{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T19:55:04Z","timestamp":1773258904087,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>As Sarcoptes scabiei is becoming less sensitive to permethrin, clinicians have started to prescribe oral ivermectin (OI) as a first-line treatment. Guidelines suggest OI 200\u2005\u00b5g kg\u20131 as two doses, 1 week apart. However, the black box of the ivermectin registered in Italy recommends a single dose. To compare these two regimens, we collected 71 cases of scabies and treated them according to this protocol [single-dose group (SDG)]. This population was compared to 68 patients who received two doses 1 week apart [double-dose group (DDG)]. Clearance of the disease was achieved in 98% of DDG patients. In the SDG, treatment was successful in only 58% of patients. This study confirms that the absence of a second intake of OI is one of the main predictors of treatment failure (P &amp;lt; 0.001), which may also increase the likelihood of emerging resistance in S. scabiei.<\/jats:p>","DOI":"10.1093\/ced\/llac092","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T01:57:58Z","timestamp":1673143078000},"page":"232-234","source":"Crossref","is-referenced-by-count":10,"title":["Oral ivermectin to treat scabies: a comparison of two different regimens"],"prefix":"10.1093","volume":"48","author":[{"given":"Riccardo","family":"Balestri","sequence":"first","affiliation":[{"name":"Division of Dermatology, STI Clinic, Trento Hospital , Trento , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Magnano","sequence":"additional","affiliation":[{"name":"Division of Dermatology, STI Clinic, Trento Hospital , Trento , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore Domenico","family":"Infusino","sequence":"additional","affiliation":[{"name":"Division of Dermatology, STI Clinic, Trento Hospital , Trento , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo R","family":"Girardelli","sequence":"additional","affiliation":[{"name":"Division of Dermatology, STI Clinic, Trento Hospital , Trento , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Ioris","sequence":"additional","affiliation":[{"name":"Division of Dermatology, STI Clinic, Trento Hospital , Trento , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Rech","sequence":"additional","affiliation":[{"name":"Division of Dermatology, STI Clinic, Trento Hospital , Trento , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"2023100310351031500_llac092-B1","doi-asserted-by":"crossref","first-page":"e889","DOI":"10.1111\/jdv.17538","article-title":"Scabies is becoming less sensitive to permethrin therapy","volume":"35","author":"Balestri","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023100310351031500_llac092-B2","doi-asserted-by":"crossref","first-page":"e15495","DOI":"10.1111\/dth.15495","article-title":"Use of oral ivermectin in permethrin-resistant scabies \u2013 a pilot study","volume":"35","author":"Balestri","year":"2022","journal-title":"Dermatol Ther"},{"key":"2023100310351031500_llac092-B3","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/jdv.14351","article-title":"European guideline for the management of scabies","volume":"31","author":"Salavastru","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023100310351031500_llac092-B4","author":"Codifa. 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