{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:29:44Z","timestamp":1789867784871,"version":"4.0.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean government","award":["2017R1A5A2015369"],"award-info":[{"award-number":["2017R1A5A2015369"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Various comorbid diseases have been reported in patients with lichen planopilaris (LPP); however, data regarding the risks of incident diseases and mortality are lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the risks of incident diseases and mortality associated with LPP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective nationwide population-based study, using data from the National Health Insurance Service Database of Korea from 2002 to 2019. Patients aged \u2265 18\u2005years with three or more documented medical visits for LPP were included. The adjusted hazard ratios (aHRs) for incident disease outcomes and mortality were compared with 1 : 20 age-, sex-, insurance type- and income-level-matched controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 2026 patients with LPP and 40 520 controls were analysed. The risks of incident systemic lupus erythematosus [aHR 1.91, 95% confidence interval (CI) 1.21\u20133.03], psoriasis (aHR 3.42, 95% CI 2.83\u20134.14), rheumatoid arthritis (aHR 1.39, 95% CI 1.19\u20131.63), lichen planus (aHR, 10.07, 95% CI 7.17\u201314.15), atopic dermatitis (aHR 2.15, 95% CI 1.90\u20132.44), allergic rhinitis (aHR 1.29, 95% CI 1.13\u20131.49), thyroid diseases (hyperthyroidism: aHR 1.42, 95% CI 1.14\u20131.77, hypothyroidism aHR 1.19 95% CI 1.01\u20131.41, and thyroiditis:\u00a0aHR, 1.35, 95% CI 1.08\u20131.69), nonmelanoma skin cancer (aHR 2.33, 95% CI 1.00\u20135.44) and vitamin D deficiency (aHR 1.23, 95% CI 1.03\u20131.47) were higher in patients with LPP. Patients with LPP had a higher mortality rate than controls (aHR 1.30, 95% CI 1.04\u20131.61), although the risk was not significant after adjusting for comorbidities (aHR 1.08, 95% CI 0.87\u20131.34).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with LPP had a higher risk of various diseases following LPP diagnosis. Close follow-up is needed to optimize comprehensive patient care.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llad235","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T19:33:27Z","timestamp":1689104007000},"page":"1230-1237","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence and incidence of comorbid diseases and mortality risk associated with lichen planopilaris: a Korean nationwide population-based study"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2081-5261","authenticated-orcid":false,"given":"Sung Ha","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Dermatology, Yonsei University Wonju College of Medicine , Wonju, Republic of 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