{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:06Z","timestamp":1740126426250,"version":"3.37.3"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,20]]},"abstract":"<jats:p>A 78-year-old man received immunotherapy for in-transit metastatic melanoma papulonodules on his left lower abdomen in the form of intralesional injections of talimogene laherparepvec (T-VEC), an oncolytic genetically modified herpes virus. Despite therapy, the colour and size of the lesions remained clinically unchanged; however, histopathological examination revealed only melanophages in the absence of melanoma cells. The diagnosis of tumoral melanosis secondary to immunotherapy with T-VEC was made. This case emphasizes the importance of histopathological evaluation in assessing response to immunotherapy of in-transit metastatic melanoma lesions.<\/jats:p>","DOI":"10.1093\/ced\/llac002","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T14:22:44Z","timestamp":1674224564000},"page":"57-59","source":"Crossref","is-referenced-by-count":0,"title":["Papulonodular pigmented lesions in a patient with Stage IV malignant melanoma"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9090-6380","authenticated-orcid":false,"given":"Maged","family":"Daruish","sequence":"first","affiliation":[{"name":"Department of Dermatopathology, St John\u2019s institute of Dermatology , Guy\u2019s and St Thomas\u2019 NHS Trust, London, 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