{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:16:24Z","timestamp":1787008584769,"version":"build-2736575974"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:00:00Z","timestamp":1696636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,25]]},"abstract":"<jats:p>Here we report a case of upadacitinib in the treatment of generalized pustular psoriasis complicated with psoriatic arthritis. We chose upadacitinib after the use of acitretin did not work well, and achieved a tremendous therapeutic effect. Upadacitinib not only relieved the joint symptoms and fever, but also played a good role in the regression of pustules. At present, there are no successful cases of Janus kinase inhibitor use in the treatment of generalized pustular psoriasis.<\/jats:p>","DOI":"10.1093\/ced\/llad341","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T15:23:24Z","timestamp":1696692204000},"page":"170-172","source":"Crossref","is-referenced-by-count":10,"title":["A case of refractory generalized pustular psoriasis treated with upadacitinib"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-6364","authenticated-orcid":false,"given":"Xuesong","family":"Wang","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases, Shandong First Medical University , Jinan, Shandong , China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Yan","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases, Shandong First Medical University , Jinan, Shandong , China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases, Shandong First Medical University , Jinan, Shandong , China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases, Shandong First Medical University , Jinan, Shandong , China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,7]]},"reference":[{"key":"2024012519205810800_llad341-B1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054901","article-title":"Psoriatic arthritis: pathogenesis and targeted therapies","volume":"24","author":"Azuaga","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2024012519205810800_llad341-B2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s40265-017-0701-9","article-title":"JAK-STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects","volume":"77","author":"Banerjee","year":"2017","journal-title":"Drugs"},{"key":"2024012519205810800_llad341-B3","doi-asserted-by":"crossref","first-page":"102750","DOI":"10.1016\/j.autrev.2021.102750","article-title":"Working and safety profiles of JAK\/STAT signaling inhibitors. Are these small molecules also smart?","volume":"20","author":"Favoino","year":"2021","journal-title":"Autoimmun Rev"},{"key":"2024012519205810800_llad341-B4","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s40265-019-01211-z","article-title":"Upadacitinib: first approval","volume":"79","author":"Duggan","year":"2019","journal-title":"Drugs"},{"key":"2024012519205810800_llad341-B5","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9121746","article-title":"Pustular psoriasis: from pathophysiology to treatment","volume":"9","author":"Genovese","year":"2021","journal-title":"Biomedicines"},{"key":"2024012519205810800_llad341-B6","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1136\/annrheumdis-2021-221761","article-title":"Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis","volume":"81","author":"Floudas","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"2024012519205810800_llad341-B7","first-page":"251","article-title":"Off-label use of tocilizumab in psoriatic arthritis: case series and review of the literature","volume":"41","author":"Madureira","year":"2016","journal-title":"Acta Rheumatol Port"},{"key":"2024012519205810800_llad341-B8","article-title":"Tocilizumab for giant cell arteritis","volume":"8","author":"Antonio","year":"2021","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llad341\/53977629\/llad341.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/49\/2\/170\/56420931\/llad341.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/49\/2\/170\/56420931\/llad341.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T14:21:25Z","timestamp":1706192485000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/49\/2\/170\/7299428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,7]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,10,7]]},"published-print":{"date-parts":[[2024,1,25]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llad341","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2023,10,7]]}}}