{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:28:58Z","timestamp":1791332938002,"version":"4.3.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1093\/carcin\/bgt144","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T17:16:14Z","timestamp":1367428574000},"page":"2129-2136","source":"Crossref","is-referenced-by-count":9,"title":["p53 dysfunction precedes the activation of nuclear factor-\u03baB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein"],"prefix":"10.1093","volume":"34","author":[{"given":"Takeo","family":"Ohsugi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Shimasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Umezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"key\n\t\t\t\t20170521010645_CIT0001","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","article-title":"Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma","volume":"77","author":"Poiesz","year":"1980","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170521010645_CIT0002","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1073\/pnas.78.10.6476","article-title":"Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera","volume":"78","author":"Hinuma","year":"1981","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170521010645_CIT0003","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1038\/sj.onc.1208978","article-title":"Molecular mechanisms of cellular transformation by HTLV-1 Tax","volume":"24","author":"Grassmann","year":"2005","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170521010645_CIT0004","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrc2111","article-title":"Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation","volume":"7","author":"Matsuoka","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20170521010645_CIT0005","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S1473-3099(07)70081-6","article-title":"Human T-lymphotropic virus 1: recent knowledge about an ancient infection","volume":"7","author":"Verdonck","year":"2007","journal-title":"Lancet Infect. Dis"},{"key":"key\n\t\t\t\t20170521010645_CIT0006","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0925-5710(97)00077-7","article-title":"HTLV-1-associated diseases","volume":"66","author":"Watanabe","year":"1997","journal-title":"Int. J. Hematol"},{"key":"key\n\t\t\t\t20170521010645_CIT0007","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nrc864","article-title":"Live or let die: the cell\u2019s response to p53","volume":"2","author":"Vousden","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20170521010645_CIT0008","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/carcin\/bgi274","article-title":"Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications","volume":"27","author":"Tabakin-Fix","year":"2006","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170521010645_CIT0009","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1038\/sj.onc.1208969","article-title":"Activation of NF-\u03baB by HTLV-I and implications for cell transformation","volume":"24","author":"Sun","year":"2005","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170521010645_CIT0010","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3390\/v3060886","article-title":"Targeting HTLV-1 activation of NF\u03baB in mouse models and ATLL patients","volume":"3","author":"Rauch","year":"2011","journal-title":"Viruses"},{"key":"key\n\t\t\t\t20170521010645_CIT0011","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1128\/JVI.75.5.2185-2193.2001","article-title":"Analysis of p53 inactivation in a human T-cell leukemia virus type 1 Tax transgenic mouse model","volume":"75","author":"Portis","year":"2001","journal-title":"J. Virol"},{"key":"key\n\t\t\t\t20170521010645_CIT0012","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nm1389","article-title":"Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I","volume":"12","author":"Hasegawa","year":"2006","journal-title":"Nat. Med"},{"key":"key\n\t\t\t\t20170521010645_CIT0013","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nm0507-527","article-title":"The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells","volume":"13","author":"Ohsugi","year":"2007","journal-title":"Nat. Med"},{"key":"key\n\t\t\t\t20170521010645_CIT0014","doi-asserted-by":"crossref","first-page":"e18518","DOI":"10.1371\/journal.pone.0018518","article-title":"Low CD4\/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice","volume":"6","author":"Ohsugi","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170521010645_CIT0015","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.leukres.2005.06.001","article-title":"In vitro and in vivo antitumor activity of the NF-\u03baB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line, HUT-102","volume":"30","author":"Ohsugi","year":"2006","journal-title":"Leuk. Res"},{"key":"key\n\t\t\t\t20170521010645_CIT0016","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/carcin\/bgi095","article-title":"In vivo antitumor activity of the NF-\u03baB inhibitor dehydroxymethylepoxyquinomicin in a mouse model of adult T-cell leukemia","volume":"26","author":"Ohsugi","year":"2005","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170521010645_CIT0017","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1677\/JOE-07-0217","article-title":"Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo","volume":"195","author":"Conradie","year":"2007","journal-title":"J. Endocrinol"},{"key":"key\n\t\t\t\t20170521010645_CIT0018","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00204-009-0498-8","article-title":"Elevation of cell proliferation via generation of reactive oxygen species by piperonyl butoxide contributes to its liver tumor-promoting effects in mice","volume":"84","author":"Kawai","year":"2010","journal-title":"Arch. Toxicol"},{"key":"key\n\t\t\t\t20170521010645_CIT0019","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.4049\/jimmunol.0902846","article-title":"c-Myb promotes the survival of CD4 + CD8 + double-positive thymocytes through upregulation of Bcl-xL","volume":"184","author":"Yuan","year":"2010","journal-title":"J. Immunol"},{"key":"key\n\t\t\t\t20170521010645_CIT0020","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/carcin\/20.4.715","article-title":"LOH and mutational analysis of p53 alleles in mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl) nitrosamine","volume":"20","author":"Morimura","year":"1999","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170521010645_CIT0021","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1182\/blood-2004-09-3646","article-title":"Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-\u03baB, as a strategy for chemoprevention and therapy of adult T-cell leukemia","volume":"106","author":"Watanabe","year":"2005","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170521010645_CIT0022","doi-asserted-by":"crossref","first-page":"16633","DOI":"10.1073\/pnas.0708043104","article-title":"Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations","volume":"104","author":"Feng","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170521010645_CIT0023","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0960-894X(00)00114-1","article-title":"Synthesis of NF-\u03baB activation inhibitors derived from epoxyquinomicin C","volume":"10","author":"Matsumoto","year":"2000","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"key\n\t\t\t\t20170521010645_CIT0024","doi-asserted-by":"crossref","first-page":"906","DOI":"10.7164\/antibiotics.50.906","article-title":"Epoxyquinomicins A, B, C and D, new antibiotics from Amycolatopsis. II. Effect on type II collagen-induced arthritis in mice","volume":"50","author":"Matsumoto","year":"1997","journal-title":"J. Antibiot. (Tokyo)"},{"key":"key\n\t\t\t\t20170521010645_CIT0025","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.canlet.2007.07.017","article-title":"Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with tax-deficient adult T-cell leukemia-derived cell lines","volume":"257","author":"Ohsugi","year":"2007","journal-title":"Cancer Lett"},{"key":"key\n\t\t\t\t20170521010645_CIT0026","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1182\/blood.V95.12.3939","article-title":"p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia\/lymphoma cells","volume":"95","author":"Takemoto","year":"2000","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170521010645_CIT0027","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170521010645_CIT0028","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/j.1349-7006.1991.tb01815.x","article-title":"Genetic alteration of p53 in some patients with adult T-cell leukemia","volume":"82","author":"Nagai","year":"1991","journal-title":"Jpn. J. Cancer Res"},{"key":"key\n\t\t\t\t20170521010645_CIT0029","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1349-7006.1993.tb02775.x","article-title":"Aberrant expression of the p53 tumor suppressor gene in adult T-cell leukemia and HTLV-I-infected cells","volume":"84","author":"Yamato","year":"1993","journal-title":"Jpn. J. Cancer Res"},{"key":"key\n\t\t\t\t20170521010645_CIT0030","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2008.12.002","article-title":"PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt","volume":"136","author":"Kawase","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170521010645_CIT0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1269\/jrr.43.1","article-title":"Pre-irradiation at a low dose-rate blunted p53 response","volume":"43","author":"Takahashi","year":"2002","journal-title":"J. Radiat. Res"},{"key":"key\n\t\t\t\t20170521010645_CIT0032","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1126\/science.287.5459.1824","article-title":"DNA damage-induced activation of p53 by the checkpoint kinase Chk2","volume":"287","author":"Hirao","year":"2000","journal-title":"Science"},{"key":"key\n\t\t\t\t20170521010645_CIT0033","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ccr.2010.10.034","article-title":"Loss of ATM\/Chk2\/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas","volume":"18","author":"Squatrito","year":"2010","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20170521010645_CIT0034","doi-asserted-by":"crossref","first-page":"7148","DOI":"10.1158\/0008-5472.CAN-10-1457","article-title":"Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4","volume":"70","author":"Xiong","year":"2010","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170521010645_CIT0035","first-page":"1991","article-title":"Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53","volume":"56","author":"Sala","year":"1996","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170521010645_CIT0036","doi-asserted-by":"crossref","first-page":"10326","DOI":"10.1074\/jbc.M412643200","article-title":"A novel NF-\u03baB pathway involving IKK\u03b2 and p65\/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity","volume":"280","author":"Jeong","year":"2005","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20170521010645_CIT0037","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1182\/blood-2003-12-4174","article-title":"HTLV-I Tax induces a novel interaction between p65\/RelA and p53 that results in inhibition of p53 transcriptional activity","volume":"104","author":"Jeong","year":"2004","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170521010645_CIT0038","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.1038\/sj.onc.1208825","article-title":"Activated AKT regulates NF-\u03baB activation, p53 inhibition and cell survival in HTLV-1-transformed cells","volume":"24","author":"Jeong","year":"2005","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170521010645_CIT0039","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1128\/MCB.20.10.3377-3386.2000","article-title":"Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-\u03baB pathway and is dependent on p53 phosphorylation","volume":"20","author":"Pise-Masison","year":"2000","journal-title":"Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20170521010645_CIT0040","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1128\/JVI.72.2.1165-1170.1998","article-title":"Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein","volume":"72","author":"Pise-Masison","year":"1998","journal-title":"J. Virol"},{"key":"key\n\t\t\t\t20170521010645_CIT0041","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.1128\/JVI.72.8.6348-6355.1998","article-title":"Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells","volume":"72","author":"Pise-Masison","year":"1998","journal-title":"J. Virol"},{"key":"key\n\t\t\t\t20170521010645_CIT0042","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/sj.onc.1203450","article-title":"HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration","volume":"19","author":"Ariumi","year":"2000","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170521010645_CIT0043","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/nrc2251","article-title":"CHK2 kinase: cancer susceptibility and cancer therapy\u2014two sides of the same coin?","volume":"7","author":"Antoni","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20170521010645_CIT0044","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1128\/JVI.02331-07","article-title":"Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response","volume":"82","author":"Chandhasin","year":"2008","journal-title":"J. Virol"},{"key":"key\n\t\t\t\t20170521010645_CIT0045","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/sj.onc.1209059","article-title":"Human T-cell leukemia virus type 1 Tax attenuates \u03b3-irradiation-induced apoptosis through physical interaction with Chk2","volume":"25","author":"Park","year":"2006","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170521010645_CIT0046","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1742-4690-9-114","article-title":"Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis","volume":"9","author":"Zane","year":"2012","journal-title":"Retrovirology"},{"key":"key\n\t\t\t\t20170521010645_CIT0047","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1349-7006.1989.tb02289.x","article-title":"Multi-step carcinogenesis model for adult T-cell leukemia","volume":"80","author":"Okamoto","year":"1989","journal-title":"Jpn. J. Cancer Res"},{"key":"key\n\t\t\t\t20170521010645_CIT0048","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/08830180801939272","article-title":"Current topics in prevention of human T-cell leukemia virus type i infection: NF-\u03baB inhibitors and APOBEC3","volume":"27","author":"Ohsugi","year":"2008","journal-title":"Int. Rev. Immunol"},{"key":"key\n\t\t\t\t20170521010645_CIT0049","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1349-7006.2006.00285.x","article-title":"Inhibition of tumor growth by NF-\u03baB inhibitors","volume":"97","author":"Umezawa","year":"2006","journal-title":"Cancer Sci"},{"key":"key\n\t\t\t\t20170521010645_CIT0050","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biopha.2011.02.003","article-title":"Possible role of peritoneal NF-\u03baB in peripheral inflammation and cancer: lessons from the inhibitor DHMEQ","volume":"65","author":"Umezawa","year":"2011","journal-title":"Biomed. Pharmacother"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/34\/9\/2129\/17293391\/bgt144.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T04:19:27Z","timestamp":1595737167000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article-lookup\/doi\/10.1093\/carcin\/bgt144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,30]]},"references-count":50,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,4,30]]},"published-print":{"date-parts":[[2013,9]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgt144","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4,30]]}}}