{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:03:52Z","timestamp":1792785832057,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T00:00:00Z","timestamp":1577145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Key R&D Program of China","award":["2018YFC2000700"],"award-info":[{"award-number":["2018YFC2000700"]}]},{"name":"National Key R&D Program of China","award":["2017YFC0907001"],"award-info":[{"award-number":["2017YFC0907001"]}]},{"name":"National Nature Science Foundation","award":["81302507"],"award-info":[{"award-number":["81302507"]}]},{"name":"National Nature Science Foundation","award":["81630086"],"award-info":[{"award-number":["81630086"]}]},{"name":"National Nature Science Foundation","award":["81427805"],"award-info":[{"award-number":["81427805"]}]},{"name":"Key Research Program","award":["ZDRW-ZS-2017-1"],"award-info":[{"award-number":["ZDRW-ZS-2017-1"]}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16391903700"],"award-info":[{"award-number":["16391903700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16411966800"],"award-info":[{"award-number":["16411966800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["2018YFC1705103"],"award-info":[{"award-number":["2018YFC1705103"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Helicobacter pylori infection induces gastric cancer (GC) development through a progressive cascade; however, the roles of the microRNAs that are involved in the cascade and the underlying mechanisms are still unclear. Here, we found that microRNA-204 was suppressed in gastric mucosal cells in response to H.pylori infection and downregulated in GC tissues due to aberrant methylation of the promoter of its host gene, TRPM3. Helicobacter pylori induced a progressive downregulation of microRNA-204 from superficial gastritis to intestinal metaplasia, with an accompanying increment of the methylated levels of CpG sites in the TRPM3 promoter. With the GC cellular models of AGS, MGC-803 or BGC-823, we found that microRNA-204 suppressed the tumor necrosis factor (TNF)-\u03b1-induced activation of NF-\u03baB signaling pathways and, in animal models, inhibited tumor growth and metastasis. The conditional supernatant of microRNA-204 overexpression GC cells led to reduced tube formation of human umbilical vein endothelial cells. A target gene for microRNA-204 was BIRC2, and in GC cells, BIRC2 knockdown recapitulated the biological phenotype of microRNA-204 overexpression. BIRC2 overexpression promoted the metastasis of GC cells and rescued the inhibition activities of microRNA-204 on cell migration and the NF-\u03baB signaling pathway. Moreover, lower microRNA-204 and higher BIRC2 expression levels were associated with a poorer prognosis of GC patients. These results demonstrate that epigenetic silencing of microRNA-204 induced by H.pylori infection augments the NF-\u03baB signaling pathway in H.pylori-induced gastritis and GC, potentially providing novel intervention targets for these diseases.<\/jats:p>\n                  <jats:p>MicroRNA-204 was epigenetically down-regulated by H. pylori infection in gastric mucosal cells. It led to enhanced BIRC2 expression level and BIRC2\/TNF-a\/NF-kB signaling pathway activities, which promoted angiogenesis and metastasis of gastric cancer cells.<\/jats:p>","DOI":"10.1093\/carcin\/bgz143","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T15:26:29Z","timestamp":1567610789000},"page":"430-441","source":"Crossref","is-referenced-by-count":35,"title":["Epigenetic silencing of microRNA-204 by Helicobacter pylori augments the NF-\u03baB signaling pathway in gastric cancer development and progression"],"prefix":"10.1093","volume":"41","author":[{"given":"Peizhan","family":"Chen","sequence":"first","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Guo","sequence":"first","affiliation":[{"name":"Key Laboratory of Food Safety Research, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuming","family":"Wu","sequence":"first","affiliation":[{"name":"Nantong Center for Disease Control and Prevention, Nantong, P.R. China"},{"name":"Nantong Tumor Hospital, Nantong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingquan","family":"Li","sequence":"first","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Duan","sequence":"first","affiliation":[{"name":"Key Laboratory of Food Safety Research, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ba","sequence":"first","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. 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