{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:10:06Z","timestamp":1791173406417,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1093\/carcin\/bgt137","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T23:53:06Z","timestamp":1366847586000},"page":"1918-1928","source":"Crossref","is-referenced-by-count":92,"title":["Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation"],"prefix":"10.1093","volume":"34","author":[{"given":"Mi Jin","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Jung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Ahn","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Hee","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeg Kyu","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Sook","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,6,3]]},"reference":[{"key":"key\n\t\t\t\t20170521002517_CIT0001","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1172\/JCI6926","article-title":"Safety and antitumor activity of recombinant soluble Apo2 ligand","volume":"104","author":"Ashkenazi","year":"1999","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170521002517_CIT0002","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0083-6729(04)67022-1","article-title":"TRAIL and malignant glioma","volume":"67","author":"Hawkins","year":"2004","journal-title":"Vitam. Horm."},{"key":"key\n\t\t\t\t20170521002517_CIT0003","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1158\/1541-7786.MCR-09-0244","article-title":"Repeated treatment with subtoxic doses of TRAIL induces resistance to apoptosis through its death receptors in MDA-MB-231 breast cancer cells","volume":"7","author":"Yoshida","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"key\n\t\t\t\t20170521002517_CIT0004","first-page":"338","article-title":"Glioblastoma: therapeutic challenges, what lies ahead","volume":"1826","author":"Lima","year":"2012","journal-title":"Biochim. Biophys. Acta."},{"key":"key\n\t\t\t\t20170521002517_CIT0005","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1038\/sj.onc.1204810","article-title":"Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells","volume":"20","author":"Knight","year":"2001","journal-title":"Oncogene."},{"key":"key\n\t\t\t\t20170521002517_CIT0006","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1128\/CMR.16.2.175-188.2003","article-title":"Antimicrobial growth promoters used in animal feed: effects of less well known antibiotics on gram-positive bacteria","volume":"16","author":"Butaye","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"key\n\t\t\t\t20170521002517_CIT0007","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.bi.45.070176.002441","article-title":"Biological applications of ionophores","volume":"45","author":"Pressman","year":"1976","journal-title":"Annu. Rev. Biochem."},{"key":"key\n\t\t\t\t20170521002517_CIT0008","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/hlca.19710540419","article-title":"Crystal structure of the antibiotic monensin similarities and differences between free acid and metal complex","volume":"54","author":"Lutz","year":"1971","journal-title":"Helv. Chim. Acta."},{"key":"key\n\t\t\t\t20170521002517_CIT0009","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-1-4684-3279-4_14","article-title":"Biological applications and evolutionary origins of ionophores","volume":"84","author":"Pressman","year":"1977","journal-title":"Adv. Exp. Med. Biol."},{"key":"key\n\t\t\t\t20170521002517_CIT0010","first-page":"406","article-title":"Preliminary studies on lasalocid toxicosis in cattle","volume":"24","author":"Galitzer","year":"1982","journal-title":"Vet. Hum. Toxicol."},{"key":"key\n\t\t\t\t20170521002517_CIT0011","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/ijc.20959","article-title":"Na+\/H+ exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin","volume":"115","author":"Miraglia","year":"2005","journal-title":"Int. J. Cancer."},{"key":"key\n\t\t\t\t20170521002517_CIT0012","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.bbrc.2010.03.138","article-title":"Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells","volume":"394","author":"Fuchs","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170521002517_CIT0013","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bcmd.2010.03.008","article-title":"The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor","volume":"45","author":"Riccioni","year":"2010","journal-title":"Blood Cells. Mol. Dis."},{"key":"key\n\t\t\t\t20170521002517_CIT0014","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2009.06.034","article-title":"Identification of selective inhibitors of cancer stem cells by high-throughput screening","volume":"138","author":"Gupta","year":"2009","journal-title":"Cell."},{"key":"key\n\t\t\t\t20170521002517_CIT0015","doi-asserted-by":"crossref","first-page":"7002","DOI":"10.1016\/j.bmcl.2012.09.046","article-title":"Polyether ionophores-promising bioactive molecules for cancer therapy","volume":"22","author":"Huczy\u0144ski","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"key\n\t\t\t\t20170521002517_CIT0016","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/jnr.490150303","article-title":"Neuroimmunology of gangliosides in human neurons and glial cells in culture","volume":"15","author":"Kim","year":"1986","journal-title":"J. Neurosci. Res."},{"key":"key\n\t\t\t\t20170521002517_CIT0017","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv. Enzyme Regul."},{"key":"key\n\t\t\t\t20170521002517_CIT0018","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/S0006-2952(97)00003-8","article-title":"The multidrug-resistant human lung tumour cell line, DLKP-A10, expresses novel drug accumulation and sequestration systems","volume":"53","author":"Cleary","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"key\n\t\t\t\t20170521002517_CIT0019","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0014-4827(83)90377-4","article-title":"Effect of carboxylic ionophores on lysosomal protein degradation in rat hepatocytes","volume":"149","author":"Grinde","year":"1983","journal-title":"Exp. Cell Res."},{"key":"key\n\t\t\t\t20170521002517_CIT0020","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1128\/MCB.25.3.1025-1040.2005","article-title":"Inhibition of macroautophagy triggers apoptosis","volume":"25","author":"Boya","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170521002517_CIT0021","doi-asserted-by":"crossref","first-page":"17707","DOI":"10.1016\/S0021-9258(19)47429-2","article-title":"Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells","volume":"266","author":"Yoshimori","year":"1991","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170521002517_CIT0022","first-page":"468","article-title":"Effects of lysosomotropic monoamines, diamines, amino alcohols, and other amino compounds on protein degradation and protein synthesis in isolated rat hepatocytes","volume":"18","author":"Seglen","year":"1980","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170521002517_CIT0023","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.4161\/auto.6826","article-title":"Selective turnover of p62\/A170\/SQSTM1 by autophagy","volume":"4","author":"Ichimura","year":"2008","journal-title":"Autophagy."},{"key":"key\n\t\t\t\t20170521002517_CIT0024","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.molcel.2009.01.020","article-title":"A role for NBR1 in autophagosomal degradation of ubiquitinated substrates","volume":"33","author":"Kirkin","year":"2009","journal-title":"Mol. Cell."},{"key":"key\n\t\t\t\t20170521002517_CIT0025","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1679\/aohc.64.233","article-title":"Autophagic cell death and its execution by lysosomal cathepsins","volume":"64","author":"Uchiyama","year":"2001","journal-title":"Arch. Histol. Cytol."},{"key":"key\n\t\t\t\t20170521002517_CIT0026","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s004180050256","article-title":"Golgi-disturbing agents","volume":"109","author":"Dinter","year":"1998","journal-title":"Histochem. Cell Biol."},{"key":"key\n\t\t\t\t20170521002517_CIT0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1247\/csf.10014","article-title":"Novel cis-acting element GASE regulates transcriptional induction by the Golgi stress response","volume":"36","author":"Oku","year":"2011","journal-title":"Cell Struct. Funct."},{"key":"key\n\t\t\t\t20170521002517_CIT0028","doi-asserted-by":"crossref","first-page":"H1411","DOI":"10.1152\/ajpheart.01378.2005","article-title":"Activation of endoplasmic reticulum stress response during the development of ischemic heart disease","volume":"291","author":"Azfer","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"key\n\t\t\t\t20170521002517_CIT0029","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/sj.cdd.4401187","article-title":"Apo2L\/TRAIL and its death and decoy receptors","volume":"10","author":"LeBlanc","year":"2003","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170521002517_CIT0030","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1093\/carcin\/bgm173","article-title":"Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response","volume":"28","author":"Chen","year":"2007","journal-title":"Carcinogenesis."},{"key":"key\n\t\t\t\t20170521002517_CIT0031","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1158\/0008-5472.CAN-05-0312","article-title":"Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells","volume":"65","author":"Shiraishi","year":"2005","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170521002517_CIT0032","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1038\/sj.onc.1204673","article-title":"Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells","volume":"20","author":"Fukazawa","year":"2001","journal-title":"Oncogene."},{"key":"key\n\t\t\t\t20170521002517_CIT0033","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev.pa.22.040182.002341","article-title":"Pharmacology and toxicology of the monovalent carboxylic ionophores","volume":"22","author":"Pressman","year":"1982","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"key\n\t\t\t\t20170521002517_CIT0034","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3382\/ps.2010-00931","article-title":"Forty years of monensin for the control of poultry","volume":"89","author":"Vhapman","year":"2010","journal-title":"Poult. Sci."},{"key":"key\n\t\t\t\t20170521002517_CIT0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/bjc.2011.530","article-title":"Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress","volume":"106","author":"Ketola","year":"2012","journal-title":"Br. J. Cancer."},{"key":"key\n\t\t\t\t20170521002517_CIT0036","doi-asserted-by":"crossref","first-page":"13253","DOI":"10.1073\/pnas.1110431108","article-title":"Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells","volume":"108","author":"Lu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170521002517_CIT0037","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1124\/mol.110.064790","article-title":"Pharmacological targeting of constitutively active truncated androgen receptor by nigericin and suppression of hormone-refractory prostate cancer cell growth","volume":"78","author":"Mashima","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170521002517_CIT0038","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1155\/MBD.1994.175","article-title":"Analysis of multidrug transporter in living cells. Inhibition of P-glycoprotein-mediated efflux of anthracyclines by ionophores","volume":"1","author":"Borrel","year":"1994","journal-title":"Met. Based. Drugs."},{"key":"key\n\t\t\t\t20170521002517_CIT0039","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/stem.769","article-title":"Concise review: cancer stem cells and minimal residual disease","volume":"30","author":"Ghiaur","year":"2012","journal-title":"Stem Cells."},{"key":"key\n\t\t\t\t20170521002517_CIT0040","doi-asserted-by":"crossref","first-page":"6015","DOI":"10.1016\/S0021-9258(18)38074-8","article-title":"Analysis of the retention signals of two resident luminal endoplasmic reticulum proteins by in vitro mutagenesis","volume":"266","author":"Haugejorden","year":"1991","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170521002517_CIT0041","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","article-title":"Roles of CHOP\/GADD153 in endoplasmic reticulum stress","volume":"11","author":"Oyadomari","year":"2004","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170521002517_CIT0042","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/sj.cdd.4401378","article-title":"Coupling endoplasmic reticulum stress to the cell death program","volume":"11","author":"Rao","year":"2004","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170521002517_CIT0043","doi-asserted-by":"crossref","first-page":"8274","DOI":"10.1158\/0008-5472.CAN-07-0407","article-title":"Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin","volume":"67","author":"Son","year":"2007","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170521002517_CIT0044","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1158\/0008-5472.CAN-07-2444","article-title":"Arsenic trioxide sensitizes human glioma cells, but not normal astrocytes, to TRAIL-induced apoptosis via CCAAT\/enhancer-binding protein homologous protein-dependent DR5 up-regulation","volume":"68","author":"Kim","year":"2008","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170521002517_CIT0045","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0076-6879(83)98138-7","article-title":"Perturbation of the structure and function of the Golgi complex by monovalent carboxylic ionophores","volume":"98","author":"Tartakoff","year":"1983","journal-title":"Methods Enzymol."},{"key":"key\n\t\t\t\t20170521002517_CIT0046","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.116.5.1071","article-title":"Brefeldin A: insights into the control of membrane traffic and organelle structure","volume":"116","author":"Klausner","year":"1992","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170521002517_CIT0047","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11010-008-9893-3","article-title":"Brefeldin A activates CHOP promoter at the AARE, ERSE and AP-1 elements","volume":"319","author":"Kwok","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"key\n\t\t\t\t20170521002517_CIT0048","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/40657","article-title":"Inhibition of death receptor signals by cellular FLIP","volume":"388","author":"Irmler","year":"1997","journal-title":"Nature."},{"key":"key\n\t\t\t\t20170521002517_CIT0049","doi-asserted-by":"crossref","first-page":"652","DOI":"10.4161\/cbt.315","article-title":"Role of MRIT\/cFLIP in protection against chemotherapy-induced apoptosis","volume":"1","author":"Matta","year":"2002","journal-title":"Cancer Biol. Ther."}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/34\/8\/1918\/17294194\/bgt137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T14:39:17Z","timestamp":1644849557000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article-lookup\/doi\/10.1093\/carcin\/bgt137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,3]]},"references-count":49,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,6,3]]},"published-print":{"date-parts":[[2013,8]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgt137","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6,3]]}}}