{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:19:12Z","timestamp":1779236352852,"version":"3.51.4"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CARCIN"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1093\/carcin\/bgu143","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T05:47:37Z","timestamp":1404280057000},"page":"2142-2153","source":"Crossref","is-referenced-by-count":27,"title":["Androgen deprivation induces phenotypic plasticity and promotes resistance to molecular targeted therapy in a<i>PTEN<\/i>-deficient mouse model of prostate cancer"],"prefix":"10.1093","volume":"35","author":[{"given":"Marco A.","family":"De Velasco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyoshi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Hatanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,7,1]]},"reference":[{"key":"2015103020132895000_35.9.2142.1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks888"},{"key":"2015103020132895000_35.9.2142.2","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-10-0204"},{"key":"2015103020132895000_35.9.2142.3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.2005"},{"key":"2015103020132895000_35.9.2142.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.05.006"},{"key":"2015103020132895000_35.9.2142.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.04.008"},{"key":"2015103020132895000_35.9.2142.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.04.047"},{"key":"2015103020132895000_35.9.2142.7","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1470"},{"key":"2015103020132895000_35.9.2142.8","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1300"},{"key":"2015103020132895000_35.9.2142.9","doi-asserted-by":"crossref","unstructured":"Amit I. (2007) Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy. Mol. Syst. Biol., 3, 151.","DOI":"10.1038\/msb4100195"},{"key":"2015103020132895000_35.9.2142.10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.13375"},{"key":"2015103020132895000_35.9.2142.11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603924"},{"key":"2015103020132895000_35.9.2142.12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604680"},{"key":"2015103020132895000_35.9.2142.13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.4751"},{"key":"2015103020132895000_35.9.2142.14","doi-asserted-by":"crossref","unstructured":"De Velasco M.A. (2012) Preclinical remodeling of human prostate cancer through the PTEN\/AKT pathway. Adv. Urol., 2012, 419348.","DOI":"10.1155\/2012\/419348"},{"key":"2015103020132895000_35.9.2142.15","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.5.1495-1503.2002"},{"key":"2015103020132895000_35.9.2142.16","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00134-0"},{"key":"2015103020132895000_35.9.2142.17","doi-asserted-by":"publisher","DOI":"10.1210\/me.11.9.1256"},{"key":"2015103020132895000_35.9.2142.18","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-07-2198"},{"key":"2015103020132895000_35.9.2142.19","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-0946"},{"key":"2015103020132895000_35.9.2142.20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4213"},{"key":"2015103020132895000_35.9.2142.21","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.12.6166"},{"key":"2015103020132895000_35.9.2142.22","unstructured":"Calderwooed S.A . (2013) Tumor heterogeneity, clonal evolution, and therapy resistance: an opportunity for multitargeting therapy. Discov. Med., 82, 188\u2013194."},{"key":"2015103020132895000_35.9.2142.23","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-12-0394"},{"key":"2015103020132895000_35.9.2142.24","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-0124"},{"key":"2015103020132895000_35.9.2142.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.03.040"},{"key":"2015103020132895000_35.9.2142.26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11456.x"},{"key":"2015103020132895000_35.9.2142.27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110846"},{"key":"2015103020132895000_35.9.2142.28","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0631"},{"key":"2015103020132895000_35.9.2142.29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800071200"},{"key":"2015103020132895000_35.9.2142.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2013.02.005"},{"key":"2015103020132895000_35.9.2142.31","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4519"},{"key":"2015103020132895000_35.9.2142.32","unstructured":"Montagutelli X . (2000) Effect of the genetic background on the phenotype of mouse mutations. J. Am. Soc. Nephrol., 16, S101\u2013S105."},{"key":"2015103020132895000_35.9.2142.33","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4143"},{"key":"2015103020132895000_35.9.2142.34","doi-asserted-by":"publisher","DOI":"10.1038\/nature03918"},{"key":"2015103020132895000_35.9.2142.35","doi-asserted-by":"publisher","DOI":"10.1038\/nature09677"},{"key":"2015103020132895000_35.9.2142.36","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3132"},{"key":"2015103020132895000_35.9.2142.37","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00215-0"},{"key":"2015103020132895000_35.9.2142.38","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-4385"},{"key":"2015103020132895000_35.9.2142.39","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0283"},{"key":"2015103020132895000_35.9.2142.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(03)00190-4"},{"key":"2015103020132895000_35.9.2142.41","doi-asserted-by":"publisher","DOI":"10.4161\/cc.4.10.2062"},{"key":"2015103020132895000_35.9.2142.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.12.017"},{"key":"2015103020132895000_35.9.2142.43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.171060098"},{"key":"2015103020132895000_35.9.2142.44","doi-asserted-by":"publisher","DOI":"10.1038\/nm1052"},{"key":"2015103020132895000_35.9.2142.45","doi-asserted-by":"crossref","unstructured":"Kinkade C.W. (2008) Targeting AKT\/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J. Clin. Invest., 118, 3051\u20133064.","DOI":"10.1172\/JCI34764"},{"key":"2015103020132895000_35.9.2142.46","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0085"},{"key":"2015103020132895000_35.9.2142.47","unstructured":"Gao J. (2001) Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells. Cancer Res., 61, 5038\u20135044."},{"key":"2015103020132895000_35.9.2142.48","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0090061"},{"key":"2015103020132895000_35.9.2142.49","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3498"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/35\/9\/2142\/14133965\/bgu143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T18:42:58Z","timestamp":1503427378000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article-lookup\/doi\/10.1093\/carcin\/bgu143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,1]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,8,27]]},"published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1093\/carcin\/bgu143"],"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgu143","relation":{},"ISSN":["0143-3334","1460-2180"],"issn-type":[{"value":"0143-3334","type":"print"},{"value":"1460-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,1]]}}}