{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T15:25:46Z","timestamp":1774020346004,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory condition of the pilosebaceous unit characterized by inflammation and hyperkeratinization. A small but significant proportion of patients with HS have a strong genetic susceptibility to (or a syndromic form of) the disease. Current HS treatment guidelines prioritize patients who manifest classic HS and may therefore not be suitable for the minority of patients harbouring genetically driven forms of disease. In this manuscript, we review the extant literature with regards to therapeutic strategies used for patients with HS having disease-associated genetic variants and syndromic forms of the condition. The findings of this review suggest that patients with HS harbouring underlying genetic variants may not be adequately represented in current European and British HS treatment guidelines. Moreover, these patients may be less responsive to the recommended therapeutic options. We therefore make recommendations for future therapeutic guidelines to incorporate considerations for the management of this patient subset.<\/jats:p>","DOI":"10.1093\/ced\/llac045","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T21:40:42Z","timestamp":1673473242000},"page":"67-72","source":"Crossref","is-referenced-by-count":4,"title":["Management of patients with hidradenitis suppurativa having underlying genetic variation: a systematic review and a call for precision medicine"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3705-0119","authenticated-orcid":false,"given":"Dillon","family":"Mintoff","sequence":"first","affiliation":[{"name":"Department of Dermatology, Mater Dei Hospital , Malta"},{"name":"Department of Pathology, Faculty of Medicine and Surgery, University of Malta , Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7332-874X","authenticated-orcid":false,"given":"Nikolai P","family":"Pace","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine and Surgery, University of Malta , Malta"},{"name":"Centre for Molecular Medicine and Biobanking, University of Malta , Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0639-3055","authenticated-orcid":false,"given":"Isabella","family":"Borg","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine and Surgery, University of Malta , Malta"},{"name":"Centre for Molecular Medicine and Biobanking, University of Malta , Malta"},{"name":"Department of Pathology, Mater Dei Hospital , Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"2023100307114111500_llac045-B1","doi-asserted-by":"crossref","first-page":"861241","DOI":"10.3389\/fgene.2022.861241","article-title":"The genomic architecture of hidradenitis suppurativa\u2014a systematic review","volume":"13","author":"Pace","year":"2022","journal-title":"Front Genet"},{"key":"2023100307114111500_llac045-B2","doi-asserted-by":"crossref","first-page":"962449","DOI":"10.3389\/fgene.2022.962449","article-title":"Interpreting the spectrum of gamma-secretase complex missense variation in the context of hidradenitis suppurativa \u2013 an in-silico study","volume":"13","author":"Mintoff","year":"2022","journal-title":"Front Genet"},{"key":"2023100307114111500_llac045-B3","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/jdv.12966","article-title":"European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa","volume":"29","author":"Zouboulis","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023100307114111500_llac045-B4","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/bjd.17466","article-title":"Association of pyrin mutations and autoinflammation with complex phenotype hidradenitis suppurativa: a case-control study","volume":"180","author":"Vural","year":"2019","journal-title":"Br J Dermatol"},{"key":"2023100307114111500_llac045-B5","doi-asserted-by":"crossref","first-page":"883811","DOI":"10.3389\/fimmu.2022.883811","article-title":"Case report: comorbid hyper-IgD syndrome and hidradenitis suppurativa \u2013 a new syndromic form of HS? 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