{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:21:46Z","timestamp":1790968906409,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1093\/carcin\/bgn024","type":"journal-article","created":{"date-parts":[[2008,2,16]],"date-time":"2008-02-16T01:39:41Z","timestamp":1203125981000},"page":"754-761","source":"Crossref","is-referenced-by-count":45,"title":["MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population"],"prefix":"10.1093","volume":"29","author":[{"given":"San San","family":"Lum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Wan","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanyan","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanaga","family":"Sabapathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,2,14]]},"reference":[{"key":"key\n\t\t\t\t20170503053511_bib1","volume-title":"GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide. IARC Cancer Base No. 5. Version 10","author":"Ferlay","year":"2001"},{"key":"key\n\t\t\t\t20170503053511_bib2","first-page":"51","article-title":"Breast cancer in young women: case report and a review","volume":"10","author":"Batori","year":"2006","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"key\n\t\t\t\t20170503053511_bib3","first-page":"666","article-title":"Breast","volume-title":"Current Medical Diagnosis and Treatment","author":"Giuliano","year":"1998"},{"key":"key\n\t\t\t\t20170503053511_bib4","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(01)06524-2","article-title":"Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease","volume":"358","author":"Collaborative Group on Hormonal Factors in Breast Cancer","year":"2001","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170503053511_bib5","volume-title":"Trends in Cancer Incidence in Singapore 1968\u20132002. Singapore Cancer Registry Report 6","author":"Seow","year":"2004"},{"key":"key\n\t\t\t\t20170503053511_bib6","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1158\/1078-0432.CCR-04-0085","article-title":"Conservation of breast cancer molecular subtypes and transcriptional patterns of tumor progression across distinct ethnic populations","volume":"10","author":"Yu","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"key\n\t\t\t\t20170503053511_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/bcr932","article-title":"The changing global patterns of female breast cancer incidence and mortality","volume":"6","author":"Bray","year":"2004","journal-title":"Breast Cancer Res."},{"key":"key\n\t\t\t\t20170503053511_bib8","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nrc864","article-title":"Live or let die: the cell's response to p53","volume":"2","author":"Vousden","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20170503053511_bib9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/humu.10081","article-title":"The IARC TP53 database: new online mutation analysis and recommendations to users","volume":"19","author":"Olivier","year":"2002","journal-title":"Hum. Mutat."},{"key":"key\n\t\t\t\t20170503053511_bib10","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1038\/sj.onc.1210302","article-title":"TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes","volume":"26","author":"Petitjean","year":"2007","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170503053511_bib11","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1073\/pnas.89.14.6413","article-title":"Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein","volume":"89","author":"Frebourg","year":"1992","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170503053511_bib12","first-page":"3245","article-title":"Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families","volume":"57","author":"Varley","year":"1997","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170503053511_bib13","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1093","article-title":"The codon 72 polymorphic variants of p53 have markedly different apoptotic potential","volume":"33","author":"Dumont","year":"2003","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170503053511_bib14","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1038\/sj.onc.1209405","article-title":"Trp53-dependent DNA-repair is affected by the codon 72 polymorphism","volume":"25","author":"Siddique","year":"2006","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170503053511_bib15","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/ijc.11548","article-title":"P53 polymorphic variants at codon 72 exert different effects on cell cycle progression","volume":"108","author":"Pim","year":"2004","journal-title":"Int. J. Cancer"},{"key":"key\n\t\t\t\t20170503053511_bib16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/30400","article-title":"Role of a p53 polymorphism in the development of human papillomavirus-associated cancer","volume":"393","author":"Storey","year":"1998","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170503053511_bib17","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/carcin\/17.6.1313","article-title":"p53 polymorphisms and haplotypes in breast cancer","volume":"17","author":"Sjalander","year":"1996","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170503053511_bib18","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1289\/ehp.97105s4919","article-title":"Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis","volume":"105","author":"Weston","year":"1997","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20170503053511_bib19","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1006\/mcbr.2000.0241","article-title":"P53 codon 72 polymorphism as a risk factor in the development of breast cancer","volume":"3","author":"Papadakis","year":"2000","journal-title":"Mol. Cell Biol. Res. Commun."},{"key":"key\n\t\t\t\t20170503053511_bib20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cdp.2006.09.007","article-title":"Evidence for an association of TP53 codon 72 polymorphism with breast cancer risk","volume":"30","author":"Damin","year":"2006","journal-title":"Cancer Detect. Prev."},{"key":"key\n\t\t\t\t20170503053511_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cancergencyto.2006.09.010","article-title":"Polymorphism of TP53 codon 72 showed no association with breast cancer in Iranian women","volume":"173","author":"Khadang","year":"2007","journal-title":"Cancer Genet. Cytogenet."},{"key":"key\n\t\t\t\t20170503053511_bib22","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1196\/annals.1299.137","article-title":"No evidence of correlation between p53 codon 72 polymorphism and risk of bladder or breast carcinoma in Tunisian patients","volume":"1010","author":"Mabrouk","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"key\n\t\t\t\t20170503053511_bib23","first-page":"711","article-title":"P53 codon 72 polymorphism in breast cancer","volume":"10","author":"Buyru","year":"2003","journal-title":"Oncol. Rep."},{"key":"key\n\t\t\t\t20170503053511_bib24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/mutage\/geg008","article-title":"TP53 polymorphisms and lung cancer risk: a systematic review and meta-analysis","volume":"18","author":"Matakidou","year":"2003","journal-title":"Mutagenesis"},{"key":"key\n\t\t\t\t20170503053511_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1158\/1055-9965.EPI-083-3","article-title":"P53 codon 72 polymorphism and cervical neoplasia: a meta-analysis review","volume":"13","author":"Koushik","year":"2004","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"key\n\t\t\t\t20170503053511_bib26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000154228","article-title":"Is p53 polymorphism maintained by natural selection?","volume":"44","author":"Beckman","year":"1994","journal-title":"Hum. Hered."},{"key":"key\n\t\t\t\t20170503053511_bib27","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1158\/1055-9965.EPI-05-0153","article-title":"Evidence for selective expression of the p53 codon 72 polymorphs: implications in cancer development","volume":"14","author":"Siddique","year":"2005","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"key\n\t\t\t\t20170503053511_bib28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cell.2004.11.022","article-title":"A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans","volume":"119","author":"Bond","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170503053511_bib29","doi-asserted-by":"crossref","first-page":"16297","DOI":"10.1073\/pnas.0508390102","article-title":"Detection of functional single-nucleotide polymorphisms that affect apoptosis","volume":"102","author":"Harris","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170503053511_bib30","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1158\/0008-5472.CAN-06-0180","article-title":"MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner","volume":"66","author":"Bond","year":"2006","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170503053511_bib31","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/sj.onc.1210199","article-title":"A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans","volume":"26","author":"Bond","year":"2007","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170503053511_bib32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00008571-200201000-00012","article-title":"Genetic polymorphisms of UDP-glucuronosyltransferase in Asians: uGT1A1*28 is a common allele in Indians","volume":"12","author":"Balram","year":"2002","journal-title":"Pharmacogenetics"},{"key":"key\n\t\t\t\t20170503053511_bib33","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/sim.2010","article-title":"A method for meta-analysis of molecular association studies","volume":"24","author":"Thakkinstian","year":"2005","journal-title":"Stat. Med."},{"key":"key\n\t\t\t\t20170503053511_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.canlet.2005.09.003","article-title":"No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer","volume":"240","author":"Campbell","year":"2006","journal-title":"Cancer Lett."},{"key":"key\n\t\t\t\t20170503053511_bib35","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/jnci\/djj245","article-title":"Association of breast cancer outcome with status of p53 and MDM2 SNP309","volume":"98","author":"Boersma","year":"2006","journal-title":"J. Natl Cancer Inst."},{"key":"key\n\t\t\t\t20170503053511_bib36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2407-6-80","article-title":"Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers","volume":"6","author":"Copson","year":"2006","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t20170503053511_bib37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10689-004-9538-y","article-title":"Cancer in Jews: introduction and overview","volume":"3","author":"Lynch","year":"2004","journal-title":"Fam. Cancer"},{"key":"key\n\t\t\t\t20170503053511_bib38","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.canlet.2005.09.019","article-title":"Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population","volume":"240","author":"Ma","year":"2006","journal-title":"Cancer Lett."},{"key":"key\n\t\t\t\t20170503053511_bib39","doi-asserted-by":"crossref","first-page":"R34","DOI":"10.1186\/bcr1682","article-title":"Association of TP53 codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients","volume":"9","author":"Toyama","year":"2007","journal-title":"Breast Cancer Res."},{"key":"key\n\t\t\t\t20170503053511_bib40","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1128\/MCB.23.16.5867-5881.2003","article-title":"Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression","volume":"23","author":"Kinyamu","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170503053511_bib41","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1128\/MCB.19.1.864","article-title":"Regulation of the mdm2 oncogene by thyroid hormone receptor","volume":"19","author":"Qi","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170503053511_bib42","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10549-006-9407-5","article-title":"MDM2 SNP309 accelerates familial breast carcinogenesis independently of estrogen signaling","volume":"104","author":"Wasielewski","year":"2007","journal-title":"Breast Cancer Res. Treat."},{"key":"key\n\t\t\t\t20170503053511_bib43","first-page":"4975","article-title":"Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk","volume":"26","author":"Petenkaya","year":"2006","journal-title":"Anticancer Res."},{"key":"key\n\t\t\t\t20170503053511_bib44","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1158\/1078-0432.CCR-06-2281","article-title":"MDM2 promoter SNP309 is associated with risk of occurrence and advanced lymph node metastasis of nasopharyngeal carcinoma in Chinese population","volume":"13","author":"Zhou","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"key\n\t\t\t\t20170503053511_bib45","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1200\/JCO.2005.04.1459","article-title":"MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis","volume":"24","author":"Ohmiya","year":"2006","journal-title":"J. Clin. Oncol."}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/29\/4\/754\/14132247\/bgn024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T01:36:07Z","timestamp":1503624967000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article-lookup\/doi\/10.1093\/carcin\/bgn024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,14]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,2,14]]},"published-print":{"date-parts":[[2008,4]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgn024","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2,14]]}}}