{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:16:26Z","timestamp":1787008586828,"version":"build-2736575974"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lichen planus (LP)\u00a0is an inflammatory dermatosis with mucosal variants, including oral LP (OLP). OLP has a relapsing chronic course and may significantly affect a patient\u2019s quality of life. We analysed the efficacy of metronidazole as a treatment for OLP via a retrospective chart review of patients with a diagnosis of OLP seen at our institution over 10\u2005years. Thirty patients with OLP were treated with metronidazole 500\u2005mg twice daily. Most patients (n = 18; 60%) showed improvement with metronidazole, including 10 (33%) who experienced complete resolution of symptoms. Our results were limited by the retrospective nature of the review and the relatively small cohort size. Given the efficacy, mild side-effect profile and the less immunosuppressive nature of metronidazole vs. alternative systemic treatment options, metronidazole is a reasonable option to try in patients with symptomatic OLP who have failed topical treatment options.<\/jats:p>","DOI":"10.1093\/ced\/llad268","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T13:40:42Z","timestamp":1692193242000},"page":"1354-1357","source":"Crossref","is-referenced-by-count":5,"title":["A retrospective cohort study of the efficacy of metronidazole in oral lichen planus"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6849-1227","authenticated-orcid":false,"given":"Alison N","family":"Hollis","sequence":"first","affiliation":[{"name":"University of North Carolina at Chapel Hill Department of Dermatology, School of Medicine, , NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1257-0022","authenticated-orcid":false,"given":"Emma L","family":"Myers","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill Department of Dermatology, School of Medicine, , NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-6446","authenticated-orcid":false,"given":"Donna A","family":"Culton\u00a0","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill Department of Dermatology, School of Medicine, , NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"2023111605084124600_llad268-B1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00403-016-1667-2","article-title":"Oral lichen planus: a literature review and update","volume":"308","author":"Alrashdan","year":"2016","journal-title":"Arch Dermatol Res"},{"key":"2023111605084124600_llad268-B2","volume-title":"StatPearls","author":"Weir","year":"2021"},{"key":"2023111605084124600_llad268-B3","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0190-9622(89)80197-5","article-title":"Intestinal amebiasis, lichen planus, and treatment with metronidazole","volume":"20","author":"Wahba-Yahav","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"2023111605084124600_llad268-B4","first-page":"905","volume-title":"J Am Acad Dermatol","author":"Shelley","year":"1984"},{"key":"2023111605084124600_llad268-B5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0190-9622(95)90265-1","article-title":"Idiopathic lichen planus: treatment with metronidazole","volume":"33","author":"Wahba-Yahav","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"2023111605084124600_llad268-B6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1468-3083.2004.00989.x","article-title":"Two case reports of cutaneous adverse reactions following hepatitis B vaccine: lichen planus and granuloma annulare","volume":"18","author":"Criado","year":"2004","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023111605084124600_llad268-B7","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/cup.13645","article-title":"Lichen planus related to transforming growth factor beta inhibitor in a patient with metastatic chondrosarcoma: a case report","volume":"47","author":"Farah","year":"2020","journal-title":"J Cutan Pathol"},{"key":"2023111605084124600_llad268-B8","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1159\/000518313","article-title":"Skin deep: a fascinating case report of immunotherapy-triggered, treatment-refractory autoimmune lichen planus and keratoacanthoma","volume":"14","author":"Preti","year":"2021","journal-title":"Case Rep Oncol"},{"key":"2023111605084124600_llad268-B9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1067\/mjd.2000.104683","article-title":"Oral metronidazole treatment of lichen planus","volume":"43","author":"B\u00fcy\u00fck","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"2023111605084124600_llad268-B10","article-title":"Efficacy of oral metronidazole in treatment of cutaneous and mucosal lichen planus","volume":"9","author":"Rasi","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"2023111605084124600_llad268-B11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.otc.2010.09.004","article-title":"Oral lichen planus","volume":"44","author":"Parashar","year":"2011","journal-title":"Otolaryngol Clin North Am"},{"key":"2023111605084124600_llad268-B12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ijantimicag.2017.08.033","article-title":"Clinical relevance of metronidazole and peripheral neuropathy: a systematic review of the literature","volume":"51","author":"Goolsby","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"2023111605084124600_llad268-B13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tripleo.2004.06.076","article-title":"Current controversies in oral lichen planus: report of an international consensus meeting","volume":"100","author":"Lodi","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"2023111605084124600_llad268-B14","first-page":"141247","article-title":"Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis","author":"Lin","year":"2021","journal-title":"Mucosal Immunol"},{"key":"2023111605084124600_llad268-B15","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/ced.14987","article-title":"The human microbiome in immunobullous disorders and lichen planus","volume":"47","author":"Karimova","year":"2022","journal-title":"Clin Exp Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llad268\/51859387\/llad268.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/48\/12\/1354\/53456395\/llad268.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/48\/12\/1354\/53456395\/llad268.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:09:34Z","timestamp":1700093374000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/48\/12\/1354\/7243249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,16]]},"references-count":15,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,8,16]]},"published-print":{"date-parts":[[2023,11,16]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llad268","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2023,8,16]]}}}