{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:51:45Z","timestamp":1791082305503,"version":"4.1.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,19]]},"abstract":"<jats:p>Anifrolumab is a fully humanized monoclonal antibody targeting the type I interferon receptor and recently approved for the treatment of moderate-to-severe systemic lupus erythematosus. In addition to ameliorating systemic lupus activity, anifrolumab has emerged as a promising therapeutic option for patients with refractory cutaneous discoid lupus erythematosus (DLE), but its effect on mucosal DLE has yet to be investigated. In a prospective study of seven patients with severe mucosal DLE treated with anifrolumab, we observed substantial improvement in mucosal disease activity within 1\u2005month of anifrolumab initiation, suggesting that the impressive benefit of anifrolumab previously reported in cutaneous DLE extends to mucosal involvement.<\/jats:p>","DOI":"10.1093\/ced\/llad190","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T10:44:12Z","timestamp":1685184252000},"page":"1165-1167","source":"Crossref","is-referenced-by-count":7,"title":["Improvement in mucosal discoid lupus erythematosus with anifrolumab"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-1746","authenticated-orcid":false,"given":"Katharina","family":"Shaw","sequence":"first","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Sanchez-Melendez","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Barker","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Vermont Medical Center , Burlington, VT , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lonowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Nebraska Medical Center , Omaha, NE , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Shahriari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah J","family":"Porter","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Vermont Medical Center , Burlington, VT , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Morley","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Vermont Medical Center , Burlington, VT , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avery","family":"LaChance","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8446-7115","authenticated-orcid":false,"given":"Ruth Ann","family":"Vleugels","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,27]]},"reference":[{"key":"2023091916474891500_llad190-B1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1365-2133.1989.tb08215.x","article-title":"Mucosal involvement in systemic and chronic cutaneous lupus erythematosus","volume":"121","author":"Burge","year":"1989","journal-title":"Br J Dermatol"},{"key":"2023091916474891500_llad190-B2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-2559.2011.03934.x","article-title":"Malignant potential of oral and labial chronic discoid lupus erythematosus: a clinicopathological study of 87 cases","volume":"59","author":"Liu","year":"2011","journal-title":"Histopathology"},{"key":"2023091916474891500_llad190-B3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1001\/jamadermatol.2022.5242","article-title":"Treatment with anifrolumab for discoid lupus erythematosus","volume":"159","author":"Trentin","year":"2023","journal-title":"JAMA Dermatol"},{"key":"2023091916474891500_llad190-B4","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1111\/ced.15335","article-title":"Anifrolumab for treatment of refractory cutaneous lupus erythematosus","volume":"47","author":"Blum","year":"2022","journal-title":"Clin Exp Dermatol"},{"key":"2023091916474891500_llad190-B5","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1001\/jamadermatol.2023.0175","article-title":"Assessment of clinical response to anifrolumab in patients with refractory discoid lupus erythematosus","volume":"159","author":"Shaw","year":"2023","journal-title":"JAMA Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llad190\/50887363\/llad190.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/48\/10\/1165\/51685414\/llad190.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/48\/10\/1165\/51685414\/llad190.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T17:10:19Z","timestamp":1695143419000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/48\/10\/1165\/7181119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,27]]},"references-count":5,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5,27]]},"published-print":{"date-parts":[[2023,9,19]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llad190","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,10]]},"published":{"date-parts":[[2023,5,27]]}}}