{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:57:37Z","timestamp":1760029057829,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012331","name":"LEO Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Odense University Hospital Free Research Fund"},{"name":"Robert Wehnerts and Kirsten Wehnerts Foundation"},{"name":"Psoriasis Research Foundation"},{"name":"Jeweller A. L. Rasmussens Memorial Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A randomized controlled trial (RCT) of topical treatment combined with regular patient support provided by dermatological nurses in structured consultations of 20-min duration every fourth week improved psoriasis severity, quality of life and treatment adherence compared with topical treatment combined with standard patient support, which is seeing a dermatologist every third month.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To examine the economic impact of the patient support from a healthcare-sector perspective in the RCT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Costs for primary care, secondary healthcare services and costs of prescription medication were compared for the intervention and nonintervention groups over 48 weeks. Health benefits were expressed in terms of quality-adjusted life-years (QALYs) measured by the EuroQoL five-dimension three-level questionnaire. Regression analyses were used to estimate incremental cost and QALYs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The incremental cost was estimated at \u00a3462, with an average increase of 0.08 QALYs per patients for participants receiving the intervention compared with those receiving standard care. The incremental cost-effectiveness ratio for patients was \u00a35999\/QALY. The intervention had an almost 100% probability of being cost-effective at a willingness-to-pay threshold of \u00a330 000 per QALY.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Addressing adherence issues is critical to improving outcomes for patients with psoriasis who use topical treatment. The personal support intervention was effective with an acceptable increase in costs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llad272","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T17:40:46Z","timestamp":1692207646000},"page":"1247-1254","source":"Crossref","is-referenced-by-count":1,"title":["An effective patient-supporting intervention for topical treatment of psoriasis is also cost-effective"],"prefix":"10.1093","volume":"48","author":[{"given":"Mathias Tiedemann","family":"Svendsen","sequence":"first","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark"},{"name":"Open Patient data Exploratory Network (OPEN), Odense University Hospital , Odense , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus 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