{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:49:15Z","timestamp":1777531755569,"version":"3.51.4"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["F31CA192664"],"award-info":[{"award-number":["F31CA192664"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R24-AI-059830"],"award-info":[{"award-number":["R24-AI-059830"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IOS-1456213"],"award-info":[{"award-number":["IOS-1456213"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The conditions that lead to antitumor or protumor functions of natural killer T (NKT) cells against mammalian tumors are only partially understood. Therefore, insights into the evolutionary conservation of NKT and their analogs\u2014innate-like T (iT) cells\u2014may reveal factors that contribute to tumor eradication. As such, we investigated the amphibian Xenopus laevis iT cells and interacting MHC class I-like (XNC or mhc1b.L) genes against ff-2 thymic lymphoid tumors. Upon ff-2 intraperitoneal transplantation into syngeneic tadpoles, two iT cell subsets iV\u03b16 and iV\u03b122, characterized by an invariant T-cell receptor \u03b1 chain rearrangement (V\u03b16-J\u03b11.43 and V\u03b122-J\u03b11.32 respectively), were recruited to the peritoneum, concomitant with a decreased level of these transcripts in the spleen and thymus. To address the hypothesize that different iT cell subsets have distinct, possibly opposing, roles upon ff-2 tumor challenge, we determined whether ff-2 tumor growth could be manipulated by impairing V\u03b16 iT cells or by deleting their restricting element, the XNC gene, XNC10 (mhc1b10.1.L), on ff-2 tumors. Accordingly, the in vivo depletion of V\u03b16 iT cells using XNC10-tetramers enhanced tumor growth, indicating V\u03b16 iT cell-mediated antitumor activities. However, XNC10-deficient transgenic tadpoles that also lack V\u03b16 iT cells were resistant to ff-2 tumors, uncovering a potential new function of XNC10 besides V\u03b16 iT cell development. Furthermore, the CRISPR\/Cas9-mediated knockout of XNC10 in ff-2 tumors broke the immune tolerance. Together, our findings demonstrate the relevance of XNC10\/iT cell axis in controlling Xenopus tumor tolerance or rejection.<\/jats:p>","DOI":"10.1093\/carcin\/bgz100","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T11:09:26Z","timestamp":1559300966000},"page":"924-935","source":"Crossref","is-referenced-by-count":5,"title":["Impacts of the MHC class I-like XNC10 and innate-like T cells on tumor tolerance and rejection in the amphibian Xenopus"],"prefix":"10.1093","volume":"40","author":[{"given":"Maureen","family":"Banach","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva-Stina","family":"Edholm","sequence":"first","affiliation":[{"name":"The Norwegian College of Fishery Science, UiT The Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdellatif","family":"Benraiss","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4380-1476","authenticated-orcid":false,"given":"Jacques","family":"Robert","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,1]]},"reference":[{"key":"2020053120095811300_CIT0001","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/ni.3298","article-title":"The burgeoning family of unconventional T cells","volume":"16","author":"Godfrey","year":"2015","journal-title":"Nat. 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