{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:40:39Z","timestamp":1790635239264,"version":"4.1.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>High-risk mucosal human papillomavirus (HR-HPV) seems to play a role in cutaneous squamous cell carcinoma (cSCC), particularly in nail tumours, where genitodigital transmission has been suggested. The role of HR-HPV in nonungual cSCC of the finger needs to be clarified.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To evaluate the prevalence, clinicopathological characteristics, surrogates and outcomes of HR-HPV in cSCC of the finger.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was an observational bicentric study including patients with an excised in situ or invasive cSCC located on the finger. Differences in HR-HPV and non-HR-HPV tumours were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty-five patients (45 tumours) were included. HR-HPV was detected in 33% of cases (22% HPV type 16). The mean age was lower in patients with HR-HPV than in those with non-HR-HPV (62\u00b74 vs. 81\u00b71\u2005years, P = 0\u00b7001). HR-HPV tumours were smaller (10\u2005mm vs. 15\u2005mm, P = 0\u00b707) and more frequently intraepidermal (60% vs. 20%, P = 0\u00b7004). The absence of elastosis (P = 0\u00b7030) and inflammation (P = 0\u00b7026) and the presence of basaloid morphology (P = 0\u00b7003) were surrogates of HR-HPV detection. Mean p16 positivity was 61% in HR-HPV and 36% in non-HR-HPV tumours (P = 0\u00b7061). Recurrence after surgery was more common in HR-HPV tumours (58% vs. 34%), although this was not statistically significant. HR-HPV was detected in 27% of the nonungual tumours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>HR-HPV-associated cSCC of the finger appears in younger patients, is smaller and is less infiltrative than non-HR-HPV tumours. The presence of a basaloid morphology and the absence of elastosis and inflammation could be used as markers for HR-HPV detection. The high prevalence of HR-HPV in nonungual cSCC suggests its aetiopathogenic role in these tumours.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llac086","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T14:24:13Z","timestamp":1674224653000},"page":"211-217","source":"Crossref","is-referenced-by-count":6,"title":["High-risk mucosal human papillomavirus-associated squamous cell carcinoma of the fingers presents distinctive clinicopathological characteristics and outcomes: a bicentric retrospective study"],"prefix":"10.1093","volume":"48","author":[{"given":"Ignasi","family":"Marti-Marti","sequence":"first","affiliation":[{"name":"Departments of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Bosch-Amate","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Morgado-Carrasco","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Albero-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Pathology, Hospital Cl\u00ednic de Barcelona, Universitat de Barcelona, Barcelona, Spain and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Santos-Briz","sequence":"additional","affiliation":[{"name":"Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Puebla-Tornero","sequence":"additional","affiliation":[{"name":"Pathology, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Revelles-Pe\u00f1as","sequence":"additional","affiliation":[{"name":"Pathology, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ca\u00f1ueto","sequence":"additional","affiliation":[{"name":"Pathology, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ll\u00facia","family":"Al\u00f2s","sequence":"additional","affiliation":[{"name":"Pathology, Hospital Cl\u00ednic de Barcelona, Universitat de Barcelona, Barcelona, Spain and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00ed","family":"Toll","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"2023100310345540600_llac086-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2018.09.062","article-title":"Human oncoviruses: mucocutaneous manifestations, pathogenesis, therapeutics, and prevention: papillomaviruses and Merkel cell polyomavirus","volume":"81","author":"Haley","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"2023100310345540600_llac086-B2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaad.2014.01.857","article-title":"Role of human papillomavirus in cutaneous squamous cell carcinoma: a meta-analysis","volume":"70","author":"Wang","year":"2014","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"2023100310345540600_llac086-B3","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/jdv.15547","article-title":"Distribution of high-risk \u03b1-genus human papillomavirus genotypes impacts cutaneous neoplasms","volume":"33","author":"Aoki","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023100310345540600_llac086-B4","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.jaad.2020.09.059","article-title":"Association of human papillomavirus and extra-genital Bowen disease (squamous cell carcinoma in situ): a systematic review","volume":"84","author":"Namgoong","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"2023100310345540600_llac086-B5","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.jaad.2019.03.070","article-title":"Nail squamous cell carcinoma: a hidden high-risk human papillomavirus reservoir for sexually transmitted infections","volume":"81","author":"Shimizu","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"2023100310345540600_llac086-B6","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/j.1365-2133.2009.09343.x","article-title":"Diversity of human papillomavirus types in periungual squamous cell carcinoma","volume":"161","author":"Kreuter","year":"2009","journal-title":"Br J Dermatol"},{"key":"2023100310345540600_llac086-B7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22083974","article-title":"Inflammatory molecules associated with ultraviolet radiation-mediated skin aging","volume":"22","author":"Ansary","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2023100310345540600_llac086-B8","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/1346-8138.12613","article-title":"Human papillomavirus infection in Bowen disease: negative p53 expression, not p16INK4a overexpression, is correlated with human papillomavirus-associated Bowen disease","volume":"41","author":"Murao","year":"2014","journal-title":"J Dermatol"},{"key":"2023100310345540600_llac086-B9","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/jdv.13654","article-title":"Bowen disease of the nail unit: a retrospective study of 12 cases and their association with human papillomaviruses","volume":"30","author":"Perruchoud","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"5 Suppl.","key":"2023100310345540600_llac086-B10","doi-asserted-by":"crossref","first-page":"S273","DOI":"10.1016\/j.jaad.2005.03.056","article-title":"Subungual Bowen\u2019s disease treated by topical aminolevulinic acid\u2013photodynamic therapy","volume":"53","author":"Usmani","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"2023100310345540600_llac086-B11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/ced.12149","article-title":"Multiple-digit periungual Bowen\u2019s disease: a novel treatment approach with radiotherapy","volume":"38","author":"Hunt","year":"2013","journal-title":"Clin Exp Dermatol"},{"key":"2023100310345540600_llac086-B12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1524-4725.2010.01860.x","article-title":"Cryosurgery as adjuvant to Mohs micrographic surgery in the management of subungual squamous cell carcinoma","volume":"37","author":"Ruiz Santiago","year":"2011","journal-title":"Dermatol Surg"},{"key":"2023100310345540600_llac086-B13","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.jaad.2010.02.057","article-title":"Ungual and periungual human papillomavirus-associated squamous cell carcinoma: a review","volume":"64","author":"Riddel","year":"2011","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"2023100310345540600_llac086-B14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1067\/mjd.2003.184","article-title":"Human papillomavirus-associated digital squamous cell carcinoma: literature review and report of 21 new cases","volume":"48","author":"Alam","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"2023100310345540600_llac086-B15","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/0190-9622(92)70144-5","article-title":"Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip: implications for treatment modality selection","volume":"26","author":"Rowe","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"2023100310345540600_llac086-B16","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1111\/j.1365-2133.2012.11129.x","article-title":"Mohs surgery for squamous cell carcinoma of the nail: report of 15 cases. Our experience and a long-term follow-up","volume":"167","author":"Dika","year":"2012","journal-title":"Br J Dermatol"},{"key":"2023100310345540600_llac086-B17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1524-4725.1992.tb02006.x","article-title":"Mohs micrographic surgery of the nail unit","volume":"18","author":"Goldminz","year":"1992","journal-title":"J Dermatol Surg Oncol"},{"key":"2023100310345540600_llac086-B18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1440-0960.2011.00813.x","article-title":"Mohs\u2019 micrographic surgery as treatment for squamous dysplasia of the nail unit","volume":"53","author":"Young","year":"2012","journal-title":"Australas J Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llac086\/48200417\/llac086.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/48\/3\/211\/51832797\/llac086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/48\/3\/211\/51832797\/llac086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:39:53Z","timestamp":1696329593000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/48\/3\/211\/6843676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,23]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,11,23]]},"published-print":{"date-parts":[[2023,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llac086","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3]]},"published":{"date-parts":[[2022,11,23]]}}}