{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:32:35Z","timestamp":1792794755470,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T00:00:00Z","timestamp":1567209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Fund for Scientific Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Glioblastoma (GBM) is the most frequent and aggressive primary tumor in the central nervous system. Previously, the secretion of CXCL12 in the brain subventricular zones has been shown to attract GBM cells and protect against irradiation. However, the exact molecular mechanism behind this radioprotection is still unknown. Here, we demonstrate that CXCL12 modulates the phosphorylation of MAP kinases and their regulator, the nuclear MAP kinase phosphatase 1 (MKP1). We further show that MKP1 is able to decrease GBM cell death and promote DNA repair after irradiation by regulating major apoptotic players, such as Jun-N-terminal kinase, and by stabilizing the DNA repair protein RAD51. Increases in MKP1 levels caused by different corticoid treatments should be reexamined for GBM patients, particularly during their radiotherapy sessions, in order to prevent or to delay the relapses of this tumor.<\/jats:p>","DOI":"10.1093\/carcin\/bgz151","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T11:47:11Z","timestamp":1567165631000},"page":"417-429","source":"Crossref","is-referenced-by-count":11,"title":["MKP1 phosphatase is recruited by CXCL12 in glioblastoma cells and plays a role in DNA strand breaks repair"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6252-3080","authenticated-orcid":false,"given":"Matthias","family":"Dedobbeleer","sequence":"first","affiliation":[{"name":"Laboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Willems","sequence":"first","affiliation":[{"name":"Laboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Lambert","sequence":"first","affiliation":[{"name":"Laboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Lombard","sequence":"first","affiliation":[{"name":"Laboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Li\u00e8ge, Li\u00e8ge, Belgium"},{"name":"Department of Neurosurgery, CHU of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Digregorio","sequence":"first","affiliation":[{"name":"Laboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Noel","family":"Lumapat","sequence":"first","affiliation":[{"name":"Laboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Di Valentin","sequence":"first","affiliation":[{"name":"Viral Vector Platform, GIGA Institute, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Freeman","sequence":"first","affiliation":[{"name":"Laboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Goffart","sequence":"first","affiliation":[{"name":"The T&P Bohnenn Laboratory for Neuro-Oncology, Department of Neurosurgery, UMC Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Scholtes","sequence":"first","affiliation":[{"name":"Laboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Li\u00e8ge, Li\u00e8ge, Belgium"},{"name":"Department of Neurosurgery, CHU of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Rogister","sequence":"first","affiliation":[{"name":"Laboratory of Nervous System Diseases and Therapy, GIGA-Neuroscience, University of Li\u00e8ge, Li\u00e8ge, Belgium"},{"name":"Department of Neurology, CHU of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,31]]},"reference":[{"key":"2020061704232812000_CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/brainsci7120166","article-title":"Advances in brain tumor surgery for glioblastoma in adults","volume":"7","author":"Lara-Velazquez","year":"2017","journal-title":"Brain Sci."},{"key":"2020061704232812000_CIT0002","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jnci.2016.07.001","article-title":"Management of glioblastoma after recurrence: a changing paradigm","volume":"28","author":"Mallick","year":"2016","journal-title":"J. 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