{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:09:37Z","timestamp":1785456577378,"version":"3.56.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 CA129347"],"award-info":[{"award-number":["RO1 CA129347"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA047904"],"award-info":[{"award-number":["P30 CA047904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,9]]},"DOI":"10.1093\/carcin\/bgx114","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T19:09:44Z","timestamp":1507316984000},"page":"134-145","source":"Crossref","is-referenced-by-count":23,"title":["Prevention of breast cancer-induced osteolytic bone resorption by benzyl isothiocyanate"],"prefix":"10.1093","volume":"39","author":[{"given":"Subrata K","family":"Pore","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Ryeong","family":"Hahm","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D","family":"Latoche","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"In Vivo Imaging Facility, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"In Vivo Imaging Facility, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Shuai","sequence":"additional","affiliation":[{"name":"Biostatistics Facility, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivendra V","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"key\n\t\t\t\t20180328170006_CIT0001","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/oxfordjournals.epirev.a036115","article-title":"Reproductive factors and breast cancer","volume":"15","author":"Kelsey","year":"1993","journal-title":"Epidemiol. Rev"},{"key":"key\n\t\t\t\t20180328170006_CIT0002","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0140-6736(95)92713-1","article-title":"Breast cancer: cause and prevention","volume":"346","author":"Hulka","year":"1995","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180328170006_CIT0003","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/1055-9965.EPI-10-0329","article-title":"Genome-based prediction of breast cancer risk in the general population: a modeling study based on meta-analyses of genetic associations","volume":"20","author":"van Zitteren","year":"2011","journal-title":"Cancer Epidemiol. Biomarkers Prev"},{"key":"key\n\t\t\t\t20180328170006_CIT0004","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours","volume":"406","author":"Perou","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328170006_CIT0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA. Cancer J. Clin"},{"key":"key\n\t\t\t\t20180328170006_CIT0006","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrc1670","article-title":"Breast cancer metastasis: markers and models","volume":"5","author":"Weigelt","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20180328170006_CIT0007","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1097\/00000421-200212001-00006","article-title":"Future directions in the treatment and prevention of bone metastases","volume":"25","author":"Coleman","year":"2002","journal-title":"Am. J. Clin. Oncol"},{"key":"key\n\t\t\t\t20180328170006_CIT0008","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrc867","article-title":"Metastasis to bone: causes, consequences and therapeutic opportunities","volume":"2","author":"Mundy","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20180328170006_CIT0009","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrc3055","article-title":"Cancer to bone: a fatal attraction","volume":"11","author":"Weilbaecher","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20180328170006_CIT0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jbo.2016.02.008","article-title":"The role of osteoclasts in breast cancer bone metastasis","volume":"5","author":"Le Pape","year":"2016","journal-title":"J. Bone Oncol"},{"key":"key\n\t\t\t\t20180328170006_CIT0011","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1200\/JCO.2009.25.9820","article-title":"Metastatic behavior of breast cancer subtypes","volume":"28","author":"Kennecke","year":"2010","journal-title":"J. Clin. Oncol"},{"key":"key\n\t\t\t\t20180328170006_CIT0012","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0025-6196(11)60752-0","article-title":"Adverse effects of bisphosphonates: implications for osteoporosis management","volume":"84","author":"Kennel","year":"2009","journal-title":"Mayo Clin. Proc"},{"key":"key\n\t\t\t\t20180328170006_CIT0013","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s11096-017-0455-1","article-title":"Use and safety of denosumab in cancer patients","volume":"39","author":"Manzaneque","year":"2017","journal-title":"Int. J. Clin. Pharm"},{"key":"key\n\t\t\t\t20180328170006_CIT0014","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrc3017","article-title":"Molecular targets of phytochemicals for cancer prevention","volume":"11","author":"Lee","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20180328170006_CIT0015","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.2174\/138945012804545533","article-title":"Mitosis-targeting natural products for cancer prevention and therapy","volume":"13","author":"Rao","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"key\n\t\t\t\t20180328170006_CIT0016","first-page":"247","article-title":"Neem components as potential agents for cancer prevention and treatment","volume":"1846","author":"Hao","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20180328170006_CIT0017","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/j.1745-7254.2007.00683.x","article-title":"Oriental herbs as a source of novel anti-androgen and prostate cancer chemopreventive agents","volume":"28","author":"Lu","year":"2007","journal-title":"Acta Pharmacol. Sin"},{"key":"key\n\t\t\t\t20180328170006_CIT0018","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/jn\/134.5.1134","article-title":"Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype","volume":"134","author":"Ambrosone","year":"2004","journal-title":"J. Nutr"},{"key":"key\n\t\t\t\t20180328170006_CIT0019","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.breast.2012.07.013","article-title":"Cruciferous vegetables intake is inversely associated with risk of breast cancer: a meta-analysis","volume":"22","author":"Liu","year":"2013","journal-title":"Breast"},{"key":"key\n\t\t\t\t20180328170006_CIT0020","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1093\/carcin\/bgs216","article-title":"Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research","volume":"33","author":"Singh","year":"2012","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20180328170006_CIT0021","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/nutrit\/nuw010","article-title":"Chemopreventive properties of 3,3\u2019-diindolylmethane in breast cancer: evidence from experimental and human studies","volume":"74","author":"Thomson","year":"2016","journal-title":"Nutr. Rev"},{"key":"key\n\t\t\t\t20180328170006_CIT0022","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/jnci\/58.2.395","article-title":"Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds","volume":"58","author":"Wattenberg","year":"1977","journal-title":"J. Natl. Cancer Inst"},{"key":"key\n\t\t\t\t20180328170006_CIT0023","doi-asserted-by":"crossref","first-page":"9473","DOI":"10.1158\/0008-5472.CAN-09-2960","article-title":"Prevention of mammary carcinogenesis in MMTV-neu mice by cruciferous vegetable constituent benzyl isothiocyanate","volume":"69","author":"Warin","year":"2009","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20180328170006_CIT0024","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/bcr2416","article-title":"Epithelial to mesenchymal transition and breast cancer","volume":"11","author":"Tomaskovic-Crook","year":"2009","journal-title":"Breast Cancer Res"},{"key":"key\n\t\t\t\t20180328170006_CIT0025","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10911-010-9173-1","article-title":"Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer","volume":"15","author":"Creighton","year":"2010","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"key\n\t\t\t\t20180328170006_CIT0026","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1158\/1940-6207.CAPR-10-0306","article-title":"Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells","volume":"4","author":"Sehrawat","year":"2011","journal-title":"Cancer Prev. Res. (Phila)"},{"key":"key\n\t\t\t\t20180328170006_CIT0027","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1093\/carcin\/bgg023","article-title":"Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2\/M arrest and inducing apoptosis","volume":"24","author":"Xiao","year":"2003","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20180328170006_CIT0028","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/jnci\/djt153","article-title":"Metabolic alterations in mammary cancer prevention by withaferin A in a clinically relevant mouse model","volume":"105","author":"Hahm","year":"2013","journal-title":"J. Natl. Cancer Inst"},{"key":"key\n\t\t\t\t20180328170006_CIT0029","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/jnci\/djr029","article-title":"Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer","volume":"103","author":"Powolny","year":"2011","journal-title":"J. Natl. Cancer Inst"},{"key":"key\n\t\t\t\t20180328170006_CIT0030","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key\n\t\t\t\t20180328170006_CIT0031","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/jnci\/djs485","article-title":"Inhibition of breast cancer metastases by a novel inhibitor of TGF\u03b2 receptor 1","volume":"105","author":"Fang","year":"2013","journal-title":"J. Natl. Cancer Inst"},{"key":"key\n\t\t\t\t20180328170006_CIT0032","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1158\/1078-0432.CCR-10-1891","article-title":"Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K\/AKT\/FOXO pathway","volume":"17","author":"Boreddy","year":"2011","journal-title":"Clin. Cancer Res"},{"key":"key\n\t\t\t\t20180328170006_CIT0033","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/117822341000400004","article-title":"The expression patterns of ER, PR, HER2, CK5\/6, EGFR, Ki-67 and AR by immunohistochemical analysis in breast cancer cell lines","volume":"4","author":"Subik","year":"2010","journal-title":"Breast Cancer (Auckl)"},{"key":"key\n\t\t\t\t20180328170006_CIT0034","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1158\/1078-0432.CCR-10-2507","article-title":"Molecular pathways: osteoclast-dependent and osteoclast-independent roles of the RANKL\/RANK\/OPG pathway in tumorigenesis and metastasis","volume":"18","author":"Dougall","year":"2012","journal-title":"Clin. Cancer Res"},{"key":"key\n\t\t\t\t20180328170006_CIT0035","doi-asserted-by":"crossref","first-page":"178","DOI":"10.5312\/wjo.v4.i4.178","article-title":"Role of RANKL\/RANK in primary and secondary breast cancer","volume":"4","author":"Yoneda","year":"2013","journal-title":"World J. Orthop"},{"key":"key\n\t\t\t\t20180328170006_CIT0036","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1111\/febs.13645","article-title":"RANK as a therapeutic target in cancer","volume":"283","author":"Gonz\u00e1lez-Su\u00e1rez","year":"2016","journal-title":"FEBS J"},{"key":"key\n\t\t\t\t20180328170006_CIT0037","doi-asserted-by":"crossref","first-page":"23971","DOI":"10.1074\/jbc.M302457200","article-title":"Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-\/- mice by RANKL transgene","volume":"278","author":"Enomoto","year":"2003","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180328170006_CIT0038","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10555-006-9032-0","article-title":"Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone","volume":"25","author":"Pratap","year":"2006","journal-title":"Cancer Metastasis Rev"},{"key":"key\n\t\t\t\t20180328170006_CIT0039","doi-asserted-by":"crossref","first-page":"20969","DOI":"10.3390\/ijms160920969","article-title":"Role of RUNX2 in breast carcinogenesis","volume":"16","author":"Wysokinski","year":"2015","journal-title":"Int. J. Mol. Sci"},{"key":"key\n\t\t\t\t20180328170006_CIT0040","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra030831","article-title":"Mechanisms of bone metastasis","volume":"350","author":"Roodman","year":"2004","journal-title":"N. Engl. J. Med"},{"issue":"20 Pt 2","key":"key\n\t\t\t\t20180328170006_CIT0041","doi-asserted-by":"crossref","first-page":"6213s","DOI":"10.1158\/1078-0432.CCR-06-1007","article-title":"Basic mechanisms responsible for osteolytic and osteoblastic bone metastases","volume":"12","author":"Guise","year":"2006","journal-title":"Clin. Cancer Res"},{"key":"key\n\t\t\t\t20180328170006_CIT0042","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/SPC.0b013e32830baea9","article-title":"Cathepsin K inhibitors as treatment of bone metastasis","volume":"2","author":"Le Gall","year":"2008","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"key\n\t\t\t\t20180328170006_CIT0043","doi-asserted-by":"crossref","first-page":"9894","DOI":"10.1158\/0008-5472.CAN-06-3940","article-title":"A cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden","volume":"67","author":"Le Gall","year":"2007","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20180328170006_CIT0044","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.canlet.2007.07.007","article-title":"Bisphosphonates in cancer therapy","volume":"257","author":"Stresing","year":"2007","journal-title":"Cancer Lett"},{"key":"key\n\t\t\t\t20180328170006_CIT0045","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0140-6736(15)60995-3","article-title":"Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"386","author":"Gnant","year":"2015","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180328170006_CIT0046","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4137\/CGM.S11284","article-title":"Animal cancer models of skeletal metastasis","volume":"6","author":"Hibberd","year":"2013","journal-title":"Cancer Growth Metastasis"},{"key":"key\n\t\t\t\t20180328170006_CIT0047","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1177\/0300985815586223","article-title":"Animal Models of Bone Metastasis","volume":"52","author":"Simmons","year":"2015","journal-title":"Vet. Pathol"},{"key":"key\n\t\t\t\t20180328170006_CIT0048","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1038\/sj.bjc.6603740","article-title":"Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer","volume":"96","author":"Duivenvoorden","year":"2007","journal-title":"Br. J. Cancer"},{"key":"key\n\t\t\t\t20180328170006_CIT0049","doi-asserted-by":"crossref","first-page":"e90099","DOI":"10.1371\/journal.pone.0090099","article-title":"Gasdermin-B promotes invasion and metastasis in breast cancer cells","volume":"9","author":"Hergueta-Redondo","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328170006_CIT0050","doi-asserted-by":"crossref","first-page":"21346","DOI":"10.1074\/jbc.M112.355834","article-title":"Identification of NOG as a specific breast cancer bone metastasis-supporting gene","volume":"287","author":"Tarragona","year":"2012","journal-title":"J. Biol. Chem"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/39\/2\/134\/24347105\/bgx114.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T01:29:14Z","timestamp":1750901354000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article\/39\/2\/134\/4443131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,11]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,10,11]]},"published-print":{"date-parts":[[2018,2,9]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgx114","relation":{},"ISSN":["0143-3334","1460-2180"],"issn-type":[{"value":"0143-3334","type":"print"},{"value":"1460-2180","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,2]]},"published":{"date-parts":[[2017,10,11]]}}}