{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:08:24Z","timestamp":1789992504457,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1093\/carcin\/bgt102","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T01:23:25Z","timestamp":1364433805000},"page":"1660-1668","source":"Crossref","is-referenced-by-count":24,"title":["Undifferentiated embryonic cell transcription factor-1 (UTF1) inhibits the growth of cervical cancer cells by transactivating p27Kip1"],"prefix":"10.1093","volume":"34","author":[{"given":"Xiao-Ling","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Sheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,27]]},"reference":[{"key":"key\n\t\t\t\t20170520220757_CIT0001","article-title":"Globocan 2008 cancer fact sheet","author":"Dataname","year":"2013"},{"key":"key\n\t\t\t\t20170520220757_CIT0002","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S1201-9712(07)60015-0","article-title":"Human papillomavirus infection and the development of cervical cancer and related genital neoplasias","volume":"11","author":"Paavonen","year":"2007","journal-title":"Int. J. Infect. Dis."},{"key":"key\n\t\t\t\t20170520220757_CIT0003","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3109\/09513590.2011.558953","article-title":"Smoking habit, immune suppression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis: a review of the literature","volume":"27","author":"Gadducci","year":"2011","journal-title":"Gynecol. Endocrinol."},{"key":"key\n\t\t\t\t20170520220757_CIT0004","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2105\/AJPH.91.6.947","article-title":"Papanicolaou test screening and prevalence of genital human papillomavirus among women who have sex with women","volume":"91","author":"Marrazzo","year":"2001","journal-title":"Am. J. Public Health"},{"key":"key\n\t\t\t\t20170520220757_CIT0005","first-page":"167","article-title":"Host cell responses to genotypically similar Helicobacter pylori isolates from United States and Japan","volume":"9","author":"Ando","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"key\n\t\t\t\t20170520220757_CIT0006","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.humpath.2009.11.021","article-title":"Expression of Sox2 in human cervical carcinogenesis","volume":"41","author":"Ji","year":"2010","journal-title":"Hum. Pathol."},{"key":"key\n\t\t\t\t20170520220757_CIT0007","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/sj.bjc.6603597","article-title":"Stat3 activation in human endometrial and cervical cancers","volume":"96","author":"Chen","year":"2007","journal-title":"Br. J. Cancer"},{"key":"key\n\t\t\t\t20170520220757_CIT0008","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-2407-8-108","article-title":"Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells","volume":"8","author":"Ye","year":"2008","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t20170520220757_CIT0009","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/S0002-9440(10)61143-1","article-title":"Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis","volume":"160","author":"Steenbergen","year":"2002","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170520220757_CIT0010","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1093\/emboj\/17.7.2019","article-title":"UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells","volume":"17","author":"Okuda","year":"1998","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170520220757_CIT0011","doi-asserted-by":"crossref","first-page":"25840","DOI":"10.1074\/jbc.273.40.25840","article-title":"Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity","volume":"273","author":"Fukushima","year":"1998","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170520220757_CIT0012","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1006\/bbrc.2001.5265","article-title":"Structural analyses of the UTF1 gene encoding a transcriptional coactivator expressed in pluripotent embryonic stem cells","volume":"285","author":"Nishimoto","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170520220757_CIT0013","doi-asserted-by":"crossref","first-page":"e118","DOI":"10.1093\/nar\/gkm704","article-title":"A UTF1-based selection system for stable homogeneously pluripotent human embryonic stem cell cultures","volume":"35","author":"Tan","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170520220757_CIT0014","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1083\/jcb.200702058","article-title":"UTF1 is a chromatin-associated protein involved in ES cell differentiation","volume":"178","author":"van den Boom","year":"2007","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170520220757_CIT0015","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.scr.2009.02.001","article-title":"Characterization of human UTF1, a chromatin-associated protein with repressor activity expressed in pluripotent cells","volume":"2","author":"Kooistra","year":"2009","journal-title":"Stem Cell Res."},{"key":"key\n\t\t\t\t20170520220757_CIT0016","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.1128\/MCB.25.12.5084-5094.2005","article-title":"Oct-3\/4 maintains the proliferative embryonic stem cell state via specific binding to a variant octamer sequence in the regulatory region of the UTF1 locus","volume":"25","author":"Nishimoto","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170520220757_CIT0017","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1006\/bbrc.1999.0673","article-title":"Carboxy-terminally truncated form of a coactivator UTF1 stimulates transcription from a variety of gene promoters through the TATA Box","volume":"258","author":"Fukushima","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170520220757_CIT0018","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.stem.2008.10.002","article-title":"Two supporting factors greatly improve the efficiency of human iPSC generation","volume":"3","author":"Zhao","year":"2008","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20170520220757_CIT0019","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1600-0749.2007.00414.x","article-title":"ATF2 on the double - activating transcription factor and DNA damage response protein","volume":"20","author":"Bhoumik","year":"2007","journal-title":"Pigment Cell Res."},{"key":"key\n\t\t\t\t20170520220757_CIT0020","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/molehr\/gaq008","article-title":"OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres","volume":"16","author":"Kristensen","year":"2010","journal-title":"Mol. Hum. Reprod."},{"key":"key\n\t\t\t\t20170520220757_CIT0021","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2119\/molmed.2009.00068","article-title":"Expression pattern of stemness-related genes in human endometrial and endometriotic tissues","volume":"15","author":"Forte","year":"2009","journal-title":"Mol. Med."},{"key":"key\n\t\t\t\t20170520220757_CIT0022","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1309\/AJCPB44HBKINJNYU","article-title":"Expression of UTF1 in primary and metastatic testicular germ cell tumors","volume":"134","author":"Wang","year":"2010","journal-title":"Am. J. Clin. Pathol."},{"key":"key\n\t\t\t\t20170520220757_CIT0023","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/PAS.0b013e3181db84aa","article-title":"Diagnostic utility of novel stem cell markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in primary mediastinal germ cell tumors","volume":"34","author":"Liu","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"key\n\t\t\t\t20170520220757_CIT0024","doi-asserted-by":"crossref","first-page":"e42704","DOI":"10.1371\/journal.pone.0042704","article-title":"Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis","volume":"7","author":"Guenin","year":"2012","journal-title":"PLoS One."},{"key":"key\n\t\t\t\t20170520220757_CIT0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(97)00660-1","article-title":"Molecular cloning and characterization of the human p27Kip1 gene promoter","volume":"411","author":"Minami","year":"1997","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170520220757_CIT0026","doi-asserted-by":"crossref","first-page":"217","DOI":"10.18553\/jmcp.2010.16.3.217","article-title":"Prophylaxis of cervical cancer and related cervical disease: a review of the cost-effectiveness of vaccination against oncogenic HPV types","volume":"16","author":"Armstrong","year":"2010","journal-title":"J. Manag. Care Pharm."},{"key":"key\n\t\t\t\t20170520220757_CIT0027","doi-asserted-by":"crossref","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t20170520220757_CIT0028","article-title":"Cervical cancer tumorigenesis","author":"GEO"},{"key":"key\n\t\t\t\t20170520220757_CIT0029","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/sj.bjc.6604193","article-title":"SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis","volume":"98","author":"Otsubo","year":"2008","journal-title":"Br. J. Cancer"},{"key":"key\n\t\t\t\t20170520220757_CIT0030","first-page":"257","article-title":"Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma","volume":"24","author":"Li","year":"2004","journal-title":"Int. J. Oncol."},{"key":"key\n\t\t\t\t20170520220757_CIT0031","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0006-291X(03)01356-1","article-title":"Downregulation and growth inhibitory effect of epithelial-type Kr\u00fcppel-like transcription factor KLF4, but not KLF5, in bladder cancer","volume":"308","author":"Ohnishi","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170520220757_CIT0032","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1158\/0008-5472.CAN-07-5953","article-title":"Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells","volume":"68","author":"Wei","year":"2008","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170520220757_CIT0033","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/sj.onc.1207067","article-title":"Identification of Kr\u00fcppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer","volume":"23","author":"Zhao","year":"2004","journal-title":"Oncogene."},{"key":"key\n\t\t\t\t20170520220757_CIT0034","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.1128\/MCB.19.8.5453","article-title":"The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3\/4 and Sox-2","volume":"19","author":"Nishimoto","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170520220757_CIT0035","doi-asserted-by":"crossref","first-page":"e9580","DOI":"10.1371\/journal.pone.0009580","article-title":"Initial colony morphology-based selection for iPS cells derived from adult fibroblasts is substantially improved by temporary UTF1-based selection","volume":"5","author":"Pfannkuche","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170520220757_CIT0036","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1093\/humrep\/deq053","article-title":"Screening for biomarkers of spermatogonia within the human testis: a whole genome approach","volume":"25","author":"von Kopylow","year":"2010","journal-title":"Hum. Reprod."},{"key":"key\n\t\t\t\t20170520220757_CIT0037","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/humrep\/den010","article-title":"Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms","volume":"23","author":"Kristensen","year":"2008","journal-title":"Hum. Reprod."},{"key":"key\n\t\t\t\t20170520220757_CIT0038","article-title":"Genes that prevent and cause cancer: tumor suppressor genes and oncogenes.","author":"Madhani"},{"key":"key\n\t\t\t\t20170520220757_CIT0039","article-title":"Oncogenes, tumor suppressor genes, and cancer","journal-title":"American Cancer Society."},{"key":"key\n\t\t\t\t20170520220757_CIT0040","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMra023075","article-title":"Gene silencing in cancer in association with promoter hypermethylation","volume":"349","author":"Herman","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170520220757_CIT0041","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00432-011-0994-0","article-title":"Aberrant promoter methylation and inactivation of PTEN gene in cervical carcinoma from Indian population","volume":"137","author":"Rizvi","year":"2011","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"key\n\t\t\t\t20170520220757_CIT0042","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0959-8049(02)00175-2","article-title":"E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours","volume":"39","author":"Chen","year":"2003","journal-title":"Eur. J. Cancer"},{"key":"key\n\t\t\t\t20170520220757_CIT0043","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4161\/epi.6.6.16216","article-title":"Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis","volume":"6","author":"Sartor","year":"2011","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t20170520220757_CIT0044","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/carcin\/21.3.485","article-title":"Apoptosis in cancer","volume":"21","author":"Lowe","year":"2000","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170520220757_CIT0045","first-page":"3689","article-title":"The Pezcoller lecture: cancer cell cycles revisited","volume":"60","author":"Sherr","year":"2000","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170520220757_CIT0046","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s10654-012-9746-y","article-title":"Cancer mortality patterns among Turkish immigrants in four European countries and in Turkey","volume":"27","author":"Spallek","year":"2012","journal-title":"Eur. J. Epidemiol."},{"key":"key\n\t\t\t\t20170520220757_CIT0047","article-title":"The epidemiology of thyroid cancer in the Czech Republic in comparison with other countries","volume":"156","author":"Lukas","year":"2012","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub."},{"key":"key\n\t\t\t\t20170520220757_CIT0048","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1038\/sj.onc.1205461","article-title":"BRCA1 transactivates the cyclin-dependent kinase inhibitor p27(Kip1)","volume":"21","author":"Williamson","year":"2002","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170520220757_CIT0049","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1083\/jcb.142.2.557","article-title":"E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1)","volume":"142","author":"St Croix","year":"1998","journal-title":"J. Cell Biol."}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/34\/7\/1660\/17296518\/bgt102.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T15:12:56Z","timestamp":1644678776000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article-lookup\/doi\/10.1093\/carcin\/bgt102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,27]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,3,27]]},"published-print":{"date-parts":[[2013,7]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgt102","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3,27]]}}}