{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:59:31Z","timestamp":1758815971952,"version":"3.37.3"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Metformin is an established staple drug in the management of Type 2 diabetes mellitus. In this systematic review, we sought to establish the clinical utility of metformin in a range of dermatological conditions. The pathophysiology of acne vulgaris and polycystic ovarian syndrome (PCOS) is well suited to the pharmacological profile of metformin, and we found evidence for its efficacy in managing these conditions. We found some evidence for the use of metformin particularly in acne and PCOS; however, the evidence base is of mixed quality. There is scope for clinicians to consider metformin as an adjunct therapy in acne and PCOS. There is generally insufficient evidence to recommend metformin in other dermatological conditions.<\/jats:p>","DOI":"10.1093\/ced\/llac027","type":"journal-article","created":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T17:57:32Z","timestamp":1673805452000},"page":"73-79","source":"Crossref","is-referenced-by-count":4,"title":["A systematic review of the uses of metformin in dermatology"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0182-9526","authenticated-orcid":false,"given":"Sami","family":"Raza","sequence":"first","affiliation":[{"name":"Department of Medicine, Walsall Healthcare NHS Trust , UK"},{"name":"Faculty of Medicine, Health and Life Science, Swansea University , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firas","family":"Al-Niaimi","sequence":"additional","affiliation":[{"name":"University of Aalborg , Aalborg , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-791X","authenticated-orcid":false,"given":"Faisal R","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mid-Cheshire NHS Foundation Trust , UK"},{"name":"St John\u2019s Institute of Dermatology , Guy's and St Thomas' NHS Foundation Trust, London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"author":"National Institute for Health and Care Excellence","key":"2023100307121557400_llac027-B1"},{"key":"2023100307121557400_llac027-B2","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/jdv.12116","article-title":"Metformin in dermatology: an overview","volume":"27","author":"Badr","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023100307121557400_llac027-B3","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/ced.14239","article-title":"Acne treatments: future trajectories","volume":"45","author":"Dessinioti","year":"2020","journal-title":"Clin Exp Dermatol"},{"key":"2023100307121557400_llac027-B4","doi-asserted-by":"crossref","first-page":"859.e1","DOI":"10.1016\/j.jaad.2014.05.009","article-title":"Polycystic ovary syndrome: a review for dermatologists. 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