Esemuede,N., Lee,T., Pierre-Paul,D., Sumpio,B.E and Gahtan,V. ( 2004 ) The role of thrombospondin-1 in human disease. J. Surg. Res. , 122 , 135 \u2013142. Review.","DOI":"10.1016\/j.jss.2004.05.015"},{"key":"key\n\t\t\t\t20171011193334_B30","doi-asserted-by":"crossref","unstructured":"Derynck,R., Akhurst,R.J. and Balmain,A. ( 2001 ) TGF-beta signaling in tumor suppression and cancer progression. Nat.Genet. , 29 , 117 \u2013129. Review.","DOI":"10.1038\/ng1001-117"},{"key":"key\n\t\t\t\t20171011193334_B31","doi-asserted-by":"crossref","unstructured":"Muraoka-Cook,R.S., Dumont,N. and Arteaga,C.L. ( 2005 ) Dual role of transforming growth factor beta in mammary tumorigenesis and metastatic progression. Clin. Cancer Res. , 11 , 937s \u2013943s. Review","DOI":"10.1158\/1078-0432.937s.11.2"},{"key":"key\n\t\t\t\t20171011193334_B32","doi-asserted-by":"crossref","unstructured":"Gallo,D., Giacomelli,S., Cantelmo,F. et al . ( 2001 ) Chemoprevention of DMBA-induced mammary cancer in rats by dietary soy. Breast Cancer Res. Treat. , 69 , 153 \u2013164","DOI":"10.1023\/A:1012414119944"},{"key":"key\n\t\t\t\t20171011193334_B33","doi-asserted-by":"crossref","unstructured":"Fotsis,T., Pepper,M., Adlercreutz,H., Fleischmann,G., Hase,T., Montesano,R. and Schweigerer,L. ( 1993 ) Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc. Natl Acad. Sci. USA , 90 , 2690 \u20132694","DOI":"10.1073\/pnas.90.7.2690"},{"key":"key\n\t\t\t\t20171011193334_B34","doi-asserted-by":"crossref","unstructured":"Upmalis,D.H., Lobo,R., Bradley,L., Warren,M., Cone,F.L. and Lamia,C.A. ( 2000 ) Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study. Menopause , 7 , 236 \u2013242","DOI":"10.1097\/00042192-200007040-00005"},{"key":"key\n\t\t\t\t20171011193334_B35","doi-asserted-by":"crossref","unstructured":"Kritz-Silverstein,D., Von Muhlen,D., Barrett-Connor,E. and Bressel,M.A. ( 2003 ) Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study. Menopause , 10 , 196 \u2013202","DOI":"10.1097\/00042192-200310030-00004"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/27\/7\/1404\/7090379\/bgi338.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T23:50:29Z","timestamp":1736207429000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/carcin\/article\/27\/7\/1404\/2391014\/Lack-of-stimulatory-activity-of-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,7]]},"references-count":35,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2006,1,7]]},"published-print":{"date-parts":[[2006,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgi338","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,7]]},"published":{"date-parts":[[2006,1,7]]}}}