{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:41:03Z","timestamp":1768405263131,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009128","name":"Research for Patient Benefit programme","doi-asserted-by":"publisher","award":["PB-PG-0418-20021"],"award-info":[{"award-number":["PB-PG-0418-20021"]}],"id":[{"id":"10.13039\/501100009128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003921","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Venous leg ulcers (VLUs) heal slowly, are painful for patients and are costly for healthcare systems; they also affect patients\u2019 quality of life. Previous work suggests that supervised exercise training used in combination with compression therapy may offer clinical benefits. However, a large population of people with VLUs are unable to access such an intervention due to frailty and age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To assess the feasibility of \u2018FISCU Home\u2019 (a co-designed, 12-week home-based self-managed lifestyle programme based on exercise and behaviour support) as an adjunct therapy to compression in people with VLUs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Forty people with VLUs, receiving treatment at home, were recruited from community nursing and tissue viability teams, and via a newspaper advertisement. Participants were randomized 1 : 1 either to exercise with behaviour support (three times per week) plus compression therapy or compression only. The feasibility of the programme was assessed using progression criteria that included exercise attendance rate, loss to follow-up, patient preference(s) and adverse events (AEs). Baseline assessments were repeated at 12 weeks and 6\u2005months. Secondary outcomes (i.e. ulcer recurrence, healing rate and healing time) were also documented at these intervals. Intervention and healthcare utilization costs were calculated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study recruitment rate was 65%, while 75% of the exercise group participants attended all scheduled exercise sessions. All participants completed compression therapy. No serious AEs or exercise-related AEs were reported. Median (interquartile range) ulcer healing time was shorter in the exercise group [29 (7\u2013108) vs. 42 (6\u2013116) weeks].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The feasibility and acceptability of both a home- and exercise-based lifestyle intervention in conjunction with compression therapy and the study procedures are supported.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llad342","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:56:03Z","timestamp":1697039763000},"page":"135-142","source":"Crossref","is-referenced-by-count":4,"title":["Testing the feasibility of a co-designed intervention, comprising self-managed, home-based, exercise training with embedded behavioural support and compression therapy\u00a0for people with venous leg ulcers receiving treatment at home (FISCU-II)"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8864-4403","authenticated-orcid":false,"given":"Markos","family":"Klonizakis","sequence":"first","affiliation":[{"name":"Lifestyle, Exercise and Nutrition Improvement (LENI) Research Group, Department of Nursing and Midwifery, Sheffield Hallam University , Sheffield , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Gumber","sequence":"additional","affiliation":[{"name":"Lifestyle, Exercise and Nutrition Improvement (LENI) Research Group, Department of Nursing and Midwifery, Sheffield Hallam University , Sheffield , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"McIntosh","sequence":"additional","affiliation":[{"name":"Lifestyle, Exercise and Nutrition Improvement (LENI) Research Group, Department of Nursing and Midwifery, Sheffield Hallam University , Sheffield , UK"},{"name":"Research and Innovation, Sheffield Health and Social Care NHS Foundation Trust , Sheffield , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Levesley","sequence":"additional","affiliation":[{"name":"Integrated Care Team, Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Horspool","sequence":"additional","affiliation":[{"name":"Research and Innovation, Sheffield Health and Social Care NHS Foundation Trust , Sheffield , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pip","family":"Logan","sequence":"additional","affiliation":[{"name":"Centre for Rehabilitation and Ageing Research, University of Nottingham , Nottingham , UK"},{"name":"Nottingham CityCare Partnership , Nottingham , 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