{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:35:47Z","timestamp":1772138147984,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Centre for Cell Science"},{"name":"Department of Biotechnology, Government of India","award":["BT\/IN\/FINNISH\/25\/SB\/2009"],"award-info":[{"award-number":["BT\/IN\/FINNISH\/25\/SB\/2009"]}]},{"name":"Department of Biotechnology, Government of India","award":["BT\/Indo-Aus\/06\/03\/2011"],"award-info":[{"award-number":["BT\/Indo-Aus\/06\/03\/2011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cellular plasticity and transitional phenotypes add to complexities of cancer metastasis that can be initiated by single cell epithelial to mesenchymal transition (EMT) or cooperative cell migration (CCM). Our study identifies novel regulatory cross-talks between Tcf21 and Slug in mediating phenotypic and migration plasticity in high-grade serous ovarian adenocarcinoma (HGSC). Differential expression and subcellular localization associate Tcf21, Slug with epithelial, mesenchymal phenotypes, respectively; however, gene manipulation approaches identify their association with additional intermediate phenotypic states, implying the existence of a multistep epithelial-mesenchymal transition program. Live imaging further associated distinct migratory modalities with the Tcf21\/Slug status of cell systems and discerned proliferative\/passive CCM, active CCM and EMT modes of migration. Tcf21\u2013Slug balance identified across a phenotypic spectrum in HGSC cell lines, associated with microenvironment-induced transitions and the emergence of an epithelial phenotype following drug exposure. Phenotypic transitions and associated functionalities following drug exposure were affirmed to ensue from occupancy of Slug promoter E-box sequences by Tcf21. Our study effectively provides a framework for understanding the relevance of ovarian cancer plasticity as a function of two transcription factors.<\/jats:p>","DOI":"10.1093\/carcin\/bgz119","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T10:17:37Z","timestamp":1561457857000},"page":"515-526","source":"Crossref","is-referenced-by-count":20,"title":["Functional balance between Tcf21\u2013Slug defines cellular plasticity and migratory modalities in high grade serous ovarian cancer cell lines"],"prefix":"10.1093","volume":"41","author":[{"given":"Sagar S","family":"Varankar","sequence":"first","affiliation":[{"name":"National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhuri","family":"More","sequence":"first","affiliation":[{"name":"National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ancy","family":"Abraham","sequence":"first","affiliation":[{"name":"National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kshama","family":"Pansare","sequence":"first","affiliation":[{"name":"Institute for Plasma Research & Tata Memorial Centre, Kharghar, Navi-Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brijesh","family":"Kumar","sequence":"first","affiliation":[{"name":"National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivedhitha J","family":"Narayanan","sequence":"first","affiliation":[{"name":"National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohit Kumar","family":"Jolly","sequence":"first","affiliation":[{"name":"Center for Theoretical Biological Physics, Rice University, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash M","family":"Mali","sequence":"first","affiliation":[{"name":"National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4380-1476","authenticated-orcid":false,"given":"Sharmila A","family":"Bapat","sequence":"first","affiliation":[{"name":"National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"2020061704232402800_CIT0001","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1242\/dev.005439","article-title":"Mammary development in the embryo and adult: a journey of morphogenesis and commitment","volume":"135","author":"Watson","year":"2008","journal-title":"Development"},{"key":"2020061704232402800_CIT0002","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.stem.2012.05.023","article-title":"Developmental stage and time dictate the fate of Wnt\/\u03b2-catenin-responsive stem cells in the mammary gland","volume":"11","author":"van Amerongen","year":"2012","journal-title":"Cell Stem Cell"},{"key":"2020061704232402800_CIT0003","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.devcel.2017.10.001","article-title":"Skin and its regenerative powers: an alliance between stem cells and their niche","volume":"43","author":"Gonzales","year":"2017","journal-title":"Dev. 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