{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:26:27Z","timestamp":1786436787362,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hypereosinophilic syndrome (HES) is a heterogeneous group of diseases, characterized by persistent hypereosinophilia and end-organ damage. The FIP1L1\u2013PDGFRA (F\/P) fusion gene is found in 3\u201325% of patients with HES and is an oncogenic driver of myeloid neoplasms with clonal eosinophilia. Although cutaneous symptoms are the most common type of symptom in patients who have F\/P fusion gene-positive HES (F\/P HES), histological reports are limited. We herein present the case of a 78-year-old man with erythematous macules and severe pruritus on his trunk and extremities. Laboratory investigations revealed marked eosinophilia and elevated serum vitamin B12. A histological examination showed massive infiltration of eosinophils and mast cells around the vessels in the upper dermis. Fluorescence in situ hybridization revealed F\/P fusion genes in nuclei in the peripheral blood and the skin lesion. The patient was diagnosed with F\/P HES, and showed an excellent clinical and haematological response to imatinib.<\/jats:p>","DOI":"10.1093\/ced\/llac112","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T01:58:23Z","timestamp":1673143103000},"page":"364-367","source":"Crossref","is-referenced-by-count":5,"title":["Detection of <i>FIP1L1\u2013PDGFRA<\/i> fusion gene-positive cells in the skin lesion of a patient with hypereosinophilic syndrome"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-8997","authenticated-orcid":false,"given":"Shohei","family":"Kitayama","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama , Toyama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0536-1679","authenticated-orcid":false,"given":"Teruhiko","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama , Toyama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6077-8266","authenticated-orcid":false,"given":"Ayumi","family":"Yoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama , Toyama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama , Toyama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-3579","authenticated-orcid":false,"given":"Fumina","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama , Toyama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4808-5985","authenticated-orcid":false,"given":"Ryotaro","family":"Torai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama , Toyama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-3240","authenticated-orcid":false,"given":"Megumi","family":"Mizawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama , Toyama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3231-0279","authenticated-orcid":false,"given":"Tadamichi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama , Toyama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"key":"2023100315294555300_llac112-B1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jaci.2012.02.019","article-title":"Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes","volume":"130","author":"Valent","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"2023100315294555300_llac112-B2","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/ajh.25945","article-title":"Epidemiology, clinical picture and long-term outcomes of 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