{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:07Z","timestamp":1780444807110,"version":"3.54.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mastocytosis, lichen planus pigmentosus (LPP), fixed drug eruption (FDE) and caf\u00e9-au-lait macules (CALM) have a similar appearance, often lead to misdiagnosis and missed diagnoses. At the outpatient clinic at Tianjin Children\u2019s Hospital in 21 patients with mastocytosis, 18 with LPP, 11 with FDE and 12 with CALM we evaluated the characteristics and distinguishing features of their dermatoses using reflectance confocal microscopy (RCM). In mastocytosis, the dermal papillary rings generally had a significantly increased bright refractive index and the superficial dermis was filled with moderate refractive flocculent material. In LPP, the dermal papillary rings were absent and numerous different-sized cellular structures were densely distributed in the superficial dermis. In FDE, the dermal papillary rings were intact with a significantly increased bright refractive index. In CALM, normal dermal papillary rings were detected with a uniformly slightly increased refractive index and no obvious abnormality in the superficial dermis. RCM allows for real-time visualization of the major key diagnostic and distinguishing features of four greyish-brown dermatoses in children.<\/jats:p>","DOI":"10.1093\/ced\/llad354","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T11:48:46Z","timestamp":1697543326000},"page":"259-262","source":"Crossref","is-referenced-by-count":2,"title":["Reflectance confocal microscopy as a complementary diagnostic tool for greyish-brown dermatoses in children"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5163-5116","authenticated-orcid":false,"given":"Lixin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Tianjin Children\u2019s Hospital , Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5265-5058","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tianjin Children\u2019s Hospital , Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xibo","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tianjin Children\u2019s Hospital , Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1200-8566","authenticated-orcid":false,"given":"Qinfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tianjin Children\u2019s Hospital , Tianjin , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"2024021702391853200_llad354-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2020.05.153","article-title":"Reflectance confocal microscopy: principles, basic terminology, clinical indications, limitations, and practical considerations","volume":"84","author":"Shahriari","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"2024021702391853200_llad354-B2","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.jaad.2020.07.130","article-title":"In vivo imaging characterization of basal cell carcinoma and cutaneous response to high-dose ionizing radiation therapy: a prospective study of reflectance confocal microscopy, dermoscopy, and ultrasonography","volume":"84","author":"Navarrete-Dechent","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"2024021702391853200_llad354-B3","doi-asserted-by":"crossref","first-page":"e13234","DOI":"10.1111\/srt.13234","article-title":"evaluation of vulvar lichen\u00a0sclerosus with reflectance confocal microscopy and \u00adtherapeutic monitoring in children","volume":"29","author":"Chen","year":"2023","journal-title":"Skin Res Technol"},{"key":"2024021702391853200_llad354-B4","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jaad.2020.03.091","article-title":"Reflectance confocal microscopy as a diagnostic tool for mastocytoma in children","volume":"83","author":"An","year":"2020","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"2024021702391853200_llad354-B5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/srt.12779","article-title":"Concordance of reflectance confocal microscopy with histopathology in the diagnosis of mastocytosis: a prospective study","volume":"26","author":"Zhang","year":"2020","journal-title":"Skin Res Technol"},{"key":"2024021702391853200_llad354-B6","doi-asserted-by":"crossref","first-page":"e160","DOI":"10.1111\/ajd.13988","article-title":"Reflectance confocal microscopy-assisted diagnosis of lichen planus pigmentosus distributed along multiple unilateral Blaschko's lines in a child: a case report","volume":"64","author":"Wang","year":"2023","journal-title":"Australas J Dermatol"},{"key":"2024021702391853200_llad354-B7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/0961203320958141","article-title":"The combined role of clinical, reflectance confocal microscopy and dermoscopy applied to chronic discoid cutaneous lupus and subacutus lupus erythematosus: a case series and literature review","volume":"30","author":"Mazzilli","year":"2021","journal-title":"Lupus"},{"key":"2024021702391853200_llad354-B8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/srt.12616","article-title":"Reflectance confocal microscopy for the noninvasive diagnosis of cutaneous juvenile xanthogranuloma","volume":"25","author":"Pimenta","year":"2019","journal-title":"Skin Res Technol"},{"key":"2024021702391853200_llad354-B9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/srt.12460","article-title":"Handheld reflectance confocal microscopy, dermatoscopy and histopathological correlation of common inflammatory balanitis","volume":"24","author":"Lacarrubba","year":"2018","journal-title":"Skin Res Technol"},{"key":"2024021702391853200_llad354-B10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/srt.13170","article-title":"In vivo evaluation of facial papule dermatoses with reflectance confocal microscopy in children","volume":"28","author":"Chen","year":"2022","journal-title":"Skin Res Technol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llad354\/54705713\/llad354.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/49\/3\/259\/56679088\/llad354.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/49\/3\/259\/56679088\/llad354.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T02:39:30Z","timestamp":1708137570000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/49\/3\/259\/7319412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,10,17]]},"published-print":{"date-parts":[[2024,2,14]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llad354","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2023,10,17]]}}}