{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:25:41Z","timestamp":1756995941575,"version":"3.37.3"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000296","name":"British Skin Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000296","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011319","name":"Skin Treatment and Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The epidemiology and potential pathogenic roles of human papillomavirus (HPV) and Merkel cell polyomavirus (MCV) in keratinocyte cancers (KCs) arising in people living with HIV (PLWH) compared with HIV-negative individuals are poorly understood. These issues were investigated by a case\u2013control study in which the presence of MCV and HPV DNA was identified by polymerase chain reaction in microdissected formalin-fixed paraffin-embedded tissue from PLWH and HIV-negative individuals. The samples comprised 190 cutaneous and genital KCs\/precancers (actinic keratoses, n = 43; cutaneous squamous cell carcinoma (cSCC) in situ, n = 24; basal cell carcinoma, n = 78; cSCC, n = 34; penile carcinoma in situ, n = 9; penile SCC, n = 2 from 104 individuals (PLWH, n = 51; HIV-negative, n = 53). Almost one-quarter of samples were positive for MCV: this was not significantly associated with either HIV status (P = 0.06) nor lesion type. Overall, 36% (16\/44) of MCV-positive lesions were coinfected with HPV; this was also not associated with HIV status. These findings indicate that if these viruses do contribute to the pathogenesis of KCs, it is likely to be independent of HIV status.<\/jats:p>","DOI":"10.1093\/ced\/llad336","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T20:04:33Z","timestamp":1696449873000},"page":"263-266","source":"Crossref","is-referenced-by-count":1,"title":["Is the presence of Merkel cell polyomavirus and human\u00a0papillomavirus DNA in keratinocyte cancers and\u00a0precancers associated with HIV status? A case\u2013control study"],"prefix":"10.1093","volume":"49","author":[{"given":"Sacha I","family":"Goolamali","sequence":"first","affiliation":[{"name":"Dermatology Department, Chelsea and Westminster Hospital , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tang N","family":"Shim","sequence":"additional","affiliation":[{"name":"Dermatology Department, Chelsea and Westminster Hospital , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Purdie","sequence":"additional","affiliation":[{"name":"Blizard Institute, Queen Mary University of London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikol","family":"Mladkova","sequence":"additional","affiliation":[{"name":"Blizard Institute, Queen Mary University of London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Francis","sequence":"additional","affiliation":[{"name":"Histopathology Department, Imperial College , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine\u00a0A","family":"Harwood","sequence":"additional","affiliation":[{"name":"Blizard Institute, Queen Mary University of London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B","family":"Bunker","sequence":"additional","affiliation":[{"name":"Dermatology Department, Chelsea and Westminster Hospital , London , UK"},{"name":"Dermatology Department, University College Hospital , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"2024021702381235900_llad336-B1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.det.2018.07.009","article-title":"Skin cancer and Immunosuppression","volume":"37","author":"Collins","year":"2019","journal-title":"Dermatol 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implications","volume":"121","author":"Coursaget","year":"2013","journal-title":"APMIS"},{"key":"2024021702381235900_llad336-B5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/ced.13069","article-title":"Molecular prevalence of Merkel cell polyomavirus in nonmelanoma skin cancer in a Brazilian population","volume":"42","author":"Bellott","year":"2017","journal-title":"Clin Exp Dermatol"},{"issue":"Suppl. 2","key":"2024021702381235900_llad336-B6","first-page":"217","article-title":"Merkel cell polyomavirus in the pathogenesis of non-melanoma skin cancer","volume":"30","author":"Hausen A","year":"2009","journal-title":"Pathologe"},{"key":"2024021702381235900_llad336-B7","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1128\/JCM.02122-09","article-title":"Evaluation of a novel broad-spectrum PCR-multiplex genotyping assay for identification of cutaneous wart-associated human papillomavirus types","volume":"48","author":"De 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