{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:39:51Z","timestamp":1784979591705,"version":"3.55.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1093\/carcin\/bgs372","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T01:35:58Z","timestamp":1354066558000},"page":"595-604","source":"Crossref","is-referenced-by-count":69,"title":["Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma"],"prefix":"10.1093","volume":"34","author":[{"given":"Yulin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhou","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouzhi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,11,27]]},"reference":[{"key":"key\n\t\t\t\t20170521010103_CIT0001","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA. Cancer J. Clin"},{"key":"key\n\t\t\t\t20170521010103_CIT0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta11340","article-title":"Surveillance of cirrhosis for hepatocellular carcinoma: systematic review and economic analysis","volume":"11","author":"Thompson Coon","year":"2007","journal-title":"Health Technol. Assess"},{"key":"key\n\t\t\t\t20170521010103_CIT0003","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra1001683","article-title":"Hepatocellular carcinoma","volume":"365","author":"El-Serag","year":"2011","journal-title":"N. Engl. J. Med"},{"key":"key\n\t\t\t\t20170521010103_CIT0004","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.dld.2004.11.005","article-title":"Screening for hepatocellular carcinoma","volume":"37","author":"De Masi","year":"2005","journal-title":"Dig. Liver Dis"},{"key":"key\n\t\t\t\t20170521010103_CIT0005","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1053\/j.gastro.2009.04.005","article-title":"Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma","volume":"137","author":"Marrero","year":"2009","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170521010103_CIT0006","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1007\/s10620-010-1184-7","article-title":"Serum markers of hepatocellular carcinoma","volume":"55","author":"Malaguarnera","year":"2010","journal-title":"Dig. Dis. Sci"},{"key":"key\n\t\t\t\t20170521010103_CIT0007","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/j.seminoncol.2010.05.007","article-title":"Molecular markers for early detection","volume":"37","author":"Dunn","year":"2010","journal-title":"Semin. Oncol"},{"key":"key\n\t\t\t\t20170521010103_CIT0008","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/S0016-5085(86)80025-7","article-title":"A new method to assay des-gamma-carboxyprothrombin. Results obtained in 75 cases of hepatocellular carcinoma","volume":"91","author":"Soulier","year":"1986","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170521010103_CIT0009","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0021-9673(92)85532-X","article-title":"Lectin affinity electrophoresis of alpha-fetoprotein. Increased specificity and sensitivity as a marker of hepatocellular carcinoma","volume":"604","author":"Hirai","year":"1992","journal-title":"J. Chromatogr"},{"key":"key\n\t\t\t\t20170521010103_CIT0010","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1053\/j.gastro.2009.10.031","article-title":"Des-gamma-carboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma","volume":"138","author":"Lok","year":"2010","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170521010103_CIT0011","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.2174\/138161207782794167","article-title":"The role of annexin II in angiogenesis and tumor progression: a potential therapeutic target","volume":"13","author":"Sharma","year":"2007","journal-title":"Curr. Pharm. Des"},{"key":"key\n\t\t\t\t20170521010103_CIT0012","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12307-011-0064-9","article-title":"The role of annexin A2 in tumorigenesis and cancer progression","volume":"4","author":"Lokman","year":"2011","journal-title":"Cancer Microenviron"},{"key":"key\n\t\t\t\t20170521010103_CIT0013","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.vph.2011.03.003","article-title":"The annexin A2 system and vascular homeostasis","volume":"54","author":"Flood","year":"2011","journal-title":"Vascul. Pharmacol"},{"key":"key\n\t\t\t\t20170521010103_CIT0014","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1152\/physrev.00030.2001","article-title":"Annexins: from structure to function","volume":"82","author":"Gerke","year":"2002","journal-title":"Physiol. Rev"},{"key":"key\n\t\t\t\t20170521010103_CIT0015","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/09687688.2012.693210","article-title":"Do annexins participate in lipid messenger mediated intracellular signaling? A question revisited","volume":"29","author":"Bandorowicz-Pikula","year":"2012","journal-title":"Mol. Membr. Biol"},{"issue":"2B","key":"key\n\t\t\t\t20170521010103_CIT0016","first-page":"1339","article-title":"Annexin II overexpression is correlated with poor prognosis in human gastric carcinoma","volume":"21","author":"Emoto","year":"2001","journal-title":"Anticancer Res"},{"key":"key\n\t\t\t\t20170521010103_CIT0017","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/jcb.21727","article-title":"Proteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinoma","volume":"104","author":"Qi","year":"2008","journal-title":"J. Cell. Biochem"},{"key":"key\n\t\t\t\t20170521010103_CIT0018","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1021\/pr800152u","article-title":"Proteome analysis of membrane fractions in colorectal carcinomas by using 2D-DIGE saturation labeling","volume":"7","author":"Alfonso","year":"2008","journal-title":"J. Proteome Res"},{"key":"key\n\t\t\t\t20170521010103_CIT0019","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.lungcan.2008.10.024","article-title":"Identification of metastasis associated proteins in human lung squamous carcinoma using two-dimensional difference gel electrophoresis and laser capture microdissection","volume":"65","author":"Yao","year":"2009","journal-title":"Lung Cancer"},{"key":"key\n\t\t\t\t20170521010103_CIT0020","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.yexmp.2006.03.003","article-title":"Angiogenesis-associated protein annexin II in breast cancer: selective expression in invasive breast cancer and contribution to tumor invasion and progression","volume":"81","author":"Sharma","year":"2006","journal-title":"Exp. Mol. Pathol"},{"key":"key\n\t\t\t\t20170521010103_CIT0021","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1002\/hep.24592","article-title":"HAb18G\/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells","volume":"54","author":"Zhao","year":"2011","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170521010103_CIT0022","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.bbamcr.2006.08.043","article-title":"Annexin A2 recognises a specific region in the 3\u2019-UTR of its cognate messenger RNA","volume":"1763","author":"Holl\u00e5s","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170521010103_CIT0023","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s004180050275","article-title":"Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study","volume":"110","author":"Dreier","year":"1998","journal-title":"Histochem. Cell Biol"},{"key":"key\n\t\t\t\t20170521010103_CIT0024","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/emm.2007.70","article-title":"Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma","volume":"39","author":"Yu","year":"2007","journal-title":"Exp. Mol. Med"},{"key":"key\n\t\t\t\t20170521010103_CIT0025","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.ejca.2008.02.019","article-title":"Molecular mapping of human hepatocellular carcinoma provides deeper biological insight from genomic data","volume":"44","author":"Kittaka","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"key\n\t\t\t\t20170521010103_CIT0026","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1006\/bbrc.2002.6547","article-title":"Proteome analysis of hepatocellular carcinoma","volume":"291","author":"Lim","year":"2002","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"key\n\t\t\t\t20170521010103_CIT0027","first-page":"1157","article-title":"Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma","volume":"33","author":"Mohammad","year":"2008","journal-title":"Int. J. Oncol"},{"key":"key\n\t\t\t\t20170521010103_CIT0028","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1128\/MCB.10.6.3216","article-title":"Enhanced expression of the protein kinase substrate p36 in human hepatocellular carcinoma","volume":"10","author":"Frohlich","year":"1990","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20170521010103_CIT0029","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.prp.2010.09.007","article-title":"Annexin A2 as a differential diagnostic marker of hepatocellular tumors","volume":"207","author":"Longerich","year":"2011","journal-title":"Pathol. Res. Pract"},{"key":"key\n\t\t\t\t20170521010103_CIT0030","first-page":"765","article-title":"Evaluation of annexin II as a potential serum marker for hepatocellular carcinoma using a developed sandwich ELISA method","volume":"24","author":"Ji","year":"2009","journal-title":"Int. J. Mol. Med"},{"key":"key\n\t\t\t\t20170521010103_CIT0031","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1021\/pr800153s","article-title":"Quantitative proteomic signature of liver cancer cells: tissue transglutaminase 2 could be a novel protein candidate of human hepatocellular carcinoma","volume":"7","author":"Sun","year":"2008","journal-title":"J. Proteome Res"},{"key":"key\n\t\t\t\t20170521010103_CIT0032","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1002\/pmic.200401226","article-title":"Comparison of alternative analytical techniques for the characterisation of the human serum proteome in HUPO Plasma Proteome Project","volume":"5","author":"Li","year":"2005","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20170521010103_CIT0033","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E","article-title":"Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies","volume":"7","author":"Edmondson","year":"1954","journal-title":"Cancer"},{"key":"key\n\t\t\t\t20170521010103_CIT0034","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/nprot.2007.160","article-title":"Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion","volume":"2","author":"Hilpert","year":"2007","journal-title":"Nat. Protoc"},{"key":"key\n\t\t\t\t20170521010103_CIT0035","first-page":"8085","article-title":"Beta-catenin expression is altered in human colonic aberrant crypt foci","volume":"61","author":"Hao","year":"2001","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170521010103_CIT0036","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/hep.20076","article-title":"HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice","volume":"39","author":"Wang","year":"2004","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170521010103_CIT0037","first-page":"315","article-title":"Gene expression profiling of human HBV- and\/or HCV-associated hepatocellular carcinoma cells using expressed sequence tags","volume":"29","author":"Yoon","year":"2006","journal-title":"Int. J. Oncol"},{"key":"key\n\t\t\t\t20170521010103_CIT0038","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.jprot.2009.12.004","article-title":"Protein profile in HBx transfected cells: a comparative iTRAQ-coupled 2D LC-MS\/MS analysis","volume":"73","author":"Feng","year":"2010","journal-title":"J. Proteomics"},{"key":"key\n\t\t\t\t20170521010103_CIT0039","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1073\/pnas.82.23.7884","article-title":"Amino-terminal sequence of p36 and associated p10: identification of the site of tyrosine phosphorylation and homology with S-100","volume":"82","author":"Glenney","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20170521010103_CIT0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1990.tb15363.x","article-title":"Structural analysis of p36, a Ca2+\/lipid-binding protein of the annexin family, by proteolysis and chemical fragmentation","volume":"188","author":"Johnsson","year":"1990","journal-title":"Eur. J. Biochem"},{"key":"key\n\t\t\t\t20170521010103_CIT0041","doi-asserted-by":"crossref","first-page":"21191","DOI":"10.1016\/S0021-9258(17)31947-6","article-title":"An endothelial cell receptor for plasminogen\/tissue plasminogen activator. I. Identity with annexin II","volume":"269","author":"Hajjar","year":"1994","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20170521010103_CIT0042","doi-asserted-by":"crossref","first-page":"16958","DOI":"10.1021\/bi981713l","article-title":"The p11 subunit of the annexin II tetramer plays a key role in the stimulation of t-PA-dependent plasminogen activation","volume":"37","author":"Kassam","year":"1998","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170521010103_CIT0043","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1111\/j.1742-4658.2008.06620.x","article-title":"Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces","volume":"275","author":"Tsunezumi","year":"2008","journal-title":"FEBS J"},{"key":"key\n\t\t\t\t20170521010103_CIT0044","doi-asserted-by":"crossref","first-page":"33329","DOI":"10.1074\/jbc.M005655200","article-title":"Selective degradation of annexins by chaperone-mediated autophagy","volume":"275","author":"Cuervo","year":"2000","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20170521010103_CIT0045","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1091\/mbc.E09-02-0174","article-title":"Glycogen synthase kinase-3 and Omi\/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis","volume":"20","author":"Wang","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"key\n\t\t\t\t20170521010103_CIT0046","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1096\/fj.02-0070com","article-title":"Modulating signaling events in smooth muscle: cleavage of annexin 2 abolishes its binding to lipid rafts","volume":"16","author":"Babiychuk","year":"2002","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170521010103_CIT0047","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1158\/1078-0432.CCR-03-0321","article-title":"Identification of altered protein expression and post-translational modifications in primary colorectal cancer by using agarose two-dimensional gel electrophoresis","volume":"10","author":"Tomonaga","year":"2004","journal-title":"Clin. Cancer Res"},{"key":"key\n\t\t\t\t20170521010103_CIT0048","doi-asserted-by":"crossref","first-page":"W168","DOI":"10.1093\/nar\/gki460","article-title":"CEP: a conformational epitope prediction server","volume":"33","author":"Kulkarni-Kale","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170521010103_CIT0049","first-page":"1267","article-title":"Tissue remodelling in liver diseases","volume":"18","author":"Giannelli","year":"2003","journal-title":"Histol. Histopathol"},{"key":"key\n\t\t\t\t20170521010103_CIT0050","article-title":"Extracellular matrix remodeling: the common denominator in connective tissue diseases possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure","author":"Karsdal","year":"2012","journal-title":"Assay and drug development technologies"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/34\/3\/595\/17292307\/bgs372.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T12:45:22Z","timestamp":1643719522000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article-lookup\/doi\/10.1093\/carcin\/bgs372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,27]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,11,27]]},"published-print":{"date-parts":[[2013,3]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgs372","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11,27]]}}}