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The CD1a subtype is highly and continuously expressed within the skin, most notably on Langerhans cells, and has been demonstrated to present self and foreign lipids to T cells, highlighting its cutaneous sentinel role. Alteration of CD1a-dependent T-cell responses has recently been discovered to contribute to the pathogenesis of several inflammatory skin diseases. In this review, we overview the structure and role of CD1a and outline the current evidence implicating CD1a in the development of psoriasis, atopic dermatitis and allergic contact dermatitis.<\/jats:p>","DOI":"10.1093\/ced\/llad460","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T14:14:31Z","timestamp":1704291271000},"page":"450-458","source":"Crossref","is-referenced-by-count":11,"title":["CD1a and skin T cells: a pathway for therapeutic intervention"],"prefix":"10.1093","volume":"49","author":[{"given":"John H","family":"Ye","sequence":"first","affiliation":[{"name":"MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford , Oxford , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford , Oxford , 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